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Cited by 531Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

Endogenous opioids and social behavior

Panksepp, J., Herman, B.H., Vilberg, T., Bishop, P., DeEskinazi, F.G.·1980·Neuroscience & Biobehavioral Reviews
DOI 10.1016/0149-7634(80)90036-6
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Abstract

Evidence for the hypothesis that brain-opioids mediate social affect and social attachments is summarized. Opiates and opioids are very effective in reducing social separation-induced distress vocalizations (DVs), in puppies, young guinea pigs and chicks, while opiate antagonists can increase DVs. In studies of specific social behaviors in rodents, morphine (at doses 1 mg/kg and below) decreases proximity maintenance time in socially housed animals, increased play, decreases maternal aggression but has no effect on pup retrieval. Naloxone reduces play and disrupts pup-retrieval, but has no consistent effect on proximity maintenance time of socially housed animals. In young rats tested in social learning situations, morphine delays and naloxone hasten extinction. These data are consistent with the proposition that brain opioids modulate social emotions and behaviors.

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Crossref · 10.1016/0149-7634(80)90036-6

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  • Social bonding is experienced as positively valent because it stimulates the endogenous production of μ-opioids during affiliative behaviour.

    “The brain opioid theory maintains that social bonding is experienced as positively valent because it stimulates the endogenous production of μ-opioids during affiliative behaviour [106–108].”

    From Five studies evaluating the impact on mental health and mood of recalling, reading, and discussing fiction (2022) · cites this paper as [106]

  • In rats, guinea pigs, sheep, and Rhesus macaques, acute opioid antagonists increase social need and care solicitation by offspring, while agonists decrease solicitation in rats and Rhesus macaques.

    “In rats, guinea pigs, sheep, and Rhesus macaques, acute administration of opioid antagonists increases social need and the solicitation for care by offspring, while agonists decrease solicitation in rats and Rhesus macaques (Panksepp et al 1980; Kalin et al 1988; Martel et al 1993; Panksepp et al 1994; Martel et al 1995; Shayit et al 2003).”

    From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Panksepp et al 1980

  • In puppies, opioid antagonists increase social solicitation for attention but reduce the comfort obtained from later social contact.

    “Similarly, social solicitation for attention in puppies is increased with opioid antagonists, although this same treatment reduces the comfort received from subsequent social contact (Panksepp et al 1980).”

    From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Panksepp et al 1980

  • A phenomenological resemblance between narcotic addiction and social attachment has been proposed: both display an initial attachment phase, a tolerance-development phase and similar symptoms upon withdrawal.

    “a phenomenological resemblance between narcotic addiction and social attachment has been proposed: both display an initial attachment phase, a tolerance-development phase and similar symptoms upon withdrawal (67).”

    From Neuroendocrinology of Parental Response to Baby‐Cry (2011) · cites this paper as [67]

  • The opioid system was involved in placebo effect on analgesia and social behavior.

    “and that the opioid system was involved in placebo effect on analgesia (48, 49) and social behavior (51).”

    From Placebo treatment facilitates social trust and approach behavior (2018) · cites this paper as [51]

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Authors
Panksepp, J., Herman, B. H., Vilberg, T., Bishop, P., & DeEskinazi, F. G.
Affiliations
Bowling Green State University (US)
ORCID
Bishop, P.
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
1980-12
Volume
4
Issue
4
Pages
473-487
ISSN
0149-7634 (ISSN-L)
DOI
10.1016/0149-7634(80)90036-6
OpenAlex
W2081153295
Cited by
531
References
70
Citations by year
2026: 11 · 2025: 10 · 2024: 15 · 2023: 9 · 2022: 19 · 2021: 16 · 2020: 18 · 2019: 11 · 2018: 10 · 2017: 13 · 2016: 19 · 2015: 10 · 2014: 14 · 2013: 23 · 2012: 14
FWCI
45.81
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
endogenous opioids, social behavior, social affect, social attachment, distress vocalizations, social separation, morphine, naloxone, opioid antagonists, play behavior, maternal aggression, pup retrieval, social learning, extinction, social emotions
MeSH terms
Aggression, Animals, Behavior, Animal, Endorphins, Humans, Maternal Behavior, Morphine, Naloxone, Oxymorphone, Receptors, Opioid, Social Behavior, Social Isolation

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