Cited by 4,994Antioxidant Activity and Oxidative StressRedox biology and oxidative stressTrace Elements in Health

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[1] Role of free radicals and catalytic metal ions in human disease: An overview

Halliwell, Barry, Gutteridge, John M.C.·1990·Methods in Enzymology

DOI 10.1016/0076-6879(90)86093-b

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Items 201–400 of 562

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LIPID PEROXIDATION IN RELATION TO PROSTACYCLIN AND THROMBOXANE PHYSIOLOGY AND PATHOPHYSIOLOGY
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The role of superoxide and hydroxyl radicals in the degradation of hyaluronic acid induced by metal ions and by ascorbic acid
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Effects of the 21-aminosteroid U74006F on posttraumatic spinal cord ischemia in cats
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Free radicals and singlet oxygen scavengers: Reaction of a peroxy-radical with β-carotene, diphenyl furan and 1,4-diazobicyclo(2,2,2)-octane
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A comparison of the distribution and electron acceptor specificities of xanthine oxidase and aldehyde oxidase
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Breathing 100% oxygen after global brain ischemia in Mongolian Gerbils results in increased lipid peroxidation and increased mortality.
Mickel, H. S., Vaishnav, Y. N., Kempski, O. S., von Lubitz, D., Weiss, J. F., & FEUERSTEIN, G. Z. (1987) · Stroke · doi:10.1161/01.str.18.2.426 · Cited by 173
The cytotoxic and mutagenic properties of cholesterol oxidation products
Sevanian, A., & Peterson, A. R. (1986) · Food and Chemical Toxicology · doi:10.1016/0278-6915(86)90295-4 · Cited by 173
Aspects to Consider When Detecting and Measuring Lipid Peroxidation
Gutteridge, J. M. C. (1986) · Free Radical Research Communications · doi:10.3109/10715768609083149 · Cited by 173
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The specificity of thiourea, dimethylthiourea and dimethyl sulphoxide as scavengers of hydroxyl radicals. Their protection of α1-antiproteinase against inactivation by hypochlorous acid
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Facilitation of Fe(II) antoxidation by Fe(III) complexing agents
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Self-perpetuating mechanisms of immunoglobulin G aggregation in rheumatoid inflammation.
Lunec, J., Blake, D. R., McCleary, S. J., Brailsford, S., & BACON, P. A. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112212 · Cited by 171
Superoxide dismutase activity of low molecular weight Cu2+‐chelates studied by pulse radiolysis
Brigelius, R., Spöttl, R., Bors, W., Lengfelder, E., Sarán, M., & Weser, U. (1974) · FEBS Letters · doi:10.1016/0014-5793(74)80428-x · Cited by 170
Cytotoxicity from Coupled Redox Cycling of Autoxidizing Xenobiotics and Metals: A Selective Critical Review and Commentary on Work‐in‐Progress
Borg, D. C., & Schaich, K. M. (1984) · Israel Journal of Chemistry · doi:10.1002/ijch.198400007 · Cited by 170
Stimulation of endogenous endonuclease activity in hepatocytes exposed to oxidative stress
McConkey, D. J., Hartzell, P., Nicotera, P., Wyllie, A. H., & Orrenius, S. (1988) · Toxicology Letters · doi:10.1016/0378-4274(88)90069-0 · Cited by 169
Lipid peroxidation products and antioxidant proteins in plasma and cerebrospinal fluid from multiple sclerosis patients
Hunter, M. I. S., Nlemadim, B. C., & Davidson, D. L. W. (1985) · Neurochemical Research · doi:10.1007/bf00988606 · Cited by 169
The action of defined oxygen-centred free radicals on human low-density lipoprotein
Bedwell, S., Dean, R. T., & Jessup, W. (1989) · Biochemical Journal · doi:10.1042/bj2620707 · Cited by 169
Production of active oxygen species (1O2 and O2⨪) by psoralens and ultraviolet radiation (320–400 nm)
Pathak, M. A., & Joshi, P. C. (1984) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(84)90018-7 · Cited by 168
The analogous mechanisms of enzymatic inactivation induced by ascorbate and superoxide in the presence of copper.
Shinar, E., Navok, T., & Chevion, M. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)43728-8 · Cited by 165
Malondialdehyde formation from lipid peroxides in the thiobarbituric acid test: the role of lipid radicals, iron salts, and metal chelators.
