Cited by 480Neurotransmitter Receptor Influence on BehaviorStress Responses and CortisolTreatment of Major Depression

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Animal model of depression: Pharmacological sensitivity of a hedonic deficit

Open access

Katz, Richard J.·1982·Pharmacology Biochemistry and Behavior

Open this paper in CoChat — free account Open PDF

Abstract

A reduction in sucrose and saccharine consumption following chronic stress is reported for the rat. This deficit may be related to consummatory deficits seen in endogenous depression. To further examine this state pharmacologically, stressed rats were treated with the antidepressant imipramine. Despite a general absence of appetitive effects (or in some cases mild anorexia) imipramine significantly restored saccharine consumption in a variety of tests. The pharmacological similarity of the deficit to the changes accompanying affective disorders further supports the potential applicability of the chronic stress model.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/0091-3057(82)90053-3

Cites

7 of 7 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Computational Handbook of Statistics.
Crofts, A., Bruning, J. L., & Kintz, B. L. (1969) · Journal of the American Statistical Association · doi:10.2307/2283756 · Cited by 2,328
Endogenomorphic Depression
Klein, D. F. (1974) · Archives of General Psychiatry · doi:10.1001/archpsyc.1974.01760160005001 · Cited by 601
GUSTATORY NERVE IMPULSES IN RAT, CAT AND RABBIT
Pfaffmann, C. (1955) · Journal of Neurophysiology · doi:10.1152/jn.1955.18.5.429 · Cited by 279
Amitriptyline and scopolamine in an animal model of depression
Katz, R. J., & Hersh, S. I. (1981) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(81)90008-7 · Cited by 105
Self-citation
Further studies on a novel animal model of depression: Therapeutic effects of a tricyclic antidepressant
Roth, K. A., & Katz, R. J. (1981) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(81)90006-3 · Cited by 73
Self-citation
The Water Taste in Mammals.
Liljestrand, G., & Zotterman, Y. (1954) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1954.tb01177.x · Cited by 56
Manic depressive syndrome: a physiologic disease.
Sh, K. (1966) · PubMed · Cited by 9

