Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant

Comparison of two modes of stress measurement: Daily hassles and uplifts versus major life events

Kanner, A. D., Coyne, J. C., Schaefer, C. A., & Lazarus, R. S. (1981) · Journal of Behavioral Medicine · doi:10.1007/bf00844845 · Cited by 3,128 · see citing works

The validity of animal models of depression

Willner, P. (1984) · Psychopharmacology · doi:10.1007/bf00427414 · Cited by 1,415 · see citing works

Acute and chronic stress effects on open field activity in the rat: Implications for a model of depression

Katz, R. J., Roth, K. A., & Carroll, B. J. (1981) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(81)90005-1 · Cited by 889 · see citing works

A review of psychoendocrine research on the pituitary–adrenal cortical system

MASON, J. W. (1968) · Psychosomatic Medicine · doi:10.1097/00006842-196809000-00020 · Cited by 874 · see citing works

Animal model of depression: Pharmacological sensitivity of a hedonic deficit

Katz, R. J. (1982) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(82)90053-3 · Cited by 480 · see citing works

Stress and Depression

Aneshensel, C. S. (1982) · Archives of General Psychiatry · doi:10.1001/archpsyc.1982.04290120028005 · Cited by 418 · see citing works

Social-environmental factors in unipolar depression: Comparisons of depressed patients and nondepressed controls.

Billings, A. G., Cronkite, R. C., & Moos, R. H. (1983) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.92.2.119 · Cited by 362 · see citing works

RADIOIMMUNOASSAY OF STEROIDS

MIDGLEY, A. R., & NISWENDER, G. D. (1970) · European Journal of Endocrinology · doi:10.1530/acta.0.065s320 · Cited by 268 · see citing works

Habituation to repeated stress is stressor specific

Jean Kant, G., Eggleston, T., Landman-Roberts, L., Kenion, C. C., Driver, G. C., & Meyerhoff, J. L. (1985) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(85)90286-2 · Cited by 225 · see citing works

Amitriptyline, Weight Gain and Carbohydrate Craving: A Side Effect

Paykel, E. S., Mueller, P. S., & la Vergne, P. M. D. (1973) · The British Journal of Psychiatry · doi:10.1192/bjp.123.5.501 · Cited by 216 · see citing works

Depression: A Psychobiological Synthesis

Willner, P. (1985) · Medical Entomology and Zoology · Cited by 197 · see citing works

Conditioned taste aversions: Two-stimulus tests are more sensitive than one-stimulus tests

Grote, F. W., & Brown, R. T. (1971) · Behavior Research Methods · doi:10.3758/bf03209955 · Cited by 172 · see citing works

Increased Intracranial Self-Stimulation in Rats After Long-Term Administration of Desipramine

Fibiger, H. C., & Phillips, A. G. (1981) · Science · doi:10.1126/science.7197394 · Cited by 154 · see citing works

Post-amphetamine depression of self-stimulation responding from the substantia nigra: Reversal by tricyclic antidepressants

Kokkinidis, L., Zacharko, R. M., & Predy, P. A. (1980) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(80)90242-7 · Cited by 109 · see citing works

Depressive reactions and unemployment.

Feather, N. T., & Barber, J. G. (1983) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.92.2.185 · Cited by 103 · see citing works

Amitriptyline and scopolamine in an animal model of depression

Katz, R. J., & Hersh, S. I. (1981) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(81)90008-7 · Cited by 101 · see citing works

Norepinephrine, clonidine, and tricyclic antidepressants selectively stimulate carbohydrate ingestion through noradrenergic system of the paraventricular nucleus

LEIBOWITZ, S. F., Brown, O., Tretter, J. R., & Kirschgessner, A. (1985) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(85)90416-2 · Cited by 86 · see citing works

Further studies on a novel animal model of depression: Therapeutic effects of a tricyclic antidepressant

Roth, K. A., & Katz, R. J. (1981) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(81)90006-3 · Cited by 73 · see citing works

Biochemical and behavioral correlates of chronic stress: Effects of tricyclic antidepressants

Soblosky, J. S., & Thurmond, J. B. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90196-6 · Cited by 63 · see citing works

Animal model of depression: Tests of three structurally and pharmacologically novel antidepressant compounds

Katz, R. J., & Sibel, M. (1982) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(82)90055-7 · Cited by 62 · see citing works

Animal model of depression: Effects of electroconvulsive shock therapy

Katz, R. J. (1981) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(81)90009-9 · Cited by 58 · see citing works

Amphetamine and tranylcypromine in an animal model of depression: Pharmacological specificity of the reversal effect

Katz, R. J., Roth, K. A., & Schmaltz, K. (1981) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(81)90007-5 · Cited by 57 · see citing works

A further parametric study of imipramine in an animal model of depression

Katz, R. J., & Baldrighi, G. (1982) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(82)90054-5 · Cited by 55 · see citing works

Prevention of stressor-induced disturbances of self-stimulation by desmethylimipramine

Zacharko, R. M., Bowers, W. J., Kelley, M. S., & Anisman, H. (1984) · Brain Research · doi:10.1016/0006-8993(84)90697-8 · Cited by 54 · see citing works

Angiotensin, thirst, and sodium appetite: retrospect and prospect.

Fitzsimons, J. T. (1978) · PubMed · Cited by 46 · see citing works

Further analysis of the specificity of a novel animal model of depression—effects of an antihistaminic, antipsychotic and anxiolytic compound

Katz, R. J., & Sibel, M. (1982) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(82)90056-9 · Cited by 36 · see citing works

Effects of peripheral 5-HT on consumption of flavoured solutions

Montgomery, A. M. J., & Burton, M. J. (1986) · Psychopharmacology · doi:10.1007/bf00652252 · Cited by 35 · see citing works

Effects of chronic lithium, amitriptyline and mianserin on glucoregulation, corticosterone and energy balance in the rat

Storlien, L. H., Higson, F. M., Gleeson, R. M., et al. (1985) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(85)90494-0 · Cited by 25 · see citing works

Self-stimulation responses are altered following long-term but not short-term treatment with clorgyline

Aulakh, C. S., Rm, C., Pradhan, S. N., et al. (1983) · Brain Research · doi:10.1016/0006-8993(83)90620-0 · Cited by 24 · see citing works

Effects of zometapine, A structurally novel antidepressant, in an animal model of depression

Katz, R. J. (1984) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(84)80027-1 · Cited by 22 · see citing works

Endocrine control of psychomotor activity in the rat: Effects of chronic dexamethasone upon general activity

KATZ, R., & CARROLL, B. (1978) · Physiology & Behavior · doi:10.1016/0031-9384(78)90198-1 · Cited by 18 · see citing works

Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation

Willner, P. (1997) · Psychopharmacology · doi:10.1007/s002130050456 · Cited by 1,832 · see citing works

Relationship between stress, eating behavior, and obesity

Torres, S. J., & Nowson, C. A. (2007) · Nutrition · doi:10.1016/j.nut.2007.08.008 · Cited by 1,622 · see citing works

Chronic Mild Stress (CMS) Revisited: Consistency and Behavioural-Neurobiological Concordance in the Effects of CMS

Willner, P. (2005) · Neuropsychobiology · doi:10.1159/000087097 · Cited by 1,605 · see citing works

Chronic mild stress-induced anhedonia: A realistic animal model of depression

Willner, P., Muscat, R., & Papp, M. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80194-0 · Cited by 1,160 · see citing works

Cytokines for psychologists: Implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition.

Maier, S. F., & Watkins, L. R. (1998) · Psychological Review · doi:10.1037/0033-295x.105.1.83 · Cited by 1,130 · see citing works

The chronic mild stress (CMS) model of depression: History, evaluation and usage

Willner, P. (2017) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.08.002 · Cited by 959 · see citing works

IL-1β is an essential mediator of the antineurogenic and anhedonic effects of stress

Koo, J. W., & Duman, R. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708092105 · Cited by 862 · see citing works

Chronic unpredictable mild stress for modeling depression in rodents: Meta-analysis of model reliability

Antoniuk, S., Bijata, M., Ponimaskin, E., & Wlodarczyk, J. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.12.002 · Cited by 750 · see citing works

Dopamine system dysregulation in major depressive disorders

Belujon, P., & Grace, A. A. (2017) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx056 · Cited by 754 · see citing works

Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects

Mahar, I., Bambico, F. R., Mechawar, N., & Nobrega, J. N. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.11.009 · Cited by 694 · see citing works

Assessing anhedonia in depression: potentials and pitfalls

Rizvi, S. J., Pizzagalli, D. A., Sproule, B. A., & Kennedy, S. H. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.03.004 · Cited by 571 · see citing works

An animal model of anhedonia: attenuation of sucrose consumption and place preference conditioning by chronic unpredictable mild stress

Papp, M., Willner, P., & Muscat, R. (1991) · Psychopharmacology · doi:10.1007/bf02244188 · Cited by 542 · see citing works

The neurobiology of depression and antidepressant action

Willner, P., Scheel-Krüger, J., & Belzung, C. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.007 · Cited by 519 · see citing works

Mapping anhedonia onto reinforcement learning: a behavioural meta-analysis

Huys, Q. J., Pizzagalli, D. A., Bogdan, R., & Dayan, P. (2013) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-3-12 · Cited by 480 · see citing works

Effects of unpredictable chronic mild stress on anxiety and depression-like behavior in mice

Mineur, Y. S., Belzung, C., & Crusio, W. E. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.07.029 · Cited by 459 · see citing works

Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis

Taliaz, D., Stall, N., Dar, D. E., & Zangen, A. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.67 · Cited by 454 · see citing works

Leptin: A potential novel antidepressant

Lu, X.-Y., Kim, C. S., Frazer, A., & Zhang, W. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508901103 · Cited by 446 · see citing works

VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants

Warner-Schmidt, J. L., & Duman, R. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610282104 · Cited by 438 · see citing works

Microglial NLRP3 inflammasome activation mediates IL-1β-related inflammation in prefrontal cortex of depressive rats

Pan, Y., Chen, X.-Y., Zhang, Q.-Y., & Kong, L.-D. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.04.007 · Cited by 405 · see citing works

Chronic Unpredictable Stress Induces a Cognitive Deficit and Anxiety-Like Behavior in Rats that is Prevented by Chronic Antidepressant Drug Treatment

Bondi, C. O., Rodriguez, G., Gould, G. G., Frazer, A., & Morilak, D. A. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301410 · Cited by 398 · see citing works

Motivational systems in adolescence: Possible implications for age differences in substance abuse and other risk-taking behaviors

Doremus-Fitzwater, T. L., Varlinskaya, E. I., & Spear, L. P. (2010) · Brain and Cognition · doi:10.1016/j.bandc.2009.08.008 · Cited by 397 · see citing works

Animal models of major depression and their clinical implications

Czéh, B., Fuchs, E., Wiborg, O., & Simon, M. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.04.004 · Cited by 375 · see citing works

The Flinders sensitive line rats: a genetic animal model of depression

Overstreet, D. H. (1993) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80230-1 · Cited by 369 · see citing works

Gender Differences in the Effects of Prenatal Stress on Brain Development and Behaviour

Weinstock, M. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9339-4 · Cited by 349 · see citing works

Antidepressant-like Activity of the Fatty Acid Amide Hydrolase Inhibitor URB597 in a Rat Model of Chronic Mild Stress

Bortolato, M., Mangieri, R. A., Fu, J., Kim, J. H., Arguello, O., Duranti, A., Tontini, A., Mor, M., Tarzia, G., & Piomelli, D. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.12.001 · Cited by 347 · see citing works

Stress-induced hyperalgesia

Jennings, E. M., Okine, B. N., Roche, M., & Finn, D. P. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.06.003 · Cited by 318 · see citing works

Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings

Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299 · see citing works

Behavioural and neurochemical effects induced by chronic mild stress applied to two different rat strains

Bekris, S., Antoniou, K., Daskas, S., & Papadopoulou-Daifoti, Z. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.01.005 · Cited by 281 · see citing works

Association between repeated unpredictable chronic mild stress (UCMS) procedures with a high fat diet: a model of fluoxetine resistance in mice

Isingrini, E., Camus, V., Le Guisquet, A.-M., Pingaud, M., Devers, S., & Belzung, C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010404 · Cited by 277 · see citing works

Antidepressant activity of non-competitive and competitive NMDA receptor antagonists in a chronic mild stress model of depression

Papp, M., & Moryl, E. (1994) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)90516-9 · Cited by 272 · see citing works

Gap Junction Dysfunction in the Prefrontal Cortex Induces Depressive-Like Behaviors in Rats

Sun, J.-D., Liu, Y., Yuan, Y.-H., Li, J., & Chen, N.-H. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.319 · Cited by 258 · see citing works