Gutteridge, J. M. C., & Quinlan, G. J. (1984) · PubMed · Cited by 162
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Cobalt(II) ion as a promoter of hydroxyl radical and possible ‘crypto-hydroxyl’ radical formation under physiological conditions. Differential effects of hydroxyl radical scavengers
Moorhouse, C. P., Halliwell, B. B., Grootveld, M. C., et al. (1985) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(85)90147-3 · Cited by 158
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Brain cell death following ischemia and reperfusion
Krause, G. S., White, B. C., Aust, S. D., et al. (1988) · Critical Care Medicine · doi:10.1097/00003246-198807000-00015 · Cited by 156
Ethylene formation from methional
Pryor, W. A., & Tang, R. H. (1978) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(78)91562-0 · Cited by 156
Stimulated arachidonate metabolism during foam cell transformation of mouse peritoneal macrophages with oxidized low density lipoprotein.
Yokode, M., Kita, T., Kikawa, Y., Ogorochi, T., Narumiya, S., & Kawai, C. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113377 · Cited by 156
Free-radical generation by copper ions and hydrogen peroxide. Stimulation by Hepes buffer
Simpson, J. A., Cheeseman, K. H., Smith, S. E., & Dean, R. T. (1988) · Biochemical Journal · doi:10.1042/bj2540519 · Cited by 156
Generation of nitrogen-chlorine oxidants by human phagocytes.
Test, S. T., Lampert, M. B., Ossanna, P. J., Thoene, J. G., & Weiss, S. J. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111544 · Cited by 154
The iron-binding and hydroxyl radical scavenging action of anti-inflammatory drugs
Aruoma, O. I., & Halliwell, B. B. (1988) · Xenobiotica · doi:10.3109/00498258809041682 · Cited by 154
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The role of iron in ascorbate-dependent deoxyribose degradation. Evidence consistent with a site-specific hydroxyl radical generation caused by iron ions bound to the deoxyribose molecule
Aruoma, O. I., Grootveld, M. C., & Halliwell, B. B. (1987) · Journal of Inorganic Biochemistry · doi:10.1016/0162-0134(87)80035-1 · Cited by 153
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Oxidants, oxidant drugs, and malaria
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Polynuclear complexes of iron and their biological implications
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Iron fortification: an update
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Xanthine oxidase activity in human tissues and its inhibition by allopurinol (4-hydroxypyrazolo[3,4-d] pyrimidine).
Watts, R. W. E., Watts, J. E. M., & Seegmiller, J. E. (1965) · PubMed · Cited by 151
Selective microdetermination of lipid hydroperoxides
Marshall, P. J., Warso, M. A., & Lands, W. E. M. (1985) · Analytical Biochemistry · doi:10.1016/0003-2697(85)90347-1 · Cited by 148
Manganese: Its Acquisition by and Function in the Lactic Acid Bacteria
Archibald, F. S. (1986) · CRC Critical Reviews in Microbiology · doi:10.3109/10408418609108735 · Cited by 147
The mechanism and physiotherapeutic relief of pain.
Shields, C. D. (1951) · PubMed · Cited by 147
Cytotoxic aldehydes originating from the peroxidation of liver microsomal lipids
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Radicals from “Good's” buffers
Grady, J. K., Chasteen, N. D., & Harris, D. C. (1988) · Analytical Biochemistry · doi:10.1016/0003-2697(88)90167-4 · Cited by 146
Formation of malonaldehyde from lipid oxidation products
Frankel, E. N., & Neff, W. E. (1983) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(83)90141-8 · Cited by 146
The effect of human serum transferrin and milk lactoferrin on hydroxyl radical formation from superoxide and hydrogen peroxide.
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THE IMPORTANCE OF IRON IN RHEUMATOID DISEASE
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Reaction of iron-EDTA chelates with the superoxide radical
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Thiol-dependent lipid peroxidation
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Polymorphonulcear leukocyte chemotaxis toward oxidized lipid components of cell membranes.
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The determination of dehydroascorbic acid and ascorbic acid in the serum and synovial fluid of patients with rheumatoid arthritis (RA).
