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Cited by 128Neurotransmitter Receptor Influence on BehaviorNeuroendocrine regulation and behaviorNeuropeptides and Animal Physiology

Naloxone inhibits mating and conditioned place preference for an estrous female in male rats soon after castration

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Miller, R·1987·Pharmacology Biochemistry and Behavior
DOI 10.1016/0091-3057(87)90611-3
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Abstract

Three experiments were conducted to assess the role of endogenous opioids in controlling mating behavior and sexual reward in the male rat. In Experiment 1 SC administration of naloxone (0.5, 1.0, 5.0, or 10.0 mg/kg) significantly reduced mounting and ejaculation in male rats tested 14, but not 7 days, after castration. In Experiment 2 naloxone (5.0 mg/kg) administered SC to gonadally intact males, which had ejaculated repeatedly with one female until they were sexually sated, significantly inhibited the resumption of mating after the reintroduction of a female partner. One interpretation of these results is that naloxone attenuated the reward experienced by castrated and sexually sated males in the presence of an estrous female, thereby disrupting males' coital performance. This hypothesis was tested in Experiment 3 using a conditioned place preference paradigm in which males copulated with an estrous female in an initially "non-preferred" (white) compartment, whereas on alternate days they remained alone in an initially "preferred" (black) compartment. After 10 such conditioning sessions, males were either castrated or sham-operated. They later were given free access to both compartments in the absence of an estrous female. Seven days after conditioning and surgery, sham-operated, naloxone-injected males and both groups of castrates spent significantly less time than sham-operated, saline-injected controls in the initially "non-preferred" compartment. Fourteen days after conditioning and surgery castrated, naloxone-treated males spent significantly less time in the "non-preferred" compartment than males in the other three groups. Endogenous opioids may play an important role in the interpretation by males of the incentive motivational stimuli which emanate from an estrous female.

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  • When rats mate, they associate ejaculation reward with non-social cues and can form preferences for location or non-social odors.

    “Instead, when rats mate, they associate the reward from ejaculation with non-social cues and can form preferences for the location or for non-social odors (Miller and Baum 1987; Mehrara and Baum 1990; Ismail et al 2009).”

    From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Miller and Baum 1987

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Authors
Miller, R.
Affiliations
Boston University (US)
Corresponding author
Miller, R
Venue
Pharmacology Biochemistry and Behavior
Publisher
Elsevier BV
Published
1987-04
Volume
26
Issue
4
Pages
781-789
ISSN
0091-3057 (ISSN-L)
DOI
10.1016/0091-3057(87)90611-3
OpenAlex
W2064104252
Cited by
128
References
49
Citations by year
2024: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 2 · 2014: 5 · 2013: 3 · 2012: 6
FWCI
1.53
Type
journal article
Language
en
Open access
Licence
Locations
  • Pharmacology Biochemistry and Behavior (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • Harvard University
  • National Institute of Mental Health (MH-00392)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
naloxone, endogenous opioids, mating behavior, conditioned place preference, sexual reward, castration, estrous females, male rats, mounting, ejaculation, incentive motivation, opioid antagonism
MeSH terms
Animals, Conditioning, Psychological, Estrus, Female, Male, Naloxone, Orchiectomy, Reward, Sexual Behavior, Animal, Testis, Rats

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