Cited by 159Malaria Research and ControlPhytochemical compounds biological activitiesSesquiterpenes and Asteraceae Studies

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Potentiation of the antimalarial activity of qinghaosu by methoxylated flavones

Elford, Barry C., Roberts, Margaret F., Phillipson, J.David, Wilson, Robert J.M.·1987·Transactions of the Royal Society of Tropical Medicine and Hygiene

DOI 10.1016/0035-9203(87)90161-1

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Abstract

Interaction between the flavones casticin and artemetin and the antimalarial activity of chloroquine and qinghaosu (QHS) was examined using an in vitro growth assay based on [3H]hypoxanthine incorporation in synchronized cultures of a cloned line of Plasmodium falciparum. Casticin, and to a lesser extent artemetin, selectively enhanced the inhibition of growth by QHS, but had little effect on the activity of chloroquine. The findings suggest that flavones indigenous to Artemisia annua, from which QHS is isolated, might significantly alter the clinical potential of this novel antimalarial drug in the treatment of chloroquine-resistant malaria.

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Authors: Elford, B. C., Roberts, M. F., Phillipson, J. D., & Wilson, R. J. M.
Affiliations: University of London (GB)
ORCID: Wilson, Robert J.M.
Venue: Transactions of the Royal Society of Tropical Medicine and Hygiene
Publisher: Oxford University Press (OUP)
Published: 1987-01
Volume: 81
Issue: 3
Pages: 434-436
ISSN: 0035-9203 (ISSN-L)
DOI: 10.1016/0035-9203(87)90161-1
OpenAlex: W2121036679
Cited by: 159
References: 18
Citations by year: 2026: 1 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 3 · 2019: 8 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 7 · 2014: 5 · 2013: 10 · 2012: 10
FWCI: 4.37
Type: journal article
Language: en
Open access: closed
Locations: Transactions of the Royal Society of Tropical Medicine and Hygiene (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Phytochemical compounds biological activities
Physical Sciences › Chemistry › Organic Chemistry › Sesquiterpenes and Asteraceae Studies
Keywords: artemisinin, methoxylated flavones, casticin, artemetin, chloroquine resistance, Plasmodium falciparum, Artemisia annua, drug interactions, antimalarial activity
MeSH terms: Animals, Antimalarials, Clone Cells, Dose-Response Relationship, Drug, Drug Synergism, Flavonoids, Plasmodium falciparum, Sesquiterpenes, Artemisinins

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Potentiation of the antimalarial activity of qinghaosu by methoxylated flavones

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