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Hydroxyl-radical-induced iron-catalysed degradation of 2-deoxyribose. Quantitative determination of malondialdehyde
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Metal ions and oxygen radical reactions in human inflammatory joint disease
Halliwell, B. B., Gutteridge, J. M. C., & Blake, D. R. (1985) · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · doi:10.1098/rstb.1985.0171 · Cited by 143
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The inhibition of lipid autoxidation by human caeruloplasmin
Al-Timimi, D. J., & Dormandy, T. L. (1977) · Biochemical Journal · doi:10.1042/bj1680283 · Cited by 143
Oxygen-derived Free Radicals in the Pathogenesis of Parasitic Disease
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Formation of hydroxyl radicals in the presence of ferritin and haemosiderin. Is haemosiderin formation a biological protective mechanism?
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DNA- and Protein-Scission Activities of Ascorbate in the Presence of Copper Ion and a Copper-Peptide Complex
Chiou, S. (1983) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a134471 · Cited by 139
The antioxidant action of human extracellular fluids. Effect of human serum and its protein components on the inactivation of α1-antiproteinase by hypochlorous acid and by hydrogen peroxide
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A possible mechanism of the generation of singlet molecular oxygen in NADPH-dependent microsomal lipid peroxidation
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Antioxidant properties of caeruloplasmin towards iron‐ and copper‐dependent oxygen radical formation
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The mechanism of liver microsomal lipid peroxidation
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The role of superoxide and hydroxyl radicals in phospholipid peroxidation catalysed by iron salts
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Oxidant injury of cells.
Schraufstätter, I. U., Pa, H., Jackson, J. H., & Cochrane, C. C. (1987) · PubMed · Cited by 135
The ability of scavengers to distinguish OH· production in the iron-catalyzed Haber-Weiss reaction: Comparison of four assays for OH·
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MACROPHAGES AND ATHEROGENESIS
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Hydroxyl radical production from hydrogen peroxide and enzymatically generated paraquat radicals: Catalytic requirements and oxygen dependence
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Detection of peroxyl and alkoxyl radicals produced by reaction of hydroperoxides with rat liver microsomal fractions
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Production of Superoxide and Activity of Superoxide Dismutase in Rabbit Epididymal Spermatozoa
Holland, M. K., Álvarez, J. G., & Storey, B. T. (1982) · Biology of Reproduction · doi:10.1095/biolreprod27.5.1109 · Cited by 129
Formation of yellow, orange, and red pigments in the reaction of alk-2-enals with 2-thiobarbituric acid
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The role of iron in ferritin- and haemosiderin-mediated lipid peroxidation in liposomes
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Invited Commentary:Superoxide, Iron, Vascular Endothelium and Reperfusion Injury
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The role of iron chelates in hydroxyl radical production by rat liver microsomes, NADPH-cytochrome P-450 reductase and xanthine oxidase
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Biochemical mechanisms of liver injury
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The superoxide dismutase activity of iron complexes
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Generation of hydrogen peroxide, superoxide and hydroxyl radicals during the oxidation of dihydroxyfumaric acid by peroxidase
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Co-oxidation of luminol by hypochlorite and hydrogen peroxide implications for neutrophil chemiluminescence
Brestel, E. P. (1985) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(85)90631-x · Cited by 122
Direct demonstration that ferrous ion complexes of di- and triphosphate nucleotides catalyze hydroxyl free radical formation from hydrogen peroxide
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Ethylene formation by polymorphonuclear leukocytes. Role of myeloperoxidase.
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Superoxide-dependent formation of hydroxyl radicals in the presence of iron salts is a feasible source of hydroxy radicals in vivo
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Superoxide dismutase inhibits the superoxide‐driven Fenton reaction at two different levels
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Iron-load increases the susceptibility of rat hearts to oxygen reperfusion damage. Protection by the antioxidant (+)-cyanidanol-3 and deferoxamine.
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Biochemical requirements for singlet oxygen production by purified human myeloperoxidase.
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Acute Mountain Sickness
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Proarrhythmic effects of an oxygen-derived free radical generating system on action potentials recorded from guinea pig ventricular myocardium: a possible cause of reperfusion-induced arrhythmias.
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Studies on the oxygen radical mechanism involved in the small intestinal reperfusion damage
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Detection of the Production of Oxygen-Centered Free Radicals by Human Neutrophils Using Spin Trapping Techniques: A Critical Perspective
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Stimulated human neutrophils limit iron-catalyzed hydroxyl radical formation as detected by spin-trapping techniques.
