The DOI matches its Crossref record; 276 of the 277 references it cites were found in a registry or an index.
On the role of organized multienzyme systems in cellular metabolism: A general synthesis
Open accessOverview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“The crux of the metabolon is that groups of enzymes and/or proteins within metabolic pathways physically associate.”
From Adrenal Mitochondria and Steroidogenesis: From Individual Proteins to Functional Protein Assemblies (2016) · cites this paper as [26]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Methods of Theoretical Physics
Morse, P. M., Feshbach, H., & Hill, E. L. (1954) · American Journal of Physics · doi:10.1119/1.1933765 · Cited by 13,197
On the nature of allosteric transitions: A plausible model
Monod, J., Wyman, J., & Changeux, J.-P. (1965) · Journal of Molecular Biology · doi:10.1016/s0022-2836(65)80285-6 · Cited by 8,825
Sociobiology: The New Synthesis.
Lenski, G., & Wilson, E. O. (1976) · Social Forces · doi:10.2307/2576242 · Cited by 6,271
Evolutionary Rate at the Molecular Level
KIMURA, M. (1968) · Nature · doi:10.1038/217624a0 · Cited by 3,737
Adaptation and Natural Selection: A Critique of Some Current Evolutionary Thought
Williams, G. C. (2008) · Project Muse (Johns Hopkins University) · doi:10.1515/9781400820108 · Cited by 2,762
Moore, J. W., Pearson, R. G., & Frost, A. A. (1961) · Andalas University Repository (Andalas University) · Cited by 2,342
King, J. L., & Jukes, T. H. (1969) · Science · doi:10.1126/science.164.3881.788 · Cited by 1,768
Nonequilibrium Thermodynamics in Biophysics
Katchalsky, A., & Curran, P. F. (1965) · Harvard University Press eBooks · doi:10.4159/harvard.9780674494121 · Cited by 1,724
Structural chemistry and molecular biology
Rich, A., Davidson, N., & Pauling, L. C. (1968) · Medical Entomology and Zoology · Cited by 1,702
Evolution. The Modern Synthesis.
Huxley, J. S. (1942) · DigitalGeorgetown (Georgetown University Library) · Cited by 1,421
Research works printed but not linked: 66
- Allen, 1976, 73, 665
- Arroyo-Begovich, 1969, 64, 1072
- Atkinson, 1970, Vol. 1, 461
- Ayala, 1974, Amer. Scient., 62, 692
- Berlyn, 1969, J. Bacteriol., 99, 231, 10.1128/jb.99.1.222-230.1969 · DOI
- Bernhardt, 1972, 69, 1868
- Berquist, 1974, 71, 4352
- Boiteux, 1975, 72, 3829
- Brown, 1972, 69, 1467
- Brown, 1976, 73, 143
- Changeux, 1967, 57, 335
- Damjanovich, 1971, Vol. 6, 133
- Deneubourg, 1976, Insectes Sociaux
- Dixon, 1966, Vol. 2, 147
- Doy, 1968, Rev. pure appl. Chem., 18, 41
- Eigen, 1963, Adv. Enzymol., 25, 1
- 1976, 35, 2079
- Florkin, 1974, Vol. 29A, 1
- Fröhlich, 1975, 72, 4211
- Gaertner, 1971, 30, 1131
- Gaertner, 1970, Methods Enzymol., 17, 386
- Ghosh, 1974, Sub-Cell. Biochem., 3, 311
- Gibson, 1968, Bacteriol. Rev., 32, 465, 10.1128/br.32.4_pt_2.465-492.1968 · doi:10.1128/br.32.4_pt_2.465-492.1968
- Giles, 1967, 58, 1930
- Giles, 1967, 58, 1453
- Goethe, 1970, Oeuvres d'Histoire Naturelle, Jacob
- Goldbeter, 1973, 70, 3255
- Green, 1957, Harvey Lectures, 52, 177
- Green, 1973, 70, 904
- Huxley, 1869, Eiseley, 335
- Katchalski, 1971, Adv. Enzymol., 34, 445
- Kemeny, 1974, 71, 2655
- Kent, 1975, 72, 1712
- Kirschner, 1972, Vol. 29, 71
- Kozak, 1975, 72, 683
- Laidler, 1951, Archs. Biochem., 30, 226
- Likhtenshtein, 1966, Biofisika, 11, 24
- Lotka, 1922, 8, 147
