Immunological Senescence in Mice and Its Reversal by Coenzyme Q10

Experimental Immunochemistry

Witebsky, E. (1962) · JAMA · doi:10.1001/jama.1962.03050070106026 · Cited by 1,330 · see citing works

Thymus-Marrow Cell Combinations. Synergism in Antibody Production.

Claman, H. N., Chaperon, E. A., & Triplett, R. F. (1966) · Experimental Biology and Medicine · doi:10.3181/00379727-122-31353 · Cited by 612 · see citing works

Thymus and Antigen‐Reactive Cells

MILLER, J. F. A. P., & Mitchell, G. F. (1969) · Immunological Reviews · doi:10.1111/j.1600-065x.1969.tb00135.x · Cited by 338 · see citing works

Thymic Involution: Effect on T Cell Differentiation

Hirokawa, K., & Makinodan, T. (1975) · The Journal of Immunology · doi:10.4049/jimmunol.114.6.1659 · Cited by 183 · see citing works

Biomedical and Clinical Aspects of Coenzyme Q

Goodwin, T. W. (1977) · FEBS Letters · doi:10.1016/0014-5793(77)80678-9 · Cited by 132 · see citing works

AN IMMUNOLOGICAL APPROACH TO AGEING

Burnet, F. M. (1970) · The Lancet · doi:10.1016/s0140-6736(70)92886-2 · Cited by 123 · see citing works

Lymphocyte Interactions in Antibody Responses

Miller, J. F. A. P. (1972) · International review of cytology · doi:10.1016/s0074-7696(08)61449-7 · Cited by 103 · see citing works

Enzyme Changes in Ageing Mammals

Wilson, P. D. (2009) · Gerontologia · doi:10.1159/000211964 · Cited by 85 · see citing works

The Effect of Age on Mitochondrial Ultrastructure

Wilson, P. D., & Franks, L. M. (2009) · Gerontologia · doi:10.1159/000212035 · Cited by 78 · see citing works

Prolongation of the Life-Span in Mice Adapted to Large Amounts of L-Dopa

Cotzias, G. C., Miller, S. T., Nicholson, A. R., Maston, W. H., & Tang, L. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.6.2466 · Cited by 61 · see citing works

T‐CELL REGULATION OF IMMUNE RESPONSIVENESS*

MILLER, J. F. A. P. (1975) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1975.tb29052.x · Cited by 51 · see citing works

Letter: When is a mouse "old"?

Walford, R. L. (1976) · PubMed · Cited by 49 · see citing works

Nature of Cellular Deficiencies in Age-Related Decline of the Immune System

Heidrick, M. L., & Makinodan, T. (2009) · Gerontologia · doi:10.1159/000211942 · Cited by 48 · see citing works

When Is a Mouse “Old”?

Walford, R. L. (1976) · The Journal of Immunology · doi:10.4049/jimmunol.117.1.352 · Cited by 44 · see citing works

Nonlinear Response of the Reticuloendothelial System upon Stimulation

Bliznakov, E. G., & Adler, A. D. (2008) · Pathologia et Microbiologia · doi:10.1159/000162456 · Cited by 37 · see citing works

AGE DEPENDENCE OF T LYMPHOCYTES

Teasdale, C., Thatcher, J., Whitehead, R., & Hughes, L. E. (1976) · The Lancet · doi:10.1016/s0140-6736(76)93059-2 · Cited by 33 · see citing works

Reticuloendothelial system in health and disease: functions and characteristics

Reichard, S. M., Escobar, M. R., & Friedman, H. P. (1976) · OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) · Cited by 31 · see citing works

Age-related changes in B and T lymphocytes and decline of humoral immune responsiveness in aged mice

Segre, D., & Segre, M. (1977) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(77)90013-6 · Cited by 29 · see citing works

Restoration of some energy linked processes lost during the ageing of rat liver mitochondria

SILIPRANDI, D., Siliprandi, N., Scutari, G., & Zoccarato, F. (1973) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(73)91180-7 · Cited by 27 · see citing works

The potential of coenzyme Q 10 (NSC-140865) in cancer treatment.

Folkers, K. (1974) · PubMed · Cited by 22 · see citing works

Age-associated involution of cellular immune function. I. Accelerated decline of mitogen reactivity of spleen cells in adult thymectomized mice.