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LIPID PEROXIDATION AND THE CYTOTOXICITY OF COPPER*
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Oxygen metabolism of Streptococcus mutans: uptake of oxygen and release of superoxide and hydrogen peroxide
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DNA-ferrous iron catalyzed hydroxyl free radical formation from hydrogen peroxide
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Effects of 4-hydroxynonenal on isolated hepatocytes. Studies on chemiluminescence response, alkane production and glutathione status
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Energy-dependent accumulation of iron by isolated rat liver mitochondria. Requirement of reducing equivalents and evidence for a unidirectional flux of Fe(II) across the inner membrane
Flatmark, T., & Romslo, I. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)41082-x · Cited by 105
The characterisation of thiobarbituric acid reactivity in human plasma and urine
Gutteridge, J. M. C., & Tickner, T. R. (1978) · Analytical Biochemistry · doi:10.1016/0003-2697(78)90838-2 · Cited by 105
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Mitochondrial iron not bound in heme and iron-sulfur centers. Estimation, compartmentation and redox state
Tangerås, A., Flatmark, T., Bäckström, D., & Ehrenberg, A. (1980) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(80)90035-3 · Cited by 105
Reactions of Radicals with Lecithin Bilayers
Barber, D. J. W., & Thomas, J. K. (1978) · Radiation Research · doi:10.2307/3574756 · Cited by 105
Formation of Hydroxyl Radicals from Hydrogen Peroxide and Iron Salts by Superoxide- and Ascorbate-Dependent Mechanisms: Relevance to the Pathology of Rheumatoid Disease
Rowley, D. A., & Halliwell, B. B. (1983) · Clinical Science · doi:10.1042/cs0640649 · Cited by 104
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The deoxyribose assay: an assay both for ‘free’ hydroxyl radical and for site-specific hydroxyl radical production
Gutteridge, J. M. C., & Halliwell, B. B. (1988) · Biochemical Journal · doi:10.1042/bj2530932 · Cited by 103
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The role of superoxide and hydroxyl radicals in the degradation of DNA and deoxyribose induced by a copperphenanthroline complex
Gutteridge, J. M. C., & Halliwell, B. B. (1982) · Biochemical Pharmacology · doi:10.1016/0006-2952(82)90136-8 · Cited by 103
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Cigarette tar causes single-strand breaks in DNA
Borish, E. T., Cosgrove, J. P., Church, D. F., Deutsch, W. A., & Pryor, W. A. (1985) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(85)90972-6 · Cited by 102
Superoxide dismutase and catalase: A possible role in established pancreatitis
Guice, K. S., Miller, D. E., Oldham, K. T., et al. (1986) · The American Journal of Surgery · doi:10.1016/0002-9610(86)90027-9 · Cited by 102
Studies on the metal-ion and lipoxygenase-catalysed breakdown of hydroperoxides using electron-spin-resonance spectroscopy
Davies, M. J., & Slater, T. F. (1987) · Biochemical Journal · doi:10.1042/bj2450167 · Cited by 102
On the Use of OH · Scavengers in Biological Systems
Czapski, G. (1984) · Israel Journal of Chemistry · doi:10.1002/ijch.198400005 · Cited by 99
Formation of Hydroxyl Radicals in Biological Systems. Does Myoglobin Stimulate Hydroxyl Radical Formation from Hydrogen Peroxide?
Puppo, A., & Halliwell, B. B. (1988) · Free Radical Research Communications · doi:10.3109/10715768809066910 · Cited by 99
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New mechanism for foam cell generation in atherosclerotic lesions.
Curtiss, L. K., Black, A. S., Takagi, Y., & Plow, E. F. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113081 · Cited by 98
Endocytosis of superoxide dismutase is required in order for the enzyme to protect hepatocytes from the cytotoxicity of hydrogen peroxide.
Kyle, M. E., Nakae, D., Sakaida, I., et al. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68992-6 · Cited by 97
Production of hydroxyl radicals from paraquat radicals and H2O2
Winterbourn, C. C. (1981) · FEBS Letters · doi:10.1016/0014-5793(81)80112-3 · Cited by 97
The experimental and clinical pathology of diene conjugation
Dormandy, T. L., & Wickens, D. G. (1987) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(87)90072-7 · Cited by 97
Malondialdehyde formation in stored plasma
Lee, D. M. (1980) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(80)80090-8 · Cited by 96
Free radicals and Dupuytren's contracture.
