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Cited by 112Neurotransmitter Receptor Influence on BehaviorNeuroendocrine regulation and behaviorNeuropeptides and Animal Physiology

Naloxone disrupts the expression but not the acquisition by male rats of a conditioned place preference response for an oestrous female

Mehrara, B. J., Baum, M. J.·1990·Psychopharmacology
DOI 10.1007/bf02253728
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Abstract

Two experiments were conducted to investigate the possible role of endogenous opioid peptides in the regulation of masculine sexual reward. In experiment 1 sexually experienced male rats, which had recently been castrated or left gonadally intact, were allowed to mate with an oestrous female in an initially "non-preferred" chamber of a test apparatus. On alternate days these males were placed alone in the initially "preferred" chamber of the same apparatus. After eight such conditioning sessions both intact and castrated males had acquired a conditioned place preference (CPP) for the initially "non-preferred" chamber whereas control males, which were never given access to an oestrous female, showed no evidence of a significant shift in their preference for either chamber. Administration of the opioid receptor antagonist, naloxone (1 or 5 mg/kg, SC) prior to each conditioning session had no significant influence on the acquisition of a CPP for an oestrous female. By contrast, in experiment 2 naloxone treatment significantly attenuated the expression of a previously established CPP for an oestrous female in both gonadally intact and castrated males. The results suggest that opioid components of neural reward circuits are normally activated in the male rat by conditioned incentive stimuli, but not by the primary rewarding stimuli associated with access to and mating with an oestrous female.

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  • When rats mate, they associate ejaculation reward with non-social cues and can form preferences for location or non-social odors.

    “Instead, when rats mate, they associate the reward from ejaculation with non-social cues and can form preferences for the location or for non-social odors (Miller and Baum 1987; Mehrara and Baum 1990; Ismail et al 2009).”

    From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Mehrara and Baum 1990

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Authors
Mehrara, B. J., & Baum, M. J.
Affiliations
Boston University (US)
ORCID
Venue
Psychopharmacology
Publisher
Springer Science and Business Media LLC
Published
1990-05
Volume
101
Issue
1
Pages
118-125
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
DOI
10.1007/bf02253728
OpenAlex
W2080791095
Cited by
112
References
32
Citations by year
2025: 1 · 2024: 1 · 2023: 3 · 2022: 2 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 1 · 2014: 4 · 2013: 3 · 2012: 6
FWCI
1.84
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Mental Health (MH-00392)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD21094, R01HD021094)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
naloxone, conditioned place preference, estrous females, endogenous opioids, opioid antagonism, castration, reward systems, mating behavior
MeSH terms
Animals, Behavior, Animal, Conditioning, Operant, Estrus, Female, Male, Naloxone, Rats

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