Age Influence on the Immune System
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Aging leads to a reduction in T cell function, plasticity and proliferation with subsequent impact on B cell populations, a phenomenon known as immunosenescence.
“Aging also leads to a reduction in T cell function, plasticity and proliferation with subsequent impact on B cell populations, a phenom enon known as 'immunosenescence ' (Makinodan and Kay, 1980; Lewis et al., 2022).”
From Gene Therapy-Associated Uveitis (GTAU): Understanding and mitigating the adverse immune response in retinal gene therapy (2025) · cites this paper as Makinodan and Kay, 1980
Cites
AGEING, IMMUNE RESPONSE, AND MORTALITY
Roberts-Thomson, I., Youngchaiyud, U., Whittingham, S., & Mackay, I. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91755-3 · Cited by 477 · see citing works
Immunological Senescence in Mice and Its Reversal by Coenzyme Q10
Bliznakov, E. G. (1978) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(78)90065-9 · Cited by 26 · see citing works
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Oxidants, antioxidants, and the degenerative diseases of aging.
Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7915 · Cited by 5,958 · see citing works
Rates and risk factors of liver fibrosis progression in patients with chronic hepatitis c
Poynard, T., Ratziu, V., Charlotte, F., Goodman, Z., McHutchison, J., & Albrecht, J. (2001) · Journal of Hepatology · doi:10.1016/s0168-8278(00)00097-0 · Cited by 749 · see citing works
Aging and cancer: The role of macrophages and neutrophils
Jackaman, C., Tomay, F., Duong, L., Abdol Razak, N. B., Pixley, F. J., Metharom, P., & Nelson, D. J. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.03.008 · Cited by 251 · see citing works
Son, N. H., Murray, S., Yanovski, J., Hodes, R. J., & Weng, N.-P. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.3.1191 · Cited by 200 · see citing works
Changes in apoptosis of human polymorphonuclear granulocytes with aging
Fülöp Jr, T., Fouquet, C., Allaire, P., Perrin, N., Lacombe, G., Stankova, J., Rola-Pleszczynski, M., Gagné, D., Wagner, J. R., Khalil, A., et al. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(96)01881-7 · Cited by 141 · see citing works
Chelvarajan, R. L., Collins, S. M., Van Willigen, J. M., & Bondada, S. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0804449 · Cited by 141 · see citing works
Pallast, E. G., Schouten, E. G., de Waart, F. G., Fonk, H. C., Doekes, G., von Blomberg, B. M., & Kok, F. J. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.6.1273 · Cited by 141 · see citing works
Vitamin E ingestion improves several immune functions in elderly men and women
De la Fuente, M., Hernanz, A., Guayerbas, N., Manuel Victor, V., & Arnalich, F. (2008) · Free Radical Research · doi:10.1080/10715760801898838 · Cited by 124 · see citing works
Effects of aging on early B‐ and T‐cell development
Min, H., Montecino‐Rodriguez, E., & Dorshkind, K. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00263.x · Cited by 96 · see citing works
Cumberbatch, M., Dearman, R. J., & Kimber, I. (2002) · Immunology · doi:10.1046/j.1365-2567.2002.01381.x · Cited by 78 · see citing works
Interleukin-2 production and activity in aged humans
Rabinowich, H., Goses, Y., Reshef, T., & Klajman, A. (1985) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(85)90081-8 · Cited by 73 · see citing works
Purdy, R., John, M., Bray, A., Clare, A. J., Copland, D. A., Chan, Y. K., Henderson, R. H., Nerinckx, F., Leroy, B. P., Yang, P., et al. (2025) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2025.101354 · Cited by 24 · see citing works
“Aging also leads to a reduction in T cell function, plasticity and proliferation with subsequent impact on B cell populations, a phenomenon known as ‘immunosenescence ’ (Makinodan and Kay, 1980; Lewis et al., 2022).”
- Authors
- Makinodan, T., & Kay, M. M. B.
- Affiliations
- University of California, Los Angeles (US)
- Venue
- Advances in Immunology
- Publisher
- Elsevier
- Published
- 1980
- Volume
- 29
- Pages
- 287-330
- ISSN
- 0065-2776 (ISSN-L)
- OpenAlex
- W167981432
- Cited by
- 699
- References
- 2
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 7 · 2019: 5 · 2018: 1 · 2017: 6 · 2016: 4 · 2015: 2 · 2014: 5 · 2013: 3 · 2012: 2
- FWCI
- 16.48
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Advances in immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- immunosenescence, aging, immune function decline, T cell function, B cell function, antibody production, autoantibodies, suppressor cells, cell-mediated immunity, immune cell subpopulations, cell loss, sexual maturity
- MeSH terms
- Aging, Animals, Antibody Formation, Antioxidants, Diet, Genes, Humans, Hypophysectomy, Immunity, Cellular, Levamisole, Lymph Nodes, Mercaptoethanol, Poly A-U, Spleen, Splenectomy, Thymus Gland, Thymus Hormones, Bone Marrow Transplantation, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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