Murrell, G. A. C., Francis, M. J. O., & Bromley, L. (1987) · BMJ · doi:10.1136/bmj.295.6610.1373 · Cited by 96
Application of interferometry to reaction kinetics: hydrolysis of ethyl acetate
O’Brien, R. N., & Glasel, A. (1969) · Canadian Journal of Chemistry · doi:10.1139/v69-031 · Cited by 96
Reducing Compounds in Radioprotection and Radio-sensitization: Model Experiments Using Ascorbic Acid
Redpath, J. L., & WILLSON, R. L. (1973) · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · doi:10.1080/09553007314550051 · Cited by 96
The role of altered lipoproteins in the pathogenesis of atherosclerosis
Haberland, M. E., & Fogelman, A. M. (1987) · American Heart Journal · doi:10.1016/0002-8703(87)90635-1 · Cited by 96
THE GENERATION OF HYDROXYL RADICALS IN BIOLOGIC SYSTEMS: TOXICOLOGICAL ASPECTS
Cohen, G. (1978) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1978.tb06993.x · Cited by 95
Low-Level Chemiluminescence of Isolated Hepatocytes
Cadenas, E., Wefers, H., & Sies, H. (1981) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1981.tb05640.x · Cited by 93
DNA footprinting with hydroxyl radical
Tullius, T. D. (1988) · Nature · doi:10.1038/332663a0 · Cited by 91
Lactoferrin-catalysed hydroxyl radical production. Additional requirement for a chelating agent
Winterbourn, C. C. (1983) · Biochemical Journal · doi:10.1042/bj2100015 · Cited by 91
Oxygen-derived free radical damage in organ preservation: activity of superoxide dismutase and xanthine oxidase.
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Superoxide dismutase and catalase reduce infarct size in a porcine myocardial occlusion-reperfusion model
Näslund, U., Häggmark, S., Johansson, G., MARKLUND, S., Reiz, S., & Öberg, A. (1986) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(86)80294-2 · Cited by 90
Bleomycin‐detectable iron in serum from leukaemic patients before and after chemotherapy Therapeutic implications for treatment with oxidant‐generating drugs
Halliwell, B. B., Aruoma, O. I., Mufti, G. J., & Bomford, A. B. (1988) · FEBS Letters · doi:10.1016/0014-5793(88)81061-5 · Cited by 90
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Free Radical Damage of the Brain Following Ischemia
Kogure, K., Arai, H., Abe, K., et al. (1985) · Progress in brain research · doi:10.1016/s0079-6123(08)61987-1 · Cited by 89
Does the reaction of copper(I) with hydrogen peroxide give hydroxyl radicals? A study of aromatic hydroxylation
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The intracellular distribution of the radiocopper derived from ceruloplasmin and from albumin
Marceau, N., & ASPIN, N. (1973) · Biochimica et Biophysica Acta (BBA) - Protein Structure · doi:10.1016/0005-2795(73)90267-5 · Cited by 89
Iron Complexes and Their Reactivity in the Bleomycin Assay for Radical-Promoting Loosely-Bound Iron
Gutteridge, J. M. C., & Hou, Y. (1986) · Free Radical Research Communications · doi:10.3109/10715768609088066 · Cited by 89
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Topical Problems in the Biosynthesis of Red Blood Pigment
Franck, B. (1982) · Angewandte Chemie International Edition in English · doi:10.1002/anie.198203431 · Cited by 89
The properties of hydrogen peroxide production under hyperoxic and hypoxic conditions of perfused rat liver
Oshino, N., Jamieson, D., & Chance, B. (1975) · Biochemical Journal · doi:10.1042/bj1460053 · Cited by 88
Biochemistry of wounded plant tissues
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Age pigments and free radicals: fluorescent lipid complexes formed by iron- and copper-containing proteins
Gutteridge, J. M. C. (1985) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(85)90149-3 · Cited by 88
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Ethylene from 2-keto-4-thiomethyl butyric acid: The Haber-Weiss reaction
Diguiseppi, J., & Fridovich, I. (1980) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(80)90114-9 · Cited by 87
Superoxide‐dependent formation of hydroxyl radicals from NADH and NADPH in the presence of iron salts
Rowley, D. A., & Halliwell, B. B. (1982) · FEBS Letters · doi:10.1016/0014-5793(82)80214-7 · Cited by 87
