The DOI matches its Crossref record.
Human papillomavirus type 16 DNA-induced malignant transformation of NIH 3T3 cells
Abstract
A biological function for human papillomavirus 16 (HPV 16) DNA was demonstrated by transformation of NIH 3T3 cells. HPV 16 DNA has been found frequently in genital cancer and has been classified as a papillomavirus on the basis of DNA homology. A recombinant HPV 16 DNA (pSHPV16d), which contains a head-to-tail dimer of the full-length HPV 16 genome, induced morphologic transformation; the transformed cells were tumorigenic in nude mice. Expression of transforming activity was unique because of the long latency period (more than 4 weeks) required for induction of morphologic transformation and because the transfected DNA existed primarily in a multimeric form with some rearrangements. Furthermore, virus-specific RNAs were expressed in the transformants. The transformation of NIH 3T3 cells provides a model for analyzing the functions of HPV 16, which is associated with cervical carcinomas.
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“The cellular transforming activity of high-risk HPV genomes was established in the mid-1980s in rodent cell line transformation assays [54,78]”
From The Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis (2021) · cites this paper as [78]
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Cited by
The human papilloma virus-16 E7-oncoprotein is able to bind to the retinoblastoma gene product
Dyson, N., Howley, P. M., Münger, K., & Harlow, E. (1989) · Science · doi:10.1126/science.2537532 · Cited by 3,017
Papillomaviruses in the causation of human cancers - a brief historical account
zur Hausen, H. (2009) · Virology · doi:10.1016/j.virol.2008.11.046 · Cited by 1,532
Basukala, O., & Banks, L. (2021) · Viruses · doi:10.3390/v13101892 · Cited by 137
Metadata
- Authors
- Yasumoto, S., Burkhardt, A. L., Doniger, J., & DiPaolo, J. A.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1986-02
- Volume
- 57
- Issue
- 2
- Pages
- 572-577
- ISSN
- 0022-538X
- 1098-5514
- Cited by
- 183
- References
- 0
- Language
- en
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- CoChat. (2026). Citation check: Human papillomavirus type 16 DNA-induced malignant transformation of NIH 3T3 cells. https://app.cochat.ai/papers/10.1128/jvi.57.2.572-577.1986
- The paper
- Yasumoto, S., Burkhardt, A. L., Doniger, J., & DiPaolo, J. A. (1986). Human papillomavirus type 16 DNA-induced malignant transformation of NIH 3T3 cells. Journal of Virology. https://doi.org/10.1128/jvi.57.2.572-577.1986
