Cited by 73Neurotransmitter Receptor Influence on BehaviorStress Responses and CortisolNeuroscience and Neuropharmacology Research

Operantly conditioned running: Effects on brain catecholamine concentrations and receptor densities in the rat

de Castro, John M., Duncan, Gary·1985·Pharmacology Biochemistry and Behavior

Abstract

It was hypothesized that endurance exercise results in an alteration in the brain monoamine systems. Rats were trained to run for food reinforcement on a variable ratio schedule in running wheels. Yoked control rats were also allowed to run but were not specifically reinforced for running. The animals ran 5 days per week for 8 weeks and were sacrificed 48 hours after the last endurance training session. The brains were assayed for norepinephrine and dopamine concentrations and beta-adrenergic (3H-dihydroalprenolol binding) and dopaminergic (3H-spiroperidol binding) receptor densities. Changes in norepinephrine concentration and beta-adrenergic receptor densities were not significantly different between reinforced running and yoked control groups. Dopamine concentrations were significantly higher while dopamine receptor densities were significantly lower in the reinforced running group. These results suggest that chronic running elevates dopamine secretion and consequently produces a compensatory down-regulation of dopaminergic receptor sites. The relationship of these changes to motor activity and to the antidepressant effects of exercise are discussed.

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Crossref · 10.1016/0091-3057(85)90407-1

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48 of 48 references verified0 citation errors · 0 not checkable

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  • Voluntary running exercises for 8 weeks significantly increased the levels of dopamine and its metabolites in the prefrontal cortex and striatum of rats.

    “Voluntary running exercises for 8 weeks significantly increased the levels of dopamine and its metabolites in the prefrontal cortex and striatum of rats [63].”

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Authors
de Castro, J. M., & Duncan, G.
Affiliations
Georgia State University (US)
Venue
Pharmacology Biochemistry and Behavior
Publisher
Elsevier BV
Published
1985-10
Volume
23
Issue
4
Pages
495-500
ISSN
0091-3057 (ISSN-L)
OpenAlex
W2064725886
Cited by
73
References
48
Citations by year
2026: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 4 · 2015: 2 · 2014: 3 · 2013: 5 · 2012: 3
FWCI
1.02
Type
journal article
Language
en
Open access
closed
Locations
  • Pharmacology Biochemistry and Behavior (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
operant conditioning, running wheel, endurance exercise, brain catecholamines, norepinephrine, dopamine, beta-adrenergic receptors, variable-ratio schedules, food reinforcement, antidepressant effects of exercise, monoaminergic systems
MeSH terms
Animals, Brain, Catecholamines, Conditioning, Operant, Dopamine, Male, Motor Activity, Norepinephrine, Receptors, Adrenergic, Receptors, Cholinergic, Receptors, Dopamine, Spiperone, Rats

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