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Cited by 773

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

Genetic Characterization of Zika Virus Strains: Geographic Expansion of the Asian Lineage

Open access
Haddow, Andrew D., Schuh, Amy J., Yasuda, Chadwick Y., Kasper, Matthew R., Heang, Vireak, Huy, Rekol, Guzman, Hilda, Tesh, Robert B., Weaver, Scott C.·2012·PLoS Neglected Tropical Diseases
DOI 10.1371/journal.pntd.0001477
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Abstract

BACKGROUND: Zika virus (ZIKV) is a mosquito-borne flavivirus distributed throughout much of Africa and Asia. Infection with the virus may cause acute febrile illness that clinically resembles dengue fever. A recent study indicated the existence of three geographically distinct viral lineages; however this analysis utilized only a single viral gene. Although ZIKV has been known to circulate in both Africa and Asia since at least the 1950s, little is known about the genetic relationships between geographically distinct virus strains. Moreover, the geographic origin of the strains responsible for the epidemic that occurred on Yap Island, Federated States of Micronesia in 2007, and a 2010 pediatric case in Cambodia, has not been determined. METHODOLOGY/PRINCIPAL FINDINGS: To elucidate the genetic relationships of geographically distinct ZIKV strains and the origin of the strains responsible for the 2007 outbreak on Yap Island and a 2010 Cambodian pediatric case of ZIKV infection, the nucleotide sequences of the open reading frame of five isolates from Cambodia, Malaysia, Nigeria, Uganda, and Senegal collected between 1947 and 2010 were determined. Phylogenetic analyses of these and previously published ZIKV sequences revealed the existence of two main virus lineages (African and Asian) and that the strain responsible for the Yap epidemic and the Cambodian case most likely originated in Southeast Asia. Examination of the nucleotide and amino acid sequence alignments revealed the loss of a potential glycosylation site in some of the virus strains, which may correlate with the passage history of the virus. CONCLUSIONS/SIGNIFICANCE: The basal position of the ZIKV strain isolated in Malaysia in 1966 suggests that the recent outbreak in Micronesia was initiated by a strain from Southeast Asia. Because ZIKV infection in humans produces an illness clinically similar to dengue fever and many other tropical infectious diseases, it is likely greatly misdiagnosed and underreported.

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Metadata

Authors
Haddow, A. D., Schuh, A. J., Yasuda, C. Y., Kasper, M. R., Heang, V., Huy, R., Guzman, H., Tesh, R. B., & Weaver, S. C.
Venue
PLoS Neglected Tropical Diseases
Publisher
Public Library of Science (PLoS)
Published
2012-02-28
Volume
6
Issue
2
Pages
e1477
ISSN
  • 1935-2727 (ISSN-L)
  • 1935-2735
DOI
10.1371/journal.pntd.0001477
OpenAlex
W2073049582
Cited by
773
References
47
FWCI
12.15
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Genetic Characterization of Zika Virus Strains: Geographic Expansion of the Asian Lineage. https://app.cochat.ai/papers/10.1371/journal.pntd.0001477
The paper
Haddow, A. D., Schuh, A. J., Yasuda, C. Y., Kasper, M. R., Heang, V., Huy, R., Guzman, H., Tesh, R. B., & Weaver, S. C. (2012). Genetic Characterization of Zika Virus Strains: Geographic Expansion of the Asian Lineage. PLoS Neglected Tropical Diseases. https://doi.org/10.1371/journal.pntd.0001477

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.