The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Animal model of depression: Pharmacological sensitivity of a hedonic deficit
Open accessAbstract
A reduction in sucrose and saccharine consumption following chronic stress is reported for the rat. This deficit may be related to consummatory deficits seen in endogenous depression. To further examine this state pharmacologically, stressed rats were treated with the antidepressant imipramine. Despite a general absence of appetitive effects (or in some cases mild anorexia) imipramine significantly restored saccharine consumption in a variety of tests. The pharmacological similarity of the deficit to the changes accompanying affective disorders further supports the potential applicability of the chronic stress model.
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Citations
Cites
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GUSTATORY NERVE IMPULSES IN RAT, CAT AND RABBIT
Pfaffmann, C. (1955) · Journal of Neurophysiology · doi:10.1152/jn.1955.18.5.429 · Cited by 279
Amitriptyline and scopolamine in an animal model of depression
Katz, R. J., & Hersh, S. I. (1981) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(81)90008-7 · Cited by 105
Self-citationRoth, K. A., & Katz, R. J. (1981) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(81)90006-3 · Cited by 73
Self-citationLiljestrand, G., & Zotterman, Y. (1954) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1954.tb01177.x · Cited by 56
Manic depressive syndrome: a physiologic disease.
Sh, K. (1966) · PubMed · Cited by 9
Cited by
Sorted by citations
Willner, P., Towell, A., Sampson, D., Sophokleous, S., & Muscat, R. (1987) · Psychopharmacology · doi:10.1007/bf00187257 · Cited by 1,993
Willner, P. (1997) · Psychopharmacology · doi:10.1007/s002130050456 · Cited by 1,832
Willner, P. (2005) · Neuropsychobiology · doi:10.1159/000087097 · Cited by 1,605
The validity of animal models of depression
Willner, P. (1984) · Psychopharmacology · doi:10.1007/bf00427414 · Cited by 1,404
Chronic mild stress-induced anhedonia: A realistic animal model of depression
Willner, P., Muscat, R., & Papp, M. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80194-0 · Cited by 1,160
Metadata
- Authors
- Katz, R. J.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Katz, Richard J.
- ORCID
- Katz, Richard J.
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 1982-06
- Volume
- 16
- Issue
- 6
- Pages
- 965-968
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W2099660163
- Cited by
- 480
- References
- 7
- Citations by year
- 2026: 8 · 2025: 18 · 2024: 21 · 2023: 22 · 2022: 16 · 2021: 20 · 2020: 22 · 2019: 20 · 2018: 20 · 2017: 17 · 2016: 16 · 2015: 11 · 2014: 26 · 2013: 15 · 2012: 18
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- animal models of depression, chronic stress, sucrose intake, imipramine, antidepressant sensitivity, anorexia, mood disorders
- MeSH terms
- Animals, Depressive Disorder, Disease Models, Animal, Drinking, Eating, Humans, Imipramine, Male, Motivation, Rats, Inbred Strains, Stress, Physiological, Rats
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