Show all 7 references

Sorted by citations

Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant
Willner, P., Towell, A., Sampson, D., Sophokleous, S., & Muscat, R. (1987) · Psychopharmacology · doi:10.1007/bf00187257 · Cited by 1,993
Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation
Willner, P. (1997) · Psychopharmacology · doi:10.1007/s002130050456 · Cited by 1,832
Chronic Mild Stress (CMS) Revisited: Consistency and Behavioural-Neurobiological Concordance in the Effects of CMS
Willner, P. (2005) · Neuropsychobiology · doi:10.1159/000087097 · Cited by 1,605
The validity of animal models of depression
Willner, P. (1984) · Psychopharmacology · doi:10.1007/bf00427414 · Cited by 1,404
Chronic mild stress-induced anhedonia: A realistic animal model of depression
Willner, P., Muscat, R., & Papp, M. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80194-0 · Cited by 1,160
Depression, Stress, and Anhedonia: Toward a Synthesis and Integrated Model
Pizzagalli, D. A. (2014) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050212-185606 · Cited by 1,155
Cytokines for psychologists: Implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition.
Maier, S. F., & Watkins, L. R. (1998) · Psychological Review · doi:10.1037/0033-295x.105.1.83 · Cited by 1,130
The chronic mild stress (CMS) model of depression: History, evaluation and usage
Willner, P. (2017) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.08.002 · Cited by 959
Chronic Stress Causes Frontostriatal Reorganization and Affects Decision-Making
Dias-Ferreira, E., Sousa, J. C., Melo, I., Morgado, P., Mesquita, A. R., Cerqueira, J. J., Costa, R. M., & Sousa, N. (2009) · Science · doi:10.1126/science.1171203 · Cited by 858
Dopamine system dysregulation in major depressive disorders
Belujon, P., & Grace, A. A. (2017) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx056 · Cited by 754
Prefrontal cortex and depression
Pizzagalli, D. A., & Roberts, A. C. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01101-7 · Cited by 667
Alterations induced by gestational stress in brain morphology and behaviour of the offspring
Weinstock, M. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00018-1 · Cited by 791
Stress-Induced Anhedonia in Mice is Associated with Deficits in Forced Swimming and Exploration
Strekalova, T. V., Spanagel, R., Bartsch, D., Henn, F. A., & Gass, P. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300532 · Cited by 584
An animal model of anhedonia: attenuation of sucrose consumption and place preference conditioning by chronic unpredictable mild stress
Papp, M., Willner, P., & Muscat, R. (1991) · Psychopharmacology · doi:10.1007/bf02244188 · Cited by 542
Endotoxin produces a depressive-like episode in rats
Yirmiya, R. (1996) · Brain Research · doi:10.1016/0006-8993(95)01415-2 · Cited by 604
Neural Mechanisms of Stress Resilience and Vulnerability
Franklin, T. B., Saab, B. J., & Mansuy, I. M. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.016 · Cited by 500
Leptin: A potential novel antidepressant
Lu, X.-Y., Kim, C. S., Frazer, A., & Zhang, W. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508901103 · Cited by 446
Dendritic Spines in Depression: What We Learned from Animal Models
Qiao, H., Li, M.-X., Xu, C. S., Chen, H.-B., An, S.-C., & Ma, X. (2016) · Neural Plasticity · doi:10.1155/2016/8056370 · Cited by 460
Animal models of depression: An overview
Willner, P. (1990) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(90)90076-e · Cited by 431
Neurobiology of chronic mild stress: parallels to major depression
Hill, M. N., Hellemans, K. G. C., Verma, P., Gorzalka, B. B., & Weinberg, J. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.07.001 · Cited by 420
Social model of depression in mice of C57BL/6J strain
Kudryavtseva, N. N., Bakshtanovskaya, I. V., & Koryakina, L. A. (1991) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(91)90284-9 · Cited by 404
Animal models of major depression and their clinical implications
Czéh, B., Fuchs, E., Wiborg, O., & Simon, M. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.04.004 · Cited by 375
Animal models of psychiatric disorders
Koob, G. F., & Zimmer, A. (2012) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52002-9.00009-7 · Cited by 338
Stress, depression and the mesolimbic dopamine system
Cabib, S., & Puglisi‐Allegra, S. (1996) · Psychopharmacology · doi:10.1007/s002130050142 · Cited by 320
The leptin hypothesis of depression: a potential link between mood disorders and obesity?
Lu, X.-Y. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.10.010 · Cited by 314
Behavioral animal models of depression
Yan, H., Cao, X., Das, M. K., Zhu, X., & Gao, T. (2010) · Neuroscience Bulletin · doi:10.1007/s12264-010-0323-7 · Cited by 312
Animal Models of Depression: Utility for Transgenic Research
Porsolt, R. D. (2000) · Reviews in the Neurosciences · doi:10.1515/revneuro.2000.11.1.53 · Cited by 293
Chronic Mild Stress and Sucrose Consumption: Validity as a Model of Depression
Forbes, N., Stewart, C. A., Matthews, K., & REID, I. (1996) · Physiology & Behavior · doi:10.1016/s0031-9384(96)00305-8 · Cited by 288
Antidepressant treatment prevents chronic unpredictable mild stress-induced anhedonia as assessed by ventral tegmentum self-stimulation behavior in rats
Moreau, J., Jenck, F., Martin, J. R., Mortas, P., & Haefely, W. E. (1992) · European Neuropsychopharmacology · doi:10.1016/0924-977x(92)90035-7 · Cited by 250
