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Cited by 73

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Functional dissociation of transforming genes of human papillomavirus type 16

Yutsudo, Masuo, Okamoto, Yuji, Hakura, Akira·1988·Virology
DOI 10.1016/0042-6822(88)90532-6
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Abstract

Human papillomavirus (HPV) type 16 is thought to be responsible for development of cervical carcinomas, but the mechanism of its carcinogenic action is unknown. To determine which viral genes are involved in cellular transformation, we constructed recombinant murine retrovirus DNAs containing various subgenomic fragments of the HPV 16 early region and examined their transforming activities. The results show that the E6 and E7 ORFs are the transforming genes of HPV 16; the former governs the tumorigenicity in nude mice and the latter influences cell growth properties such as saturation density and colony formation in soft agar. There may also be a tumor-suppressing gene in the E1-E2 ORF region, because the tumorigenic activity of recombinant DNA containing the E1 ORF and the 5' portion of the E2 ORF in addition to the E6 and E7 ORFs was much lower than that of recombinant DNA containing only the E6 and E7 ORFs.

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Research works printed but not linked: 30

  1. Orth, 1980, Cold Spring Harbor Conf. Cell Prolif., 7, 259
  2. Yutsudo, 1985, Virology, 144, 295, 10.1016/0042-6822(85)90328-9 · DOI
  3. Du¨rst, 1983, 80, 3812
  4. Boshart, 1984, EMBO J., 3, 1151, 10.1002/j.1460-2075.1984.tb01944.x · DOI
  5. Lorincz, 1986, J. Virol., 58, 225, 10.1128/jvi.58.1.225-229.1986 · DOI
  6. Beaudenon, 1986, Nature (London), 321, 246, 10.1038/321246a0 · DOI
  7. Lorincz, 1987, Virology, 159, 187, 10.1016/0042-6822(87)90366-7 · DOI
  8. Schneider, 1985, Int. J. Cancer, 35, 443, 10.1002/ijc.2910350405 · DOI
  9. Fukushima, 1985, Cancer Res., 45, 3252
  10. Yee, 1985, Amer. J. Pathol., 119, 361
  11. Smotkin, 1986, 83, 4680
  12. Androphy, 1987, EMBO J., 6, 989, 10.1002/j.1460-2075.1987.tb04849.x · DOI
  13. Yasumoto, 1986, J. Virol., 57, 572, 10.1128/jvi.57.2.572-577.1986 · DOI · Paper page
  14. Kanda, 1987, Japan J. Cancer Res., 78, 103
  15. Pirici, 1987, J. Virol., 61, 1061, 10.1128/jvi.61.4.1061-1066.1987 · DOI
  16. Tsunokawa, 1986, 83, 2200
  17. Cepko, 1984, Cell, 37, 1053, 10.1016/0092-8674(84)90440-9 · DOI
  18. Mann, 1983, Cell, 33, 153, 10.1016/0092-8674(83)90344-6 · DOI
  19. Matlashewski, 1987, Cancer Cells, 5, 195
  20. Schwarz, 1987, Cancer Cells, 5, 47
  21. Lusky, 1986, J. Virol., 60, 729, 10.1128/jvi.60.2.729-742.1986 · DOI
  22. Seedorf, 1985, Virology, 145, 181, 10.1016/0042-6822(85)90214-4 · DOI
  23. Matsukura, 1986, J. Virol., 58, 979, 10.1128/jvi.58.3.979-982.1986 · DOI
  24. Baker, 1987, J. Virol., 61, 962, 10.1128/jvi.61.4.962-971.1987 · DOI
  25. Phelps, 1987, J. Virol., 61, 1630, 10.1128/jvi.61.5.1630-1638.1987 · DOI
  26. Cripe, 1987, EMBO J., 6, 3745, 10.1002/j.1460-2075.1987.tb02709.x · DOI
  27. Yang, 1985, Nature (London), 318, 575, 10.1038/318575a0 · DOI
  28. Schiller, 1984, 81, 7880
  29. Lehn, 1985, 82, 5540
  30. Schwarz, 1985, Nature (London), 314, 111, 10.1038/314111a0 · DOI

Cited by

Metadata

Authors
Yutsudo, M., Okamoto, Y., & Hakura, A.
Venue
Virology
Publisher
Elsevier BV
Published
1988-10
Volume
166
Issue
2
Pages
594-597
ISSN
0042-6822
DOI
10.1016/0042-6822(88)90532-6
Cited by
73
References
0
Language
en
Licence
Funders
  • Ministry of Education, Culture, Sports, Science and Technology
  • Ministry of Health, Labour and Welfare

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