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Hydroxylation of p-coumaric acid by horseradish peroxidase. The role of superoxide and hydroxyl radicals
Halliwell, B. B., & AHLUWALIA, S. (1976) · Biochemical Journal · doi:10.1042/bj1530513a · Cited by 87
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Reactions of the semiquinone free radicals of anti‐tumour agents with oxygen and iron complexes
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The protective action of superoxide dismutase on metal-ion catalysed peroxidation of phospholipids
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O2 radicals mediate reperfusion lung injury in ischemic O2-ventilated canine pulmonary lobe
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Protection against Superoxide Radicals in Rat Lens
Varma, S. D., Ets, T. K., & Richards, R. D. (2009) · Ophthalmic Research · doi:10.1159/000264915 · Cited by 85
Inactivation of α1 ‐antiproteinase by hydroxyl radicals The effect of uric acid
Aruoma, O. I., & Halliwell, B. B. (1989) · FEBS Letters · doi:10.1016/0014-5793(89)81166-4 · Cited by 85
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Role of hydrogen peroxide in the cytotoxicity of the xanthine/xanthine oxidase system
Link, E. M., & Riley, P. A. (1988) · Biochemical Journal · doi:10.1042/bj2490391 · Cited by 85
INCREASED NON-PROTEIN-BOUND IRON AND DECREASED PROTECTION AGAINST SUPEROXIDE-RADICAL DAMAGE IN CEREBROSPINAL FLUID FROM PATIENTS WITH NEURONAL CEROID LIPOFUSCINOSES
Gutteridge, J. C., Halliwell, B. B., Rowley, D. A., & Westermarck, T. (1982) · The Lancet · doi:10.1016/s0140-6736(82)90492-5 · Cited by 85
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The effect of inorganic iron on the thiobarbituric acid method for the determination of lipid peroxides
Wills, E. D. (1964) · Biochimica et Biophysica Acta (BBA) - Specialized Section on Lipids and Related Subjects · doi:10.1016/0926-6542(64)90016-2 · Cited by 84
Hydroxyl radical mediation of immune renal injury by desferrioxamine
Boyce, N., & Holdsworth, S. R. (1986) · Kidney International · doi:10.1038/ki.1986.260 · Cited by 84
Aromatic hydroxylation of phenylalanine as an assay for hydroxyl radicals: Application to activated human neutrophils and to the heme protein leghemoglobin
Kaur, H., Fagerheim, I., Grootveld, M. C., Puppo, A., & Halliwell, B. B. (1988) · Analytical Biochemistry · doi:10.1016/0003-2697(88)90456-3 · Cited by 82
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Evidence for the production of hydroxyl radicals from the adriamycin semiquinone and H2O2
Winterbourn, C. C. (1981) · FEBS Letters · doi:10.1016/0014-5793(81)81220-3 · Cited by 82
Superoxide and superoxide-dependent formation of hydroxyl radicals are important in oxygen toxicity
Halliwell, B. B. (1982) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(82)90003-2 · Cited by 82
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Activation of complement by hydroxyl radical in thermal injury.
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Analysis of cardiac membrane phospholipid peroxidation kinetics as malondialdehyde: Nonspecificity of thiobarbituric acid‐reactivity
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Biochemical mechanisms of cephaloridine nephrotoxicity: Time and concentration dependence of peroxidative injury
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Radiation effects on DNA. The Silvanus Thompson Memorial Lecture, April 1982
SCHOLES, G. (1983) · British Journal of Radiology · doi:10.1259/0007-1285-56-664-221 · Cited by 81
The behaviour of caeruloplasmin in stored human extracellular fluids in relation to ferroxidase II activity, lipid peroxidation and phenanthroline-detectable copper
Gutteridge, J. M. C., Winyard, P. G., Blake, D. R., Lunec, J., Brailsford, S., & Halliwell, B. B. (1985) · Biochemical Journal · doi:10.1042/bj2300517 · Cited by 81
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The generation of O2-by the interaction of the hemolytic agent, phenylhydrazine, with human hemoglobin.
Goldberg, B. D., & Stern, A. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)41732-8 · Cited by 80
Human copper-zinc superoxide dismutase complements superoxide dismutase-deficient Escherichia coli mutants.
Natvig, D. O., Imlay, K. R. C., Touati, D., & Hallewell, R. A. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47851-9 · Cited by 80
A survey of chemicals inducing lipid peroxidation in biological systems
Kappus, H. (1987) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(87)90062-4 · Cited by 80
The interaction of oxymyoglobin with hydrogen peroxide: The formation of ferrylmyoglobin at moderate excesses of hydrogen peroxide
Whitburn, K. D. (1987) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(87)90195-0 · Cited by 80
Inhibition of arachidonic acid-induced vasogenic brain edema by the non-glucocorticoid 21-aminosteroid U74006F
Hall, E. D., & Travis, M. A. (1988) · Brain Research · doi:10.1016/0006-8993(88)90782-2 · Cited by 79
The interaction of copper(II) and glycyl-l-histidyl-l-lysine, a growth-modulating tripeptide from plasma
Lau, S. J., & Sarkar, B. (1981) · Biochemical Journal · doi:10.1042/bj1990649 · Cited by 79
Bleomycin-detectable iron in knee-joint synovial fluid from arthritic patients and its relationship to the extracellular antioxidant activities of caeruloplasmin, transferrin and lactoferrin
Gutteridge, J. M. C. (1987) · Biochemical Journal · doi:10.1042/bj2450415 · Cited by 79
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The fenton reaction between ferrous‐diethylenetriaminepentaacetic acid and hydrogen peroxide
Cohen, G., & Sinet, P. M. (1982) · FEBS Letters · doi:10.1016/0014-5793(82)80455-9 · Cited by 77
Uric acid substantially enhances the free radical‐induced inactivation of alcohol dehydrogenase
Kittridge, K. J., & WILLSON, R. L. (1984) · FEBS Letters · doi:10.1016/0014-5793(84)81391-5 · Cited by 77
Trace elements in human health with special reference to selenium
Diplock, A. T. (1987) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/45.5.1313 · Cited by 76
Quantitation of lipid peroxidation products by gas chromatography-mass spectrometry
Hughes, H., Smith, C. V., Tsokos, J. O., & Mitchell, J. R. (1986) · Analytical Biochemistry · doi:10.1016/0003-2697(86)90127-2 · Cited by 76
Plasma antioxidants and lipid peroxidation products in Duchenne muscular dystrophy
Hunter, M. I. S., & Mohamed, J. (1986) · Clinica Chimica Acta · doi:10.1016/0009-8981(86)90273-1 · Cited by 76
PLASMA OXIPURINOL CONCENTRATIONS DURING ALLOPURINOL THERAPY
Emmerson, B. T., Gordon, R. B., Cross, M., et al. (1987) · Lara D. Veeken · doi:10.1093/rheumatology/26.6.445 · Cited by 75
Tumor-localizing and photosensitizing properties of the main components of hematoporphyrin derivative.
Evensen, J. F., Sommer, S., Moan, J. E., et al. (1984) · PubMed · Cited by 75
Hepatocytes and reticulocytes have different mechanisms for the uptake of iron from transferrin.
Thorstensen, K. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37467-2 · Cited by 74
Myeloperoxidase and singlet oxygen: a reappraisal
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Oxygen radical-induced erythrocyte hemolysis by neutrophils. Critical role of iron and lactoferrin.