Stress and Loss of Adult Neurogenesis Differentially Reduce Hippocampal Volume

Schoenfeld, T. J., McCausland, H. C., Morris, H. D., Padmanaban, V., & Cameron, H. A. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.05.013 · Cited by 260 · see citing works

Depression and type 2 diabetes: Inflammatory mechanisms of a psychoneuroendocrine co-morbidity

Stuart, M. J., & Baune, B. T. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.10.001 · Cited by 257 · see citing works

Regional alterations in the endocannabinoid system in an animal model of depression: effects of concurrent antidepressant treatment

Hill, M. N., Carrier, E. J., McLaughlin, R. J., Morrish, A. C., Meier, S. E., Hillard, C. J., & Gorzalka, B. B. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05567.x · Cited by 246 · see citing works

Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression

Márquez, C., Poirier, G. L., Cordero, M. I., Larsen, M. H., Groner, A., Marquis, J., Magistretti, P. J., Trono, D., & Sandi, C. (2013) · Translational Psychiatry · doi:10.1038/tp.2012.144 · Cited by 245 · see citing works

Oxytocin protects against negative behavioral and autonomic consequences of long-term social isolation

Grippo, A. J., Trahanas, D. M., Zimmerman, R. R., Porges, S. W., & Carter, C. S. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.05.017 · Cited by 240 · see citing works

Reversal of stress-induced anhedonia by the atypical antidepressants, fluoxetine and maprotiline

Muscat, R., Papp, M., & Willner, P. (1992) · Psychopharmacology · doi:10.1007/bf02247719 · Cited by 237 · see citing works

Neuronal nitric oxide synthase contributes to chronic stress-induced depression by suppressing hippocampal neurogenesis

Zhou, Q., Hu, Y., Hua, Y., Hu, M., Luo, C., Han, X., Zhu, X., Wang, B., Xu, J., & Zhu, D. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04914.x · Cited by 225 · see citing works

Stress increases vulnerability to inflammation in the rat prefrontal cortex

de Pablos, R. M., Villarán, R. F., Argüelles, S., Herrera, A. J., Venero, J. L., Ayala, A., Cano, J., & Machado, A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0802-06.2006 · Cited by 215 · see citing works

Measuring behavior in mice with chronic stress depression paradigm

Strekalova, T., & Steinbusch, H. W. M. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.12.014 · Cited by 207 · see citing works

Behavioral effects of neuropeptides in rodent models of depression and anxiety

Rotzinger, S., Lovejoy, D. A., & Tan, L. A. (2010) · Peptides · doi:10.1016/j.peptides.2009.12.015 · Cited by 211 · see citing works

Beneficial effects of exercise and its molecular mechanisms on depression in rats.

Zheng, H., Liu, Y., Li, W., Yang, B., Chen, D., Wang, X., Jiang, Z., Wang, H., Wang, Z., Cornelisson, G., et al. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.10.007 · Cited by 212 · see citing works

Inoculation stress hypothesis of environmental enrichment.

Crofton, E. J., Zhang, Y., & Green, T. A. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.11.017 · Cited by 206 · see citing works

Decreased hedonic responsiveness following chronic mild stress is not secondary to loss of body weight

Willner, P., Moreau, J.-L., Kurre Nielsen, C., Papp, M., & Sluzewska, A. (1996) · Physiology & Behavior · doi:10.1016/0031-9384(95)02256-2 · Cited by 205 · see citing works

Chronic Stress Enhances Microglia Activation and Exacerbates Death of Nigral Dopaminergic Neurons under Conditions of Inflammation

de Pablos, R. M., Herrera, A. J., Espinosa-Oliva, A. M., Sarmiento, M., Muñoz, M. F., Machado, A., & Venero, J. L. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-34 · Cited by 201 · see citing works

Relationship of anhedonia and anxiety to social rank, defeat and entrapment

Gilbert, P., Allan, S., Brough, S., Melley, S., & Miles, J. N. V. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(01)00392-5 · Cited by 200 · see citing works

Reliability of the chronic mild stress model of depression: A user survey

Willner, P. (2017) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.08.001 · Cited by 198 · see citing works

Depression-like behavior and stressor-induced neuroendocrine activation in female prairie voles exposed to chronic social isolation

Grippo, A. J., Cushing, B. S., & Carter, C. S. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31802f054b · Cited by 196 · see citing works

Neuropathic pain promotes adaptive changes in gene expression in brain networks involved in stress and depression