- Lotka, 1945, Hum. Biol., 17, 167
- Low, 1975, 72, 3305
- L'vov, 1974, Biofizika, 19, 576
- Lynen, 1972, Vol. 29, 177
- Mosbach, 1976, FEBS Lett. (Suppl.), 62, E80
- Odum, 1955, Am. Scient., 43, 331
- Ortoleva, 1975, Vol. 29, 49
- Paley, 1822, Natural Theology, 184
- Prigogine, 1975, Vol. 29, 1
- Rashevsky, 1973, Vol. 3, 177
- Reed, 1970, Vol. 1, 213
- Somogyi, 1971, Acta biochim. biophys. Acad. Sci., Hung., 6, 289
- Somogyi, 1974, Acta biochim. biophys. Acad. Sci., Hung., 9, 175
- Somogyi, 1974, Acta biochim. biophys. Acad. Sci., Hung., 9, 185
- Somogyi, 1971, Acta biochim. biophys. Acad. Sci., Hung., 6, 353
- Somogyi, 1973, Acta biochim. biophys. Acad. Sci., Hung., 8, 153
- Srere, 1973, 70, 2534
- Stoops, 1975, 72, 1940
- Tata, 1971, Sub-Cell Biochem., 1, 83
- Telford, 1975, 72, 3054
- Tewari, 1973, Sub-Cell. Biochem., 2, 287
- Vallee, 1968, 59, 498
- Vegotsky, 1958, Enzymologia, 19, 143
- Wakil, 1966, 55, 880
- Wald, 1963, Vol. 3, 12
- Webb, 1963, Vol. 1
- Welch, 1975, 72, 4218
- Wyman, 1975, 72, 3983
Cited by
Items 201–260 of 260
Guns in rosettes: The Arabidopsis chemical weapons arsenal
Somssich, M., Kliebenstein, D. J., & Andersen, T. G. (2025) · PLANT PHYSIOLOGY · doi:10.1093/plphys/kiaf411 · Cited by 5
“In the late 1970s, the formation of supermolecular complexes, so-called metabolons, was proposed to allow tight metabolic flux between enzymes (Welch 1978; Srere 1984, 1985; Andersen 2012).”
The Organization of Cell Metabolism: A Historical Vignette
Welch, G. R., & Clegg, J. S. (1986) · Springer eBooks · doi:10.1007/978-1-4684-5311-9_1 · Cited by 3
Self-citationCommentary: a Complex Biological Oscillator
Schoffeniels, E. E. (1994) · Advances in chemical physics · doi:10.1002/9780470142790.ch15 · Cited by 3
Cyclic nucleotide phosphodiesterase and 5′-nucleotidase: A coupled system
Galoyan, A. A., Gurvits, B. Y., & Sharova, N. P. (1989) · Neurochemical Research · doi:10.1007/bf00965512 · Cited by 3
“A detailed analysis of the kinetic and thermodynamic aspects of such a facilitated catalysis in a multienzyme system has been described (5).”
On the stability of cognitive processes
Cervén, E. (1985) · Cellular and Molecular Life Sciences · doi:10.1007/bf02012565 · Cited by 3
Towards a unified theory of cancer initiation in the cell
Ladik, J. J. (2000) · Journal of Molecular Structure THEOCHEM · doi:10.1016/s0166-1280(00)00350-x · Cited by 3
Practical Determination of Control Coefficients in Metabolic Pathways
Canela, E. I., Cascante, M., & Franco, R. (1990) · Springer eBooks · doi:10.1007/978-1-4757-9856-2_12 · Cited by 3
Le Système de la Biochimie Comparée
Schoffeniels, E. E. (1991) · Archives of Physiology and Biochemistry · doi:10.3109/13813459109145902 · Cited by 3
Microviscosity and enzyme-ligand dissociation
Whittenburg, S. L. (1983) · Journal of Theoretical Biology · doi:10.1016/0022-5193(83)90329-6 · Cited by 2
Markov chain methods in enzyme kinetics
Kůrka, P., & Dvořák, I. (1982) · Mathematical Biosciences · doi:10.1016/0025-5564(82)90030-x · Cited by 2
Functional and evolutional implications of natural channel-enzyme fusion proteins
Song, J., Wu, B., & Beitz, E. (2011) · BioMolecular Concepts · doi:10.1515/bmc.2011.037 · Cited by 2
“This layout prevents diffusion of the compounds away from the catalytic centers and, thus, increases the efficiency of the metabolic pathway (26).”