Pachciarz, J. A., & Teague, P. O. (1976) · PubMed · Cited by 21 · see citing works

Immunologic Control of Aging: a Possible Primary Event

Greenberg, L. J., & Yunis, E. J. (2009) · Gerontologia · doi:10.1159/000211939 · Cited by 18 · see citing works

Age-Associated Involution of Cellular Immune Function

Pachciarz, J. A., & Teague, P. O. (1976) · The Journal of Immunology · doi:10.4049/jimmunol.116.4.982 · Cited by 15 · see citing works

Aging and Immune Function

Adler, W. H. (1975) · BioScience · doi:10.2307/1297033 · Cited by 14 · see citing works

Immune function and dysfunction in relation to aging

Cheney, K. E., & Walford, R. L. (1974) · Life Sciences · doi:10.1016/0024-3205(74)90090-3 · Cited by 13 · see citing works

Immunostimulation or immunodepression?

Bliznakov, E. G. (1977) · PubMed · Cited by 10 · see citing works

“SIGNAL THEORY” IN CELLULAR IMMUNOLOGY: COLLABORATION BETWEEN T‐ AND B‐LYMPHOCYTES IN THE IMMUNE RESPONSE

Claman, H. N. (1975) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1975.tb29053.x · Cited by 9 · see citing works

From sharks to coenzyme Q10.

Bliznakov, E. G. (1976) · PubMed · Cited by 6 · see citing works

Age Influence on the Immune System

Makinodan, T., & Kay, M. M. B. (1980) · Advances in Immunology · doi:10.1016/s0065-2776(08)60047-4 · Cited by 699 · see citing works

The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence

Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works

Tissue coenzyme Q (ubiquinone) and protein concentrations over the life span of the laboratory rat

Beyer, R. E., Burnett, B.-A., Cartwright, K. J., Edington, D. W., Falzon, M. J., Kreitman, K. R., Kuhn, T. W., Ramp, B. J., Rhee, S. Y. S., Rosenwasser, M. J., et al. (1985) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(85)90085-5 · Cited by 119 · see citing works

Exploring alternatives to antibiotics as health promoting agents in poultry- a review

Yadav, A. S., Kolluri, G., Gopi, M., Karthik, K., Malik, Y. S., & Dhama, K. (2016) · Journal of Experimental Biology and Agricultural Sciences · doi:10.18006/2016.4(3s).368.383 · Cited by 120 · see citing works

Modification of mitochondrial respiration by aging and dietary restriction

Weindruch, R. H., Cheung, M. K., Verity, M. A., & Walford, R. L. (1980) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(80)90070-6 · Cited by 108 · see citing works

Coenzyme Q10 and Immune Function: An Overview

Mantle, D., Heaton, R. A., & Hargreaves, I. P. (2021) · Antioxidants · doi:10.3390/antiox10050759 · Cited by 84 · see citing works

Life span extension and cancer risk: myths and reality

Anisimov, V. V. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00114-0 · Cited by 78 · see citing works

Life Extension

Schneider, E. L., & Reed, J. D. (1985) · New England Journal of Medicine · doi:10.1056/nejm198505023121805 · Cited by 60 · see citing works

Effects of dietary L-carnitine and coenzyme Q10at different supplemental ages on growth performance and some immune response in ascites-susceptible broilers

Geng, A., Li, B., & Guo, Y. (2007) · Archives of Animal Nutrition · doi:10.1080/17450390601117041 · Cited by 52 · see citing works

Potential clinical applications for high-dose nutritional antioxidants.

Crary, E., & McCarty, M. (1984) · Medical Hypotheses · doi:10.1016/0306-9877(84)90132-4 · Cited by 48 · see citing works

Immunomodulatory effects of l-carnitine and q10 in mouse spleen exposed to low-frequency high-intensity magnetic field

Arafa, H. M. M., Abd‐Allah, A. R. A., EL-MAHDY, M. A., Ramadan, L. A. A., & Hamada, F. M. A. (2003) · Toxicology · doi:10.1016/s0300-483x(03)00050-7 · Cited by 31 · see citing works

Antibiotics Resistance in Poultry and its Solution

Samad, A. (2022) · Devotion Journal of Research and Community Service · doi:10.36418/dev.v3i10.206 · Cited by 25 · see citing works

Chapter 15 Immunostimulants

Dukor, P., Tarcsay, L., & Baschang, G. (1979) · Annual reports in medicinal chemistry · doi:10.1016/s0065-7743(08)61360-3 · Cited by 25 · see citing works

Potential Therapies in Aging and Senile Dementias*

Roberts, E. (1982) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1982.tb26851.x · Cited by 19 · see citing works

The Role of Coenzyme Q 10 in Clinical Medicine: Part I

Gaby, A. R. (1996) · Cited by 15 · see citing works

Coenzyme Q and Myocardial Function in Aging and Exercise

Beyer, R. E., & Starnes, J. W. (1985) · Developments in cardiovascular medicine · doi:10.1007/978-1-4613-2621-2_35 · Cited by 15 · see citing works

Rationales for micronutrient supplementation in diabetes

McCarty, M. F., & Rubin, E. J. (1984) · Medical Hypotheses · doi:10.1016/0306-9877(84)90025-2 · Cited by 14 · see citing works

Effects of Coenzyme Q10 on Rat Liver Cells under Conditions of Metabolic Stress

Vasiliev, A. V., Martinova, E. A., Sharanova, N. V., & Gapparov, M. M. G. (2011) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-011-1156-8 · Cited by 13 · see citing works

Suppression of Immunological Responsiveness in Aged Mice and Its Relationship with Coenzyme Q Deficiency

Bliznakov, E. G. (1980) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-3593-1_32 · Cited by 13 · see citing works

Role of the Immune System in Aging

Makinodan, T. (1980) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-3734-8_19 · Cited by 12 · see citing works

Coenzyme Q 10 and Neoplasia

Bliznakov, E. G., Chopra, R., & Bhagavan, H. N. (2004) · CRC series in modern nutrition science · doi:10.1201/9780203506707.ch36 · Cited by 8 · see citing works

Aging and Functions of the RES

Weindruch, R. H., & Walford, R. L. (1982) · Springer eBooks · doi:10.1007/978-1-4684-4166-6_21 · Cited by 4 · see citing works

The effect of coenzyme Q10 in comparison with placebo on CD4 in HIV-infected patients

Yousefi, F., & Roozbeh, F. (2018) · Clinical Epidemiology and Global Health · doi:10.1016/j.cegh.2018.10.001 · Cited by 1 · see citing works

Immunosenescence and CoQ10

Hernández‐Camacho, J. D., Meza-Torres, C., & López‐Lluch, G. (2020) · Springer eBooks · doi:10.1007/978-3-030-45642-9_13 · Cited by 1 · see citing works

Modulation of the immune response by antioxidants (a review)

Смирнов, Л. Д., & Сускова, В. С. (1989) · Pharmaceutical Chemistry Journal · doi:10.1007/bf00764651 · Cited by 1 · see citing works

CoQ10 Supplementation for Healthy Longevity

López‐Lluch, G. (2026) · Healthy ageing and longevity · doi:10.1007/978-3-032-11608-6_6

Coenzyme Q deficiency in aged mice.

Bliznakov, E. G., Watanabe, T., Saji, S., & Folkers, K. (1978) · PubMed · Cited by 10 · see citing works

Age-related changes in B and T lymphocytes and decline of humoral immune responsiveness in aged mice

Segre, D., & Segre, M. (1977) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(77)90013-6 · Cited by 29 · see citing works

Reduced Coenzyme Q10 Supplementation Decelerates Senescence in SAMP1 Mice

Yan, J., Fujii, K., Yao, J., Kishida, H., Hosoe, K., Sawashita, J., Takeda, T., Mori, M., & Higuchi, K. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2005.11.007 · Cited by 45 · see citing works

Reduced humoral immune activity in long-lived old mice: an approach to elucidating its mechanisms.

Makinodan, T., Albright, J. W., Good, P. I., Peter, C. P., & Heidrick, M. L. (1976) · PubMed Central · Cited by 67 · see citing works

Immunological senescence. I. The role of suppressor cells.

Roder, J., Duwe, A. K., Bell, D., & Singhal, S. K. (1978) · PubMed · Cited by 49 · see citing works