Descalzi, G., Mitsi, V., Purushothaman, I., Gaspari, S., Avrampou, K., Loh, Y.-H. E., Shen, L., & Zachariou, V. (2017) · Science Signaling · doi:10.1126/scisignal.aaj1549 · Cited by 188 · see citing works

Inhibition of mitochondrial respiratory chain in brain of rats subjected to an experimental model of depression

Rezin, G. T., Cardoso, M. R., Gonçalves, C. L., Scaini, G., Fraga, D. B., Riegel, R. E., Comim, C. M., Quevedo, J., & Streck, E. L. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.09.012 · Cited by 197 · see citing works

Social isolation disrupts autonomic regulation of the heart and influences negative affective behaviors

Grippo, A. J., Lamb, D. G., Carter, C. S., & Porges, S. W. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.04.011 · Cited by 188 · see citing works

Local potentiation of excitatory synapses by serotonin and its alteration in rodent models of depression

Cai, X., Kallarackal, A. J., Kvarta, M. D., Goluskin, S., Gaylor, K., Bailey, A. M., Lee, H.-K., Huganir, R. L., & Thompson, S. M. (2013) · Nature Neuroscience · doi:10.1038/nn.3355 · Cited by 180 · see citing works

Impaired GABA synthesis, uptake and release are associated with depression-like behaviors induced by chronic mild stress

Ma, K., Xu, A., Cui, S., Sun, M.-R., Xue, Y.-C., & Wang, J.-H. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.181 · Cited by 168 · see citing works

Minocycline ameliorates depressive behaviors and neuro-immune dysfunction induced by chronic unpredictable mild stress in the rat

Zhang, C., Zhang, Y.-P., Li, Y.-Y., Liu, B.-P., Wang, H.-Y., Li, K.-W., Zhao, S., & Song, C. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.07.001 · Cited by 172 · see citing works

Food intake and reward mechanisms in patients with schizophrenia: implications for metabolic disturbances and treatment with second-generation antipsychotic agents

Elman, I., Borsook, D., & Lukas, S. E. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301051 · Cited by 169 · see citing works

Update in the methodology of the chronic stress paradigm: internal control matters

Strekalova, T., Couch, Y., Kholod, N., Boyks, M., Malin, D., Leprince, P., & Steinbusch, H. M. (2011) · Behavioral and Brain Functions · doi:10.1186/1744-9081-7-9 · Cited by 163 · see citing works

Chronic administration of fluoxetine and pro-inflammatory cytokine change in a rat model of depression

Lu, Y., Ho, C. S., Liu, X., Chua, A. N., Wang, W., McIntyre, R. S., & Ho, R. C. (2017) · PLOS ONE · doi:10.1371/journal.pone.0186700 · Cited by 164 · see citing works

Hippocampal MicroRNA-124 Enhances Chronic Stress Resilience in Mice

Higuchi, F., Uchida, S., Yamagata, H., Abe-Higuchi, N., Hobara, T., Hara, K., Kobayashi, A., Shintaku, T., Itoh, Y., Suzuki, T., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0319-16.2016 · Cited by 158 · see citing works

Involvement of hippocampal serotonin and neuropeptide Y in depression induced by chronic unpredicted mild stress

Luo, D. D., An, S. C., & Zhang, X. (2008) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2008.05.010 · Cited by 155 · see citing works

Oxytocin mitigated the depressive-like behaviors of maternal separation stress through modulating mitochondrial function and neuroinflammation

Amini-Khoei, H., Mohammadi-Asl, A., Amiri, S., Hosseini, M.-J., Momeny, M., Hassanipour, M., Rastegar, M., Haj-Mirzaian, A., Mirzaian, A. H., Sanjarimoghaddam, H., et al. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.02.022 · Cited by 153 · see citing works

Effects of curcumin on learning and memory deficits, BDNF, and ERK protein expression in rats exposed to chronic unpredictable stress

Liu, D., Wang, Z., Gao, Z., Xie, K., Zhang, Q., Jiang, H., & Pang, Q. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.05.068 · Cited by 151 · see citing works

Stress is critical for LPS-induced activation of microglia and damage in the rat hippocampus

Espinosa-Oliva, A. M., de Pablos, R. M., Villarán, R. F., Argüelles, S., Venero, J. L., Machado, A., & Cano, J. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.01.012 · Cited by 151 · see citing works

