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Cited by 754Aging and Gerontology ResearchGenetics, Aging, and Longevity in Model OrganismsT-cell and B-cell Immunology

The DOI matches its Crossref record; 8 of the 9 references it cites were found in a registry or an index.

Admission criteria for immunogerontological studies in man: The senieur protocol

Ligthart, Gerard J., Corberand, Joël X., Fournier, Catherine, Galanaud, Pierre, Hijmans, Willy, Kennes, Bernard, Müller-Hermelink, Hans K., Steinmann, Gerhard G.·1984·Mechanisms of Ageing and Development
DOI 10.1016/0047-6374(84)90152-0
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Abstract

Immunogerontological studies in man have often led to conflicting results. One of the main reasons is the selection of the subjects to be studied. Admission criteria such as "apparently healthy" or "without overt disease" seem insufficient to exclude underlying disease which might influence the immune system and thereby the results. In an attempt to solve this problem, the SENIEUR protocol described in this paper was developed by a working party in the framework of the EURAGE Concerted Action Programme on Ageing of the European Community. This protocol establishes strict admission criteria for immunogerontological studies in man based on clinical information and laboratory data, and it sets limits to pharmacological interference. The use of this protocol will lead to standardization between centers and also to a closer study of the influence of age as such on the immune system. These findings in the immunologically "optimally aged" can also serve as reference values for immunogerontological studies in subjects who do not meet the SENIEUR criteria. In this way the use of this protocol can contribute to the dissection of the influence of disease versus ageing on the immune system.

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Crossref · 10.1016/0047-6374(84)90152-0

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Show all 9 references

Research works printed but not linked: 3

  1. Tezabwala, 1983, Studies on cell mediated immunity in women using different fertility regulatory methods, J. Clin. Lab. Immunol., 10, 199
  2. de Viere, 1984, Immune senescence: I. Effect of age, sex and health state on human blood mononuclear subpopulations, Arch. Int. Gerontol.
  3. Kennes, 1984, Immune senescence: II. Effect of age, sex and health state on human lymphocyte functions, Arch. Int. Gerontol.

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Metadata

Authors
Ligthart, G. J., Corberand, J. X., Fournier, C., Galanaud, P., Hijmans, W., Kennes, B., Müller-Hermelink, H. K., & Steinmann, G. G.
Affiliations
  • Leiden University (NL)
  • Hôpital Necker-Enfants Malades (FR)
  • Université Paris-Sud (FR)
  • Christian-Albrechts-Universität zu Kiel (DE)
Corresponding author
Ligthart, Gerard J.
ORCID
Galanaud, Pierre
Venue
Mechanisms of Ageing and Development
Publisher
Elsevier BV
Published
1984-11
Volume
28
Issue
1
Pages
47-55
ISSN
0047-6374 (ISSN-L)
DOI
10.1016/0047-6374(84)90152-0
OpenAlex
W2037412303
Cited by
754
References
9
Citations by year
2026: 2 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 6 · 2021: 9 · 2020: 10 · 2019: 11 · 2018: 13 · 2017: 8 · 2016: 17 · 2015: 11 · 2014: 11 · 2013: 22 · 2012: 18
FWCI
13.79
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Mechanisms of Ageing and Development (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Developmental and Educational Psychology › Aging and Gerontology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
healthy aging, reference values, age-related immune changes
MeSH terms
Adult, Aged, Aging, Cardiovascular Diseases, Humans, Immunity, Infections, Inflammation, Lymphoproliferative Disorders, Neoplasms, Research Design

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