Selecting an Appropriate Animal Model of Depression
Hao, Y., Ge, H., Sun, M., & Gao, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194827 · Cited by 257
Suppression of sucrose drinking by chronic mild unpredictable stress: A methodological analysis
Muscat, R., & Willner, P. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80192-7 · Cited by 233
Models of Depression: Unpredictable Chronic Mild Stress in Mice
Nollet, M., Guisquet, A. L., & Belzung, C. (2013) · Current Protocols in Pharmacology · doi:10.1002/0471141755.ph0565s61 · Cited by 246
Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression
Dang, H., Chen, Y., Liu, X., Wang, Q., Wang, L., Jia, W. W.-G., & Wang, Y. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.07.020 · Cited by 226
Sucrose consumption as an hedonic measure following chronic unpredictable mild stress
Matthews, K., Forbes, N., & Reid, I. (1995) · Physiology & Behavior · doi:10.1016/0031-9384(94)00286-e · Cited by 223
Chronic mild stress-induced anhedonia: Greater effect in a genetic rat model of depression
Puciłowski, O., Overstreet, D. H., Rezvani, A. H., & Janowsky, D. S. (1993) · Physiology & Behavior · doi:10.1016/0031-9384(93)90351-f · Cited by 219
Measuring behavior in mice with chronic stress depression paradigm
Strekalova, T., & Steinbusch, H. W. M. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.12.014 · Cited by 207
Behavioral effects of neuropeptides in rodent models of depression and anxiety
Rotzinger, S., Lovejoy, D. A., & Tan, L. A. (2010) · Peptides · doi:10.1016/j.peptides.2009.12.015 · Cited by 211
Making Sense of Rodent Models of Anhedonia
Scheggi, S., Montis, M. G. D., & Gambarana, C. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy083 · Cited by 220
Animal models of depression in drug discovery: A historical perspective
McArthur, R. A., & Borsini, F. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.06.005 · Cited by 214
Evaluation of the effects of chronic mild stressors on hedonic and physiological responses: sex and strain compared
Konkle, A. T. M., Baker, S. L., Kentner, A. C., Barbagallo, L. S.-M., Merali, Z., & Bielajew, C. H. (2003) · Brain Research · doi:10.1016/j.brainres.2003.08.047 · Cited by 208
Defeat followed by individual housing results in long-term impaired reward- and cognition-related behaviours in rats
von Frijtag, J. C., Reijmers, L. G. J. E., van der Harst, J. E., Leus, I. E., van den Bos, R., & Spruijt, B. M. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00300-4 · Cited by 201
Reliability of the chronic mild stress model of depression: A user survey
Willner, P. (2017) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.08.001 · Cited by 198
Re-evaluation of the interrelationships among the behavioral tests in rats exposed to chronic unpredictable mild stress
Hu, C., Luo, Y., Wang, H., Kuang, S., Liang, G., Yang, Y., Mai, S., & Yang, J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0185129 · Cited by 209
Inhibition of mitochondrial respiratory chain in brain of rats subjected to an experimental model of depression
Rezin, G. T., Cardoso, M. R., Gonçalves, C. L., Scaini, G., Fraga, D. B., Riegel, R. E., Comim, C. M., Quevedo, J., & Streck, E. L. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.09.012 · Cited by 197
Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats
Zhao, Z., Wang, W., Guo, H., & Zhou, D. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.06.030 · Cited by 187
In vivo antioxidant status: A putative target of antidepressant action
Zafir, A., Ara, A., & Banu, N. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.11.010 · Cited by 183
Adult Neurogenesis and Mental Illness
Schoenfeld, T. J., & Cameron, H. A. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.230 · Cited by 192
Chronic mild stress damages mitochondrial ultrastructure and function in mouse brain
Gong, Y. L., Chai, Y., Ding, J., Sun, X., & Hu, G. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.11.006 · Cited by 185
Regulation of dopamine system responsivity and its adaptive and pathological response to stress
Belujon, P., & Grace, A. A. (2015) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2014.2516 · Cited by 192
Neurobehavioral deficits in db/db diabetic mice
Sharma, A. N., Elased, K. M., Garrett, T. L., & Lucot, J. B. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.07.002 · Cited by 182
Sex-Specific and Strain-Dependent Effects of Early Life Adversity on Behavioral and Epigenetic Outcomes
Kundaković, M., Lim, S. C., Gudsnuk, K. M., & Champagne, F. A. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00078 · Cited by 179
Update in the methodology of the chronic stress paradigm: internal control matters
Strekalova, T., Couch, Y., Kholod, N., Boyks, M., Malin, D., Leprince, P., & Steinbusch, H. M. (2011) · Behavioral and Brain Functions · doi:10.1186/1744-9081-7-9 · Cited by 163
How to study anxiety and depression in rodent models of chronic pain?
Kremer, M., Becker, L. J., Barrot, M., & Yalçın, İ. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14686 · Cited by 176
Characterization of stress-induced long-term behavioural changes in rats: Evidence in favor of anxiety
van Dijken, H. H., Mos, J., der Heyden, J. A. M. V., & Tilders, F. J. H. (1992) · Physiology & Behavior · doi:10.1016/0031-9384(92)90375-c · Cited by 165
Chronic mild stress affects sucrose intake and sleep in rats
Grønli, J., Murison, R. C. C., Bjorvatn, B., Sørensen, E., Portas, C. M., & Ursin, R. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00252-3 · Cited by 163