Chronic treatment with celecoxib reverses chronic unpredictable stress-induced depressive-like behavior via reducing cyclooxygenase-2 expression in rat brain

Guo, J.-Y., Li, C.-Y., Ruan, Y.-P., Sun, M., Qi, X.-L., Zhao, B.-S., & Luo, F. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.03.076 · Cited by 148 · see citing works

Ketamine Alleviates Depressive-Like Behaviors <i>via</i> Down-Regulating Inflammatory Cytokines Induced by Chronic Restraint Stress in Mice

Tan, S., Wang, Y., Chen, K., Long, Z., & Zou, J. (2017) · Biological & Pharmaceutical Bulletin · doi:10.1248/bpb.b17-00131 · Cited by 142 · see citing works

Neuropeptide and small transmitter coexistence: Fundamental studies and relevance to mental illness

Hökfelt, T., Barde, S., Xu, Z.-Q. D., Kuteeva, E., Rüegg, J., Le Maitre, E., Risling, M., Kehr, J., Ihnatko, R., Theodorsson, E., et al. (2018) · Frontiers in Neural Circuits · doi:10.3389/fncir.2018.00106 · Cited by 139 · see citing works

Translational assessment of reward and motivational deficits in psychiatric disorders

Der-Avakian, A., Barnes, S. A., Markou, A., & Pizzagalli, D. A. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_5004 · Cited by 122 · see citing works

Fluoxetine ameliorates dysbiosis in a depression model induced by chronic unpredicted mild stress in mice

Sun, L., Zhang, H., Cao, Y., Wang, C., Zhao, C., Wang, H., Cui, G., Wang, M., Pan, Y., Shi, Y., et al. (2019) · International Journal of Medical Sciences · doi:10.7150/ijms.37322 · Cited by 127 · see citing works

The N-methyl-d-aspartate receptor, synaptic plasticity, and depressive disorder

Petrie, R. X. A., Reid, I. C., & Stewart, C. A. (2000) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(00)00063-2 · Cited by 129 · see citing works

SIRT1 in forebrain excitatory neurons produces sexually dimorphic effects on depression-related behaviors and modulates neuronal excitability and synaptic transmission in the medial prefrontal cortex

Lei, Y., Wang, J., Wang, D., Li, C., Liu, B., Fang, X., You, J., Guo, M., & Lu, X.-Y. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0352-1 · Cited by 131 · see citing works

Rapid Antidepressant Action and Restoration of Excitatory Synaptic Strength After Chronic Stress by Negative Modulators of Alpha5-Containing GABAA Receptors

Fischell, J., Van Dyke, A. M., Kvarta, M. D., LeGates, T. A., & Thompson, S. M. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.112 · Cited by 122 · see citing works

Chronic variable stress and partial 5-HT denervation by parachloroamphetamine treatment in the rat: Effects on behavior and monoamine neurochemistry

Harro, J., Tõnissaar, M., Eller, M., Kask, A., & Oreland, L. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02256-9 · Cited by 124 · see citing works

Predictable chronic mild stress in adolescence increases resilience in adulthood

Suo, L., Zhao, L., Si, J., Liu, J., Zhu, W., Chai, B., Zhang, Y., Feng, J., Ding, Z., Luo, Y., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.67 · Cited by 122 · see citing works

Rapid antidepressant actions of scopolamine: Role of medial prefrontal cortex and M1-subtype muscarinic acetylcholine receptors

Navarria, A., Wohleb, E. S., Voleti, B., Ota, K. T., Dutheil, S., Lepack, A. E., Dwyer, J. M., Fuchikami, M., Becker, A., Drago, F., et al. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.06.012 · Cited by 118 · see citing works

Interleukin-17 induced by cumulative mild stress promoted depression-like behaviors in young adult mice

Kim, J., Suh, Y.-H., & Chang, K.-A. (2021) · Molecular Brain · doi:10.1186/s13041-020-00726-x · Cited by 116 · see citing works

Fecal transplant prevents gut dysbiosis and anxiety-like behaviour after spinal cord injury in rats

Schmidt, E. K. A., Torres-Espin, A., Raposo, P. J. F., Madsen, K. L., Kigerl, K. A., Popovich, P. G., Fenrich, K. K., & Fouad, K. (2020) · PLoS ONE · doi:10.1371/journal.pone.0226128 · Cited by 119 · see citing works

Selective deletion of the leptin receptor in dopamine neurons produces anxiogenic-like behavior and increases dopaminergic activity in amygdala

Liu, J., Perez, S. M., Zhang, W., Lodge, D. J., & Lu, X.-Y. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.36 · Cited by 118 · see citing works

Magnetic resonance imaging and spectroscopy reveal differential hippocampal changes in anhedonic and resilient subtypes of the chronic mild stress rat model

Delgado y Palacios, R., Campo, A., Henningsen, K., Verhoye, M., Poot, D., Dijkstra, J., Van Audekerke, J., Benveniste, H., Sijbers, J., Wiborg, O., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.05.014 · Cited by 113 · see citing works

Vaccination as a Novel Approach for Treating Depressive Behavior

Lewitus, G. M., Wilf-Yarkoni, A., Ziv, Y., Shabat-Simon, M., Gersner, R., Zangen, A., & Schwartz, M. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.07.014 · Cited by 109 · see citing works

HCN2 channels in the ventral tegmental area regulate behavioral responses to chronic stress

Zhong, P., Vickstrom, C. R., Liu, X., Hu, Y., Yu, L., Yu, H.-G., & Liu, Q.-S. (2018) · eLife · doi:10.7554/elife.32420 · Cited by 99 · see citing works

Extracellular Signal-Regulated Kinase-2 within the Ventral Tegmental Area Regulates Responses to Stress

Iñiguez, S. D., Vialou, V., Warren, B. L., Cao, J.-L., Alcantara, L. F., Davis, L. C., Manojlovic, Z., Neve, R. L., Russo, S. J., Han, M.-H., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0951-10.2010 · Cited by 103 · see citing works

Progress in understanding mood disorders: optogenetic dissection of neural circuits

Lammel, S., Tye, K. M., & Warden, M. R. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12049 · Cited by 98 · see citing works

Antidepressant-like effect of ginsenoside Rb1 on potentiating synaptic plasticity via the miR-134–mediated BDNF signaling pathway in a mouse model of chronic stress-induced depression

Wang, G., An, T., Lei, C., Zhu, X., Yang, L., Zhang, L., & Zhang, R. (2022) · Journal of Ginseng Research · doi:10.1016/j.jgr.2021.03.005 · Cited by 101 · see citing works

Ethanol‐induced conditioned taste aversion in male Sprague‐Dawley rats: impact of age and stress

Anderson, R. I., Varlinskaya, E. I., & Spear, L. P. (2010) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01307.x · Cited by 96 · see citing works

Increased corticotropin-releasing factor concentrations in the bed nucleus of the stria terminalis of anhedonic rats

Stout, S. C., Mortas, P., Owens, M. J., Nemeroff, C. B., & Moreau, J.-L. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00412-x · Cited by 94 · see citing works

Hedonic sensitivity in adolescent and adult rats: Taste reactivity and voluntary sucrose consumption

Wilmouth, C. E., & Spear, L. P. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.02.009 · Cited by 96 · see citing works

The role of ventral striatal cAMP signaling in stress-induced behaviors

Plattner, F., Hayashi, K., Hernández, A., Benavides, D. R., Tassin, T. C., Tan, C., Day, J., Fina, M. W., Yuen, E. Y., Yan, Z., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4066 · Cited by 94 · see citing works

Altered metabolic and neurochemical responses to chronic unpredictable stressors in ghrelin receptor-deficient mice

Patterson, Z. R., Ducharme, R., Anisman, H., & Abizaid, A. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07310.x · Cited by 95 · see citing works

Corticosterone mediates the synaptic and behavioral effects of chronic stress at rat hippocampal temporoammonic synapses

Kvarta, M. D., Bradbrook, K. E., Dantrassy, H. M., Bailey, A. M., & Thompson, S. M. (2015) · Journal of Neurophysiology · doi:10.1152/jn.00359.2015 · Cited by 86 · see citing works

Effects of Rhodiola rosea L. extract on behavioural and physiological alterations induced by chronic mild stress in female rats

Mattioli, L., Funari, C., & Perfumi, M. (2009) · Journal of Psychopharmacology · doi:10.1177/0269881108089872 · Cited by 91 · see citing works

Defining Valid Chronic Stress Models for Depression With Female Rodents

Lopez, J., & Bagot, R. C. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.03.010 · Cited by 86 · see citing works

Blockade of 2-arachidonoylglycerol hydrolysis produces antidepressant-like effects and enhances adult hippocampal neurogenesis and synaptic plasticity

