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Cited by 73T-cell and B-cell ImmunologyImmunotoxicology and immune responsesImmune Response and Inflammation

Interleukin-2 production and activity in aged humans

Rabinowich, H., Goses, Y., Reshef, T., Klajman, A.·1985·Mechanisms of Ageing and Development
DOI 10.1016/0047-6374(85)90081-8
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Abstract

Peripheral blood mononuclear cells (PBMC) from aged humans were found impaired in their ability to mount T mitogen induced proliferative responses and NK cell activity. The production of IL-2 in response to PHA has also been found decreased in the aged subjects. When the data from IL-2 production and cellular responsiveness of aged and young groups were pooled for regression analysis, a significant correlation was found both for mitogenic responses and NK activity. The reduced proliferative responses and NK cell activity can be enhanced by exposing them to exogenous IL-2. However, they were not fully reconstituted to the levels achieved in PBMC of the young subjects supplemented in vitro with IL-2. This would indicate that the reduced cellular responsiveness in aging may be related both to a defect of IL-2 receptor expression on T cells of aged subjects and to an impairment in the endogenous IL-2 synthesis in the aged individuals.

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Crossref · 10.1016/0047-6374(85)90081-8

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Authors
Rabinowich, H., Goses, Y., Reshef, T., & Klajman, A.
Affiliations
  • Tel Aviv University (IL)
  • Israel Institute for Biological Research (IL)
Corresponding author
Klajman, A.
Venue
Mechanisms of Ageing and Development
Publisher
Elsevier BV
Published
1985-11
Volume
32
Issue
2-3
Pages
213-226
ISSN
0047-6374 (ISSN-L)
DOI
10.1016/0047-6374(85)90081-8
OpenAlex
W2072529084
Cited by
73
References
57
Citations by year
2022: 2 · 2021: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2013: 1
FWCI
1.31
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Mechanisms of Ageing and Development (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
interleukin-2, aging, peripheral blood mononuclear cells, T cell proliferation, mitogen response, NK cell cytotoxicity, IL-2 receptor expression, immunosenescence
MeSH terms
Adult, Aged, Aging, Cell Line, Cells, Cultured, Cytotoxicity, Immunologic, Female, Humans, Interleukin-2, Killer Cells, Natural, Leukemia, Myeloid, Lymphocyte Activation, Lymphocytes, Male, Middle Aged, Monocytes

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