Animal models of depression: Parallels and correlates to severe depression in humans
Jesberger, J. A., & Richardson, J. S. (1985) · Biological Psychiatry · doi:10.1016/0006-3223(85)90156-8 · Cited by 157
Endotoxin- or pro-inflammatory cytokine-induced sickness behavior as an animal model of depression: focus on anhedonia
De La Garza, R. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.016 · Cited by 153
Chronic treatment with celecoxib reverses chronic unpredictable stress-induced depressive-like behavior via reducing cyclooxygenase-2 expression in rat brain
Guo, J.-Y., Li, C.-Y., Ruan, Y.-P., Sun, M., Qi, X.-L., Zhao, B.-S., & Luo, F. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.03.076 · Cited by 148
Rodent tests of depression and anxiety: Construct validity and translational relevance
Gencturk, S., & Ünal, G. (2024) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-024-01171-2 · Cited by 160
Chronic mild stress paradigm as a rat model of depression: facts, artifacts, and future perspectives
Strekalova, T. V., Liu, Y., Kiselev, D., Khairuddin, S., Chiu, J. L. Y., Lam, J., Chan, Y., Pavlov, D., Proshin, A. T., Lesch, K., et al. (2022) · Psychopharmacology · doi:10.1007/s00213-021-05982-w · Cited by 152
Failure to Change Exploration or Saccharin Preference In Rats Exposed to Chronic Mild Stress
Harris, R. B. S. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00425-3 · Cited by 151
Effects of chronic social stress during lactation on maternal behavior and growth in rats
Nephew, B. C., & Bridges, R. S. (2011) · Stress · doi:10.3109/10253890.2011.605487 · Cited by 138
Behavioural characterisation of chronic unpredictable stress based on ethologically relevant paradigms in rats
Sequeira‐Cordero, A., Salas-Bastos, A., Fornaguera, J., & Brenes, J. C. (2019) · Scientific Reports · doi:10.1038/s41598-019-53624-1 · Cited by 151
Chronic mild stress for modeling anhedonia
Wiborg, O. (2013) · Cell and Tissue Research · doi:10.1007/s00441-013-1664-0 · Cited by 144
Ethopharmacology of imipramine in the forced-swimming test: gender differences
Barros, H. M. T., & Ferigolo, M. (1998) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(98)00029-3 · Cited by 137
Animal models of CNS disorders
McGonigle, P. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.06.016 · Cited by 142
Stressor-induced anhedonia in the mesocorticolimbic system
Zacharko, R. M., & Anisman, H. (1991) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80032-6 · Cited by 135
Selective effects of citalopram in a mouse model of stress-induced anhedonia with a control for chronic stress
Strekalova, T. V., Gorenkova, N., Shunk, E., Dolgov, O., & Bartsch, D. (2006) · Behavioural Pharmacology · doi:10.1097/00008877-200605000-00008 · Cited by 133
Sex differences and phase of light cycle modify chronic stress effects on anxiety and depressive-like behavior
Huynh, T. N., Krigbaum, A. M., Hanna, J. J., & Conrad, C. D. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.03.038 · Cited by 133
SIRT1 in forebrain excitatory neurons produces sexually dimorphic effects on depression-related behaviors and modulates neuronal excitability and synaptic transmission in the medial prefrontal cortex
Lei, Y., Wang, J., Wang, D., Li, C., Liu, B., Fang, X., You, J., Guo, M., & Lu, X.-Y. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0352-1 · Cited by 131
Physical and emotional stress have differential effects on preference for saccharine and open field behaviour in rats
Buisman‐Pijlman, F. T. A., Wolterink, G., & van Ree, J. M. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00124-9 · Cited by 128
Sucrose Preference Test as a Measure of Anhedonic Behavior in a Chronic Unpredictable Mild Stress Model of Depression: Outstanding Issues
Markov, D. D. (2022) · Brain Sciences · doi:10.3390/brainsci12101287 · Cited by 133
Chronic variable stress and partial 5-HT denervation by parachloroamphetamine treatment in the rat: Effects on behavior and monoamine neurochemistry
Harro, J., Tõnissaar, M., Eller, M., Kask, A., & Oreland, L. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02256-9 · Cited by 124
Dopaminergic mechanism of imipramine action in an animal model of depression
Muscat, R., Sampson, D., & Willner, P. (1990) · Biological Psychiatry · doi:10.1016/0006-3223(90)90577-o · Cited by 126
Social Isolation-Induced Aggression Potentiates Anxiety and Depressive-Like Behavior in Male Mice Subjected to Unpredictable Chronic Mild Stress
Ma, X., Jiang, D., Jiang, W., Wang, F., Jia, M., Wu, J., Hashimoto, K., Dang, Y., & Gao, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020955 · Cited by 118
Effect of repeated novel stressors on depressive behavior and brain norepinephrine receptor system in Sprague-Dawley and Wistar Kyoto (WKY) rats
Tejani‐Butt, S. M., Paré, W. P., & Yang, J. (1994) · Brain Research · doi:10.1016/0006-8993(94)91045-6 · Cited by 116
Intracranial self-stimulation and sucrose intake differ as hedonic measures following chronic mild stress: interstrain and interindividual differences
Nielsen, C. K., Arnt, J., & Sánchez, C. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00110-2 · Cited by 119
Reversal of antidepressant action by dopamine antagonists in an animal model of depression
Sampson, D., Willner, P., & Muscat, R. (1991) · Psychopharmacology · doi:10.1007/bf02245655 · Cited by 116
Role of Mesolimbic Brain-Derived Neurotrophic Factor in Depression