Zhang, Z., Wang, W., Zhong, P., Liu, S. J., Long, J. Z., Zhao, L., Gao, H., Cravatt, B. F., & Liu, Q. (2015) · Hippocampus · doi:10.1002/hipo.22344 · Cited by 89 · see citing works

Bifidobacterium pseudocatenulatum CECT 7765 ameliorates neuroendocrine alterations associated with an exaggerated stress response and anhedonia in obese mice

Agusti, A., Moya-Pérez, A., Campillo, I., Montserrat-de la Paz, S., Cerrudo, V., Perez-Villalba, A., & Sanz, Y. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0768-z · Cited by 85 · see citing works

Blunted accumbal dopamine response to cocaine following chronic social stress in female rats: exploring a link between depression and drug abuse

Shimamoto, A., DeBold, J. F., Holly, E. N., & Miczek, K. A. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2364-7 · Cited by 81 · see citing works

Subsensitivity to rewarding and locomotor stimulant effects of a dopamine agonist following chronic mild stress

Papp, M., Muscat, R., & Willner, P. (1993) · Psychopharmacology · doi:10.1007/bf02246965 · Cited by 79 · see citing works

Ribosomal protein S6 kinase 1 signaling in prefrontal cortex controls depressive behavior

Dwyer, J. M., Maldonado-Avilés, J. G., Lepack, A. E., DiLeone, R. J., & Duman, R. S. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1505289112 · Cited by 76 · see citing works

Brain monoamine receptors in a chronic unpredictable stress model in rats

Ossowska, G., Nowak, G., Kata, R., Klenk-Majewska, B., Danilczuk, Z., & Żebrowska-Łupina, I. (2001) · Journal of Neural Transmission · doi:10.1007/s007020170077 · Cited by 76 · see citing works

Pathobiological targets of depression

Chopra, K., Kumar, B., & Kuhad, A. (2011) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2011.553603 · Cited by 76 · see citing works

Lipopolysaccharide-Induced Depressive-Like Behavior is Associated with α1-Adrenoceptor Dependent Downregulation of the Membrane GluR1 Subunit in the Mouse Medial Prefrontal Cortex and Ventral Tegmental Area

Sekio, M., & Seki, K. (2015) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu005 · Cited by 75 · see citing works

TLR4-NF-<i>κ</i>B Signal Involved in Depressive-Like Behaviors and Cytokine Expression of Frontal Cortex and Hippocampus in Stressed C57BL/6 and ob/ob Mice

Wang, Y., Xu, J., Liu, Y., Li, Z., & Li, X. (2018) · Neural Plasticity · doi:10.1155/2018/7254016 · Cited by 71 · see citing works

BDNF and COX-2 participate in anti-depressive mechanisms of catalpol in rats undergoing chronic unpredictable mild stress

Wang, J.-M., Yang, L.-H., Zhang, Y.-Y., Niu, C.-L., Cui, Y., Feng, W.-S., & Wang, G.-F. (2015) · Physiology &amp; Behavior · doi:10.1016/j.physbeh.2015.08.008 · Cited by 72 · see citing works

Depression-like behaviors induced by chronic corticosterone exposure via drinking water: Time-course analysis

Ding, H., Cui, X., Cui, S., Ye, H., Hu, X., Zhao, H., Liu, Y., & Zhang, Y. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.09.059 · Cited by 60 · see citing works

Attenuation of sucrose consumption in mice by chronic mild stress and its restoration by imipramine

Monleón, S., Parra, A., SIMON, V. M., Brain, P. F., D’Aquila, P. S., & Willner, P. (1995) · Psychopharmacology · doi:10.1007/bf02246218 · Cited by 233 · see citing works

Imipramine restores the long-term impairment of appetitive behavior in socially stressed rats

Frijtag, J. V., van den Bos, R., & Spruijt, B. M. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1093-3 · Cited by 81 · see citing works

Imipramine and tinnitus.

Tandon, R., Grunhaus, L. J., & Jf, G. (1987) · PubMed · Cited by 23 · see citing works

High-Affinity3H-lmipramine Binding: A new Biological Marker in Depression

Langer, S. Z., Zarifian, E., Briley, M., Raisman‐Vozari, R., & Sechter, D. (1982) · Pharmacopsychiatry · doi:10.1055/s-2007-1019502 · Cited by 50 · see citing works