BackgroundA Hitchhiker's Guide to Evolving Networks
Kurland, C. G., & Berg, O. G. (2010) · Wiley eBooks · doi:10.1002/9780470570418.ch17 · Cited by 2
Langner, M., Gutowicz, J., & Gomułkiewicz, J. (1986) · FEBS Letters · doi:10.1016/0014-5793(86)80257-5 · Cited by 2
Welch, G. R. (1989) · Journal of Molecular Liquids · doi:10.1016/0167-7322(89)80067-4 · Cited by 2
Self-citationTHE PRINCIPLE OF SPATIAL CORRELATION
Schoffeniels, E. E. (1980) · Elsevier eBooks · doi:10.1016/b978-0-08-024938-4.50011-2 · Cited by 2
Foldamers as Inhibitors of Aberrant Protein–Protein Interactions
Stillman, N. H., Dohoney, R. A., Baysah, C. Z., & Kumar, S. (2025) · Wiley eBooks · doi:10.1002/9783527845828.ch8 · Cited by 2
Organization and Control of Energy Metabolism in Anaerobic Microorganisms
Kell, D. B., & Walter, R. P. (1986) · Springer eBooks · doi:10.1007/978-1-4684-5311-9_22 · Cited by 2
MLOs and control of metabolic pathways
Arakawa, H. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823967-4.00023-3 · Cited by 1
Direct Transfer of Metabolites Via Enzyme-Enzyme Complexes: Evidence and Physiological Significance
Bernhard, S. A., & Srivastava, D. K. (1986) · Springer eBooks · doi:10.1007/978-1-4684-5311-9_14 · Cited by 1
Constructing Reliable Protein-Protein Interaction (PPI) Networks
Srihari, S., Yong, C. H., & Wong, L. (2017) · doi:10.1145/3064650.3064653 · Cited by 2
Facilitation of Enzyme Catalysis by Formation of Multienzyme Complexes
SALERNO, C., & Fasella, P. M. (1982) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-9281-5_20 · Cited by 1
Montoya, L. I. (2008) · Biblos-e Archivo (Universidad Autónoma de Madrid) · Cited by 1
Smooth Muscle Energy Metabolism: Cytosolic Compartmentation of Metabolism and Function
Paul, R. J. (1987) · Springer eBooks · doi:10.1007/978-1-4615-9492-5_16 · Cited by 1
Creatine kinase and protein kinase reactions of cardiac cell membranes*1
Saks, V. A. (1982) · Journal of Molecular and Cellular Cardiology · doi:10.1016/0022-2828(82)90123-7 · Cited by 1
Prasad, G. L., & Adiga, P. R. (1987) · Journal of Biosciences · doi:10.1007/bf02704706 · Cited by 1
Kinetics and Thermodynamics of Enzyme Action and Regulation
Keleti, T. (1980) · Springer eBooks · doi:10.1007/978-94-009-9035-7_17 · Cited by 1
Biology, physics, and fields: Metaphor or reality?
Welch, G. R. (1993) · Journal of Molecular Liquids · doi:10.1016/0167-7322(93)80016-o · Cited by 1
Self-citationPerturbation of cell-selfregulation through oncoproteins
Ladikm, J. J., & Seel, M. (2009) · International Journal of Quantum Chemistry · doi:10.1002/qua.560280723 · Cited by 1
Energetic Consequence of Dynamic Enzyme-Enzyme Interaction
Keleti, T. (1986) · Springer eBooks · doi:10.1007/978-1-4684-5311-9_15 · Cited by 1
Le systéme de la Biochimie comparée
Schoffeniels, E. E. (1989) · Archives Internationales de Physiologie et de Biochimie · doi:10.3109/13813458909105526 · Cited by 1
Morphology of ribosomes and polysomes
BIELKA, H. (1982) · Springer eBooks · doi:10.1007/978-3-642-68272-8_5 · Cited by 1
The Quantum Theory of Carcinogenesis — A Short Review
Ladik, J. J., & Otto, P. (1989) · Springer eBooks · doi:10.1007/978-94-009-2526-7_9 · Cited by 1
Enzyme Sequences in the Living Cell
Welch, G. R. (1978) · Springer eBooks · doi:10.1007/978-1-4684-6985-1_60
Self-citationThe Disturbance of Cell-Self-Regulation Due to Oncogene Activation and Antioncogene Inactivation
Ladik, J. J., & Förner, W. (1994) · Springer eBooks · doi:10.1007/978-3-642-78984-7_8
Organization of Glucose Metabolism: A Model of Compartments by Poly-Isozymic Complexes
Ureta, T., & Radojković, J. (1986) · Springer eBooks · doi:10.1007/978-1-4684-5311-9_13
Les bases moléculaires de l'écologie
Schoffeniels, E. E. (1984) · Biochemical Systematics and Ecology · doi:10.1016/0305-1978(84)90048-6
AN ANALOGICAL “THERMAL-FIELD” STRUCTURE FOR BIOLOGICAL SPACE-TIME
Welch, G. R. (1991) · Elsevier eBooks · doi:10.1016/b978-0-444-88903-4.50009-3
Self-citationOptimism for biomimetic chemistry
Wombacher, H. (1984) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(84)90101-4
PROTEOMIC ANALYSIS OF THE FLAVONOID BIOSYNTHETIC MACHINERY IN ARABIDOPSIS THALIANA
Vaghela, N. N., Lazăr, I., Helm, R. F., & Walker, R. A. (2007) · VTechWorks (Virginia Tech)
Structural Characterization of the Flavonoid Enzyme Complex
Dana, C. D. (2004) · VTechWorks (Virginia Tech)
Chapter 4 The organization of metabolic pathways in vivo
Rickey^Weilch, G. (1995) · Principles of medical biology · doi:10.1016/s1569-2582(06)80006-1
Ainsworth, S. (1986) · Biochemical Journal · doi:10.1042/bj2400811
Identifying Evolutionarily Conserved Protein Complexes
Srihari, S., Yong, C. H., & Wong, L. (2017) · doi:10.1145/3064650.3064658
Protein Complex Prediction in the Era of Systems Biology
Srihari, S., Yong, C. H., & Wong, L. (2017) · doi:10.1145/3064650.3064659
Introduction to Protein Complex Prediction
Srihari, S., Yong, C. H., & Wong, L. (2017) · doi:10.1145/3064650.3064652
Evaluating Protein Complex Prediction Methods
Srihari, S., Yong, C. H., & Wong, L. (2017) · doi:10.1145/3064650.3064655
Computational Methods for Protein Complex Prediction from PPI Networks
Srihari, S., Yong, C. H., & Wong, L. (2017) · doi:10.1145/3064650.3064654
Open Challenges in Protein Complex Prediction
Srihari, S., Yong, C. H., & Wong, L. (2017) · doi:10.1145/3064650.3064656
Identifying Dynamic Protein Complexes
Srihari, S., Yong, C. H., & Wong, L. (2017) · doi:10.1145/3064650.3064657
Mieap forms membraneless organelles to compartmentalize and facilitate cardiolipin metabolismPreprint
Ikari, N., Honjo, K., Sagami, Y., Nakamura, Y., & Arakawa, H. (2021) · Research Square · doi:10.21203/rs.3.rs-713092/v1
Srihari, S., Yong, C. H., & Wong, L. (2017) · doi:10.1145/3064650.3064660
(2006) · Elsevier eBooks · doi:10.1533/9781845691615.bibliography
(1984) · Elsevier eBooks · doi:10.1016/b978-0-08-026376-2.50015-6
Srihari, S., Yong, C. H., & Wong, L. (2017) · doi:10.1145/3064650.3064661
Srihari, S., Yong, C. H., & Wong, L. (2017) · doi:10.1145/3064650.3064651
Chauvet, G. A. (1986) · Elsevier eBooks · doi:10.1016/b978-0-08-041992-3.50031-7
Metabolic Control Analysis In Situ: Problems And Paradigms
Welch, G. R. (1996) · Advances in molecular and cell biology · doi:10.1016/s1569-2558(08)60317-3
Self-citationConformation Changes in the Assembly of the α2ß2 Complex Of Tryptophan Synthase
Lane, A. N., Paul, C. H., & Kirschner, K. (1984) · Springer eBooks · doi:10.1007/978-1-4757-5034-8_7
Some Aspects of Enzyme Organization in the Citric Acid Cycle
Weitzman, P. D. J., & Barnes, S. J. (1986) · Springer eBooks · doi:10.1007/978-1-4684-5311-9_19
Metadata
- Authors
- Welch, G. R.
- Affiliations
- The University of Texas Health Science Center at Houston (US)
- Corresponding author
- Welch, G.Rickey
- Venue
- Progress in Biophysics and Molecular Biology
- Publisher
- Elsevier BV
- Published
- 1978
- Volume
- 32
- Issue
- 2
- Pages
- 103-191
- ISSN
- 0079-6107 (ISSN-L)
- OpenAlex
- W2133890603
- Cited by
- 260
- References
- 277
- Citations by year
- 2025: 2 · 2024: 2 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 1 · 2017: 12 · 2016: 4 · 2015: 2 · 2014: 3 · 2012: 3
- FWCI
- 4.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 15716 d)
- Locations
- Progress in Biophysics and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Keywords
- multienzyme systems, enzyme organization, cellular metabolism, enzyme kinetics, metabolic networks
- MeSH terms
- Catalysis, Cells, Diffusion, Escherichia coli, Euglena gracilis, Biological Evolution, Fatty Acids, Kinetics, Mathematics, Mitochondria, Models, Biological, Multienzyme Complexes, Neurospora crassa, Prephenate Dehydratase, Protein Conformation, Pyruvate Dehydrogenase Complex, Saccharomyces cerevisiae, Tetrahydrofolates, Tryptophan Synthase, Fatty Acid Synthases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.