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Cited by 434

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Biased hypermutation and other genetic changes in defective measles viruses in human brain infections

Open access
Cattaneo, Roberto, Schmid, Anita, Eschle, Daniel, Baczko, Knut, ter Meulen, Volker, Billeter, Martin A.·1988·Cell
DOI 10.1016/0092-8674(88)90048-7
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Abstract

We assessed the alterations of viral gene expression occurring during persistent infections by cloning full-length transcripts of measles virus (MV) genes from brain autopsies of two subacute sclerosing panencephalitis patients and one measles inclusion body encephalitis (MIBE) patient. The suquence of these MV genes revealed that, most likely, almost 2% of the nucleotides were mutated during persistence, and 35% of these differences resulted in amino acid changes. One of these nucleotide substitutions and one deletion resulted in alteration of the reading frames of two fusion genes, as confirmed by in vitro translation of synthetic mRNAs. One cluster of mutations was exceptional; in the matrix gene of the MIBE case, 50% of the U residues were changed to C, which might result from a highly biased copying event exclusively affecting this gene. We propose that the cluster of mutations in the MIBE case, and other combinations of mutations in other cases, favored propagation of MV infections in brain cells by conferring a selective advantage to the mutated genomes.

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Metadata

Authors
Cattaneo, R., Schmid, A., Eschle, D., Baczko, K., ter Meulen, V., & Billeter, M. A.
Venue
Cell
Publisher
Elsevier BV
Published
1988-10
Volume
55
Issue
2
Pages
255-265
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/0092-8674(88)90048-7
OpenAlex
W2001949677
Cited by
434
References
30
FWCI
21.22
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Biased hypermutation and other genetic changes in defective measles viruses in human brain infections. https://app.cochat.ai/papers/10.1016/0092-8674(88)90048-7
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Cattaneo, R., Schmid, A., Eschle, D., Baczko, K., ter Meulen, V., & Billeter, M. A. (1988). Biased hypermutation and other genetic changes in defective measles viruses in human brain infections. Cell. https://doi.org/10.1016/0092-8674(88)90048-7

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