Koo, J. W., Chaudhury, D., Han, M.-H., & Nestler, E. J. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.05.020 · Cited by 112
Animal models of pain: Diversity and benefits
Abboud, C., Duveau, A., Bouali‐Benazzouz, R., Massé, K. L., Mattar, J., Brochoire, L., Fossat, P., Boué‐Grabot, É., Hleihel, W., & Landry, M. (2020) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2020.108997 · Cited by 114
SMARCA3, a Chromatin-Remodeling Factor, Is Required for p11-Dependent Antidepressant Action
Oh, Y., Gao, P., Lee, K.-W., Ceglia, I., Seo, J., Zhang, X., Ahn, J., Chait, B. T., Patel, D. J., Kim, Y. D., et al. (2013) · Cell · doi:10.1016/j.cell.2013.01.014 · Cited by 114
Effect of chronic unpredictable mild stress on brain–pancreas relative protein in rat brain and pancreas
Lin, Y., Liu, A., Xu, Y., Tie, L., Yu, H., & Li, X.-J. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.06.034 · Cited by 110
Animal models of depression: pros and cons
Harro, J. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2973-0 · Cited by 110
Citalopram counteracts depressive-like symptoms evoked by chronic social stress in rats
Rygula, R., Abumaria, N., Flügge, G., Hiemke, C., Fuchs, E., Rüther, E., & Havemann-Reinecke, U. (2006) · Behavioural Pharmacology · doi:10.1097/01.fbp.0000186631.53851.71 · Cited by 104
GABAB Receptors and Depression: Current Status
Cryan, J. F., & Slattery, D. A. (2010) · Advances in pharmacology · doi:10.1016/s1054-3589(10)58016-5 · Cited by 106
HPA Axis Interactions with Behavioral Systems
Packard, A. E. B., Egan, A. E., & Ulrich‐Lai, Y. M. (2016) · Comprehensive physiology · doi:10.1002/cphy.c150042 · Cited by 136
Binge alcohol drinking elicits persistent negative affect in mice
Lee, K. M., Coehlo, M. A., McGregor, H. A., Waltermire, R. S., & Szumlinski, K. K. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.05.055 · Cited by 96
Ethanol‐induced conditioned taste aversion in male Sprague‐Dawley rats: impact of age and stress
Anderson, R. I., Varlinskaya, E. I., & Spear, L. P. (2010) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01307.x · Cited by 96
Rats with persistently low or high exploratory activity: Behaviour in tests of anxiety and depression, and extracellular levels of dopamine
Mällo, T., O’Leary, A., Kõiv, K., Tõnissaar, M., Eller, M., & Harro, J. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.11.022 · Cited by 98
Reduction in preference for saccharin by repeated unpredictable stress in mice and its prevention by imipramine
Harkin, A., Houlihan, D. D., & Kelly, J. P. (2002) · Journal of Psychopharmacology · doi:10.1177/026988110201600201 · Cited by 102
Animal Behavioural Studies in the Evaluation of Antidepressant Drugs
Thiébot, M.-H., Martin, P., & Puech, A. J. (1992) · The British Journal of Psychiatry · doi:10.1192/s0007125000296670 · Cited by 99
Chronic mild unpredictable stress after noradrenergic denervation: attenuation of behavioural and biochemical effects of DSP-4 treatment
Harro, J., Häidkind, R., Harro, M., Modiri, A., Gillberg, P., Pähkla, R., Matto, V., & Oreland, L. (1999) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(99)00043-7 · Cited by 96
Early exposure to chronic variable stress facilitates the occurrence of anhedonia and enhanced emotional reactions to novel stressors: reversal by naltrexone pretreatment
Zurita, A., Martijena, I. D., Cuadra, G. R., Brandão, M. L., & Molina, V. A. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00302-8 · Cited by 95
Prenatal stress programs neuroendocrine stress responses and affective behaviors in second generation rats in a sex-dependent manner
Grundwald, N. J., & Brunton, P. J. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.08.010 · Cited by 98
Environmental enrichment reverses the detrimental action of early inconsistent stimulation and increases the beneficial effects of postnatal handling on shuttlebox learning in adult rats
Escorihuela, R. M., Tobeña, A., & Fernández‐Teruel, A. (1994) · Behavioural Brain Research · doi:10.1016/0166-4328(94)90157-0 · Cited by 94
Isolation rearing impairs the reinforcing efficacy of intravenous cocaine or intra-accumbensd-amphetamine: impaired response to intra-accumbens D1 and D2/D3 dopamine receptor antagonists
Phillips, G. D., Howes, S. R., Whitelaw, R. B., Robbins, T. W., & Everitt, B. J. (1994) · Psychopharmacology · doi:10.1007/bf02245085 · Cited by 91
Behavioral and physiological effects of chronic mild stress in female rats
Baker, S. L., Kentner, A. C., Konkle, A. T. M., Barbagallo, L. S.-M., & Bielajew, C. H. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.10.019 · Cited by 92
Preventive Action of Kai Xin San Aqueous Extract on Depressive-Like Symptoms and Cognition Deficit Induced by Chronic Mild Stress
Dang, H., Sun, L., Liu, X., Peng, B., Wang, Q., Jia, W. W.-G., Chen, Y., Pan, A., & Xiao, P. (2009) · Experimental Biology and Medicine · doi:10.3181/0812-rm-354 · Cited by 93
Effects of vortioxetine and fluoxetine on the level of Brain Derived Neurotrophic Factors (BDNF) in the hippocampus of chronic unpredictable mild stress-induced depressive rats
Lu, Y., Ho, C. S. H., McIntyre, R. S., Wang, W., & Ho, R. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.06.007 · Cited by 91
Chronic Unpredictable Mild Stress Model of Depression: Possible Sources of Poor Reproducibility and Latent Variables
Markov, D. D., & Novosadova, E. V. (2022) · Biology · doi:10.3390/biology11111621 · Cited by 101

