Morphine reduces social cohesion in rats
Abstract
The effect of low (1 mg/kg) doses of morphine on maintenance of physical proximity were evaluated in paired rats observed in a 4 square foot test arena. Morphine reliably reduced proximity maintenance time, and this was apparently not due to sedation, since the effect was unmodified by doses of amphetamine which substantially increased motor activity. The effects of naloxone were inconsistent on this measure of social motivation. In general, the results are consistent with the theoretical proposition that a brain neurochemical change which might lead to social attraction is the activation of endogenous opioid systems. When opiate activity is exogenously sustained, animals exhibit a subnormal tendency to be gregarious.
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Low-dose morphine reduces social contact in guinea pigs and rats.
“Low-dose morphine also reduces social contact in guinea pigs and rats (Herman and Panksepp 1978; Panksepp et al 1979).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Panksepp et al 1979
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- Authors
- Panksepp, J., Najam, N., & Soares, F.
- Affiliations
- Bowling Green State University (US)
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 1979-08
- Volume
- 11
- Issue
- 2
- Pages
- 131-134
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W2040234437
- Cited by
- 105
- References
- 16
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 2 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 3 · 2012: 3
- FWCI
- 6.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- morphine, social cohesion, social proximity, social motivation, endogenous opioid system, naloxone, gregariousness, amphetamine, sedation
- MeSH terms
- Amphetamine, Animals, Drug Interactions, Male, Morphine, Motor Activity, Social Behavior, Time Factors, Rats
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