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Lipid peroxidation and molecular damage to polyunsaturated fatty acids in rat liver. Recognition of two classes of hydroperoxides formed under conditions in vivo
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An ESR Investigation of the Reactions of Glutathione, Cysteine and Penicillamine Thiyl Radicals: Competitive Formation of RSO·, R·, RSSR, and RSS·
Becker, D. A., Swarts, S. G., Champagne, M. H., et al. (1988) · International Journal of Radiation Biology · doi:10.1080/09553008814551121 · Cited by 73
Iron-mediated induction of sister-chromatid exchanges by hydrogen peroxide and superoxide anion
Larramendy, M. L., Mello-Filho, A. C., Mello-Filho, A. C., et al. (1987) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(87)90086-8 · Cited by 73
Photo-deep level transient spectroscopy: A technique to study deep levels in heavily compensated semiconductors
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The endothelial cell as a metabolic and endocrine organ
Vane, J. R., Gryglewski, R. J., & Botting, R. M. (1987) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(87)90045-9 · Cited by 73
Light activation of fructose bisphosphatase in isolated spinach chloroplasts and deactivation by hydrogen peroxide
Charles, S. A., & Halliwell, B. B. (1981) · Planta · doi:10.1007/bf00395175 · Cited by 73
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Roles of Copper and ${\rm O}_{2}^{\overline{\cdot}}$ in the Radiation-Induced Inactivation of T7 Bacteriophage
Samuni, A., Chevion, M., & Czapski, G. (1984) · Radiation Research · doi:10.2307/3576330 · Cited by 72
The role of lipid peroxidation in the toxicity of foreign compounds to liver cells
Smith, M. T., Thor, H., & Orrenius, S. (1983) · Biochemical Pharmacology · doi:10.1016/0006-2952(83)90573-7 · Cited by 70
The kinetics and mechanism of metal‐catalyzed autoxidation
Waters, W. A. (1971) · Journal of the American Oil Chemists Society · doi:10.1007/bf02544654 · Cited by 70
Haemosiderin and tissue damage
Weir, M., Gibson, J. F., & Peters, T. J. (1984) · Cell Biochemistry and Function · doi:10.1002/cbf.290020402 · Cited by 70
Oxygen radical damage to DNA by rifamycin SV and copper ions
Quinlan, G. J., & Gutteridge, J. M. C. (1987) · Biochemical Pharmacology · doi:10.1016/0006-2952(87)90012-8 · Cited by 69
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Studies of the limited degradation of mucus glycoproteins. The effect of dilute hydrogen peroxide
Creeth, J. M., Cooper, B., DONALD, A. S. R., & Clamp, J. R. (1983) · Biochemical Journal · doi:10.1042/bj2110323 · Cited by 68
An Aromatic Hydroxylation Assay for Hydroxyl Radicals Utilizing High-Performance Liquid Chromatography (HPLC). Use to Investigate the Effect of Edta on the Fenton Reaction
Grootveld, M. C., Halliwell, B. B., & Hill, H. A. O. (1986) · Free Radical Research Communications · doi:10.3109/10715768609051634 · Cited by 68
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The role of calcium in the pathogenesis of experimental arteriosclerosis
Fleckenstein, A., Frey, M., Zorn, J., et al. (1987) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(87)90046-0 · Cited by 66
Superoxide dismutase: A cellular protective enzyme in bowel ischemia
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The generation of hydroxyl and alkoxyl radicals from the interaction of ferrous bipyridyl with peroxides
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Formation of hydroxyl radicals from the paraquat radical cation, demonstrated by a highly specific gas chromatographic technique. The role of superoxide radical anion, hydrogen peroxide, and glutathione reductase
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Effect of hydrogen peroxide on the initiation of microsomal lipid peroxidation
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Effects of Oxidative Stress Caused by Hyperoxia and Diquat. A Study in Isolated Hepatocytes
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Free-radical-mediated postischemic reperfusion injury in the kidney
Ratych, R. E., & Bulkley, G. B. (1986) · Journal of Free Radicals in Biology & Medicine · doi:10.1016/s0748-5514(86)80030-7 · Cited by 64
In Vitro Screening of Iron Chelators Using Models of Free Radical Damage
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Authors: Halliwell, B., & Gutteridge, J. M. C.
ORCID: Halliwell, Barry
Venue: Methods in Enzymology
Publisher: Elsevier
Published: 1990
Volume: 186
Pages: 1-85
ISSN: 0076-6879 (ISSN-L)
DOI: 10.1016/0076-6879(90)86093-b
OpenAlex: W1734082729
Cited by: 4,994
References: 562
Citations by year: 2026: 16 · 2025: 47 · 2024: 52 · 2023: 78 · 2022: 101 · 2021: 96 · 2020: 95 · 2019: 96 · 2018: 103 · 2017: 129 · 2016: 122 · 2015: 142 · 2014: 184 · 2013: 196 · 2012: 214
FWCI: 53.61
Type: book chapter
Language: en
Open access: closed
Locations: Methods in enzymology on CD-ROM/Methods in enzymology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords: free radicals, catalytic metal ions, transition metals, iron metabolism, copper metabolism, chelation therapy, lipid peroxidation, diene conjugation, thiobarbituric acid assay, oxidative damage, human disease, toxicology
MeSH terms: Disease, Free Radicals, Humans, Ions, Metals, Superoxides

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[1] Role of free radicals and catalytic metal ions in human disease: An overview

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