Authors: Katz, R. J.
Affiliations: University of Michigan (US)
Corresponding author: Katz, Richard J.
ORCID: Katz, Richard J.
Venue: Pharmacology Biochemistry and Behavior
Publisher: Elsevier BV
Published: 1982-06
Volume: 16
Issue: 6
Pages: 965-968
ISSN: 0091-3057 (ISSN-L)
DOI: 10.1016/0091-3057(82)90053-3
OpenAlex: W2099660163
Cited by: 480
References: 7
Citations by year: 2026: 8 · 2025: 18 · 2024: 21 · 2023: 22 · 2022: 16 · 2021: 20 · 2020: 22 · 2019: 20 · 2018: 20 · 2017: 17 · 2016: 16 · 2015: 11 · 2014: 26 · 2013: 15 · 2012: 18
FWCI: 0.56
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacology Biochemistry and Behavior (publishedVersion)
PubMed (publishedVersion)
Deep Blue (University of Michigan) (submittedVersion)
Funders: National Institute of Mental Health
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: animal models of depression, chronic stress, sucrose intake, imipramine, antidepressant sensitivity, anorexia, mood disorders
MeSH terms: Animals, Depressive Disorder, Disease Models, Animal, Drinking, Eating, Humans, Imipramine, Male, Motivation, Rats, Inbred Strains, Stress, Physiological, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Animal model of depression: Pharmacological sensitivity of a hedonic deficit

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks