Antiviral Actions of Interferons

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080 · see citing works

NITRIC OXIDE AND MACROPHAGE FUNCTION

MacMicking, J. D., Xie, Q. W., & Nathan, C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.323 · Cited by 4,184 · see citing works

STATs and Gene Regulation

Darnell, J. E. (1997) · Science · doi:10.1126/science.277.5332.1630 · Cited by 3,979 · see citing works

HOW CELLS RESPOND TO INTERFERONS

Stark, G. R., Kerr, I. M., Williams, B. R. G., Silverman, R. H., & Schreiber, R. D. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.227 · Cited by 3,932 · see citing works

Interferon Alfa-2b Alone or in Combination with Ribavirin as Initial Treatment for Chronic Hepatitis C

McHutchison, J. G., Gordon, S. C., Schiff, E. R., Shiffman, M. L., Lee, W. M., Rustgi, V. K., Goodman, Z. D., Ling, M.-H., Cort, S., & Albrecht, J. K. (1998) · New England Journal of Medicine · doi:10.1056/nejm199811193392101 · Cited by 3,457 · see citing works

Virus interference. I. the interferon

Isaacs, A., & Lindenmann, J. (1957) · Proceedings of the Royal Society of London. Series B - Biological Sciences · doi:10.1098/rspb.1957.0048 · Cited by 3,451 · see citing works

CELLULAR RESPONSES TO INTERFERON-γ

Boehm, U., Klamp, T., Groot, M., & Howard, J. C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.749 · Cited by 2,890 · see citing works

Functional Role of Type I and Type II Interferons in Antiviral Defense

Müller, U., Steinhoff, U., Reis, L. F. L., Hemmi, S., Pavlovic, J., Zinkernagel, R. M., & Aguet, M. (1994) · Science · doi:10.1126/science.8009221 · Cited by 2,453 · see citing works

The Nature of the Principal Type 1 Interferon-Producing Cells in Human Blood

Siegal, F. P., Kadowaki, N., Shodell, M., Fitzgerald-Bocarsly, P. A., Shah, K., Ho, S., Antonenko, S., & Liu, Y.-J. (1999) · Science · doi:10.1126/science.284.5421.1835 · Cited by 2,293 · see citing works

Hepatitis C Viral Dynamics in Vivo and the Antiviral Efficacy of Interferon-α Therapy

Neumann, A. U., Lam, N. P., Dahari, H., Gretch, D. R., Wiley, T. E., Layden, T. J., & Perelson, A. S. (1998) · Science · doi:10.1126/science.282.5386.103 · Cited by 2,111 · see citing works

NATURAL KILLER CELLS IN ANTIVIRAL DEFENSE: Function and Regulation by Innate Cytokines

Biron, C. A., Nguyen, K. B., Pien, G. C., Cousens, L. P., & Salazar‐Mather, T. P. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.189 · Cited by 2,110 · see citing works

A family of cytokine-inducible inhibitors of signalling

Starr, R., Willson, T. A., Viney, E. M., Murray, L. J. L., Rayner, J. R., Jenkins, B. J., Gonda, T. J., Alexander, W. S., Metcalf, D., Nicola, N. A., et al. (1997) · Nature · doi:10.1038/43206 · Cited by 2,066 · see citing works

DNA Replication in Eukaryotic Cells

Bell, S. P., & Dutta, A. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135425 · Cited by 2,065 · see citing works

Jaks and STATs: biological implications.

Leonard, W., & O'Shea, J. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.293 · Cited by 1,939 · see citing works

INTERFERONS AND THEIR ACTIONS

Pestka, S., Langer, J. A., Zoon, K. C., & Samuel, C. E. (1987) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.56.070187.003455 · Cited by 1,826 · see citing works

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

Schindler, C., & Darnell, J. E. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.003201 · Cited by 1,808 · see citing works

Identification of genes differentially regulated by interferon α, β, or γ using oligonucleotide arrays

Der, S. D., Zhou, A., Williams, B. R. G., & Silverman, R. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15623 · Cited by 1,805 · see citing works

Acetylation of Histones and Transcription-Related Factors

Sterner, D. E., & Berger, S. L. (2000) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.64.2.435-459.2000 · Cited by 1,766 · see citing works

Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes

Dalton, D. K., Pitts-Meek, S., Keshav, S., Figari, I. S., Bradley, A., & Stewart, T. A. (1993) · Science · doi:10.1126/science.8456300 · Cited by 1,733 · see citing works

Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

Meraz, M. A., White, J. M., Sheehan, K. C. F., Bach, E. A., Rodig, S. J., Dighe, A. S., Kaplan, D. H., Riley, J. K., Greenlund, A. C., Campbell, D., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81288-x · Cited by 1,656 · see citing works

Immune Response in Mice that Lack the Interferon-γ Receptor

Huang, S., Hendriks, W. J. A. J., Althage, A., Hemmi, S., Bluethmann, H., Kamijo, R., Vilček, J., Zinkernagel, R. M., & Aguet, M. (1993) · Science · doi:10.1126/science.8456301 · Cited by 1,551 · see citing works

Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

Durbin, J. E., Hackenmiller, R., Simon, M. C., & Levy, D. E. (1996) · Cell · doi:10.1016/s0092-8674(00)81289-1 · Cited by 1,522 · see citing works

RNA editing in brain controls a determinant of ion flow in glutamate-gated channels

Sommer, B., Köhler, M., Sprengel, R., & Seeburg, P. H. (1991) · Cell · doi:10.1016/0092-8674(91)90568-j · Cited by 1,517 · see citing works

RNA VIRUS MUTATIONS AND FITNESS FOR SURVIVAL

Domingo, E., & Holland, J. J. (1997) · Annual Review of Microbiology · doi:10.1146/annurev.micro.51.1.151 · Cited by 1,514 · see citing works

Efficient Initiation of HCV RNA Replication in Cell Culture

Blight, K. J., Kolykhalov, A. A., & Rice, C. M. (2000) · Science · doi:10.1126/science.290.5498.1972 · Cited by 1,420 · see citing works

A new protein containing an SH2 domain that inhibits JAK kinases

Endo, T. A., Masuhara, M., Yokouchi, M., Suzuki, R., Sakamoto, H., Mitsui, K., Matsumoto, A., Tanimura, S., Ohtsubo, M., Misawa, H., et al. (1997) · Nature · doi:10.1038/43213 · Cited by 1,408 · see citing works

Nitric Oxide Synthases: Properties and Catalytic Mechanism

Griffith, O. W., & Stuehr, D. J. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.003423 · Cited by 1,311 · see citing works

Life, death, and the pursuit of apoptosis.Preprint

White, E. (1996) · Genes & Development · doi:10.1101/gad.10.1.1 · Cited by 1,300 · see citing works

Interferon Alfa-2b Alone or in Combination with Ribavirin for the Treatment of Relapse of Chronic Hepatitis C

Davis, G. L., Esteban, R., Rustgi, V. K., Hoefs, J. C., Gordon, S. C., TREPO, C. G., Shiffman, M. L., Zeuzem, S., Craxı̀, A., Ling, M.-H., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199811193392102 · Cited by 1,271 · see citing works

NF-κB: A lesson in family values

Thanos, D., & Maniatis, T. (1995) · Cell · doi:10.1016/0092-8674(95)90506-5 · Cited by 1,247 · see citing works

Viral Clearance Without Destruction of Infected Cells During Acute HBV Infection

Guidotti, L. G., Rochford, R., Chung, J., Shapiro, M., Purcell, R., & Chisari, F. V. (1999) · Science · doi:10.1126/science.284.5415.825 · Cited by 1,223 · see citing works

Identification of nitric oxide synthase as a protective locus against tuberculosis

MacMicking, J. D., North, R. J., LaCourse, R., Mudgett, J. S., Shah, S. K., & Nathan, C. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5243 · Cited by 1,180 · see citing works

Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors

Parganas, E., Wang, D., Stravopodis, D. J., Topham, D. J., Marine, J., Teglund, S., Vanin, E. F., Bodner, S. M., Colamonici, O. R., van Deursen, J. M., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81167-8 · Cited by 1,157 · see citing works

Mutation rates among RNA viruses

Drake, J. W., & Holland, J. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.13910 · Cited by 1,143 · see citing works

Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS

Goulder, P., Phillips, R. E., Colbert, R. A., McAdam, S. N., Ogg, G. S., Nowak, M. A., Giangrande, P. L. F., Luzzi, G. A., Morgana, B., Edwards, A., et al. (1997) · Nature Medicine · doi:10.1038/nm0297-212 · Cited by 1,115 · see citing works

Differential viral induction of distinct interferon‐α genes by positive feedback through interferon regulatory factor‐7

Marié, I., Durbin, J. E., & Levy, D. E. (1998) · The EMBO Journal · doi:10.1093/emboj/17.22.6660 · Cited by 1,049 · see citing works

THE IFNγ RECEPTOR:A Paradigm for Cytokine Receptor Signaling

Bach, E. A., Aguet, M., & Schreiber, R. D. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.563 · Cited by 1,033 · see citing works

Nitric oxide synthases: which, where, how, and why?

Michel, T. M., & Féron, O. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119750 · Cited by 1,018 · see citing works

Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

MEURS, E. F., Chong, K. L., GALABRU, J., Thomas, N. S. B., Kerr, I. M., Williams, B. R. G., & Hovanessian, A. G. (1990) · Cell · doi:10.1016/0092-8674(90)90374-n · Cited by 1,017 · see citing works

Regulation of serotonin-2C receptor G-protein coupling by RNA editing

Burns, C. M., Chu, H., Rueter, S. M., Hutchinson, L. K., Canton, H., Sanders-Bush, E., & Emeson, R. B. (1997) · Nature · doi:10.1038/387303a0 · Cited by 1,010 · see citing works

Influenza A Virus Lacking the NS1 Gene Replicates in Interferon-Deficient Systems

García‐Sastre, A., Egorov, A., Matassov, D., Brandt, S., Levy, D. E., Durbin, J. E., Palese, P., & Muster, T. (1998) · Virology · doi:10.1006/viro.1998.9508 · Cited by 1,000 · see citing works

Inducible nitric oxide synthase: what difference does it make?

Nathan, C. F. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119782 · Cited by 948 · see citing works

Regulation of MHC Class II Expression by Interferon-γ Mediated by the Transactivator Gene CIITA

Steimle, V., Siegrist, C.-A., Mottet, A., Lisowska-Grospierre, B., & Mach, B. (1994) · Science · doi:10.1126/science.8016643 · Cited by 898 · see citing works

Disruption of the Jak1 Gene Demonstrates Obligatory and Nonredundant Roles of the Jaks in Cytokine-Induced Biologic Responses

Rodig, S. J., Meraz‐Ríos, M. A., White, J. M., Lampe, P. A., Riley, J. K., Arthur, C. D., King, K. L., Sheehan, K. C. F., Li, Y., Pennica, D., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81166-6 · Cited by 857 · see citing works

Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF‐3 and CBP/p300

Yoneyama, M., Suhara, W., Fukuhara, Y., Fukuda, M., Nishida, E., & Fujita, T. (1998) · The EMBO Journal · doi:10.1093/emboj/17.4.1087 · Cited by 841 · see citing works

Evidence That Hepatitis C Virus Resistance to Interferon Is Mediated through Repression of the PKR Protein Kinase by the Nonstructural 5A Protein

Gale, M., Korth, M. J., Tang, N., Tan, S., Hopkins, D. A., Dever, T. E., Polyak, S. J., Gretch, D. R., & Katze, M. G. (1997) · Virology · doi:10.1006/viro.1997.8493 · Cited by 810 · see citing works

Inhibition of Viral Replication by Interferon-γ-Induced Nitric Oxide Synthase

Karupiah, G., Xie, Q. W., Buller, R. M. L., Nathan, C., Duarte, C. J., & MacMicking, J. D. (1993) · Science · doi:10.1126/science.7690156 · Cited by 810 · see citing works

pppA2'p5'A2'p5'A: an inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells.

Kerr, I. M., & Brown, R. E. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.1.256 · Cited by 794 · see citing works

Dengue: the risk to developed and developing countries.

Monath, T. P. C. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.7.2395 · Cited by 787 · see citing works

SOCS1 Is a Critical Inhibitor of Interferon γ Signaling and Prevents the Potentially Fatal Neonatal Actions of this Cytokine

Alexander, W. S., Starr, R., Fenner, J. E., Scott, C. L., Handman, E., Sprigg, N. S., Corbin, J. E., Cornish, A. L., Darwiche, R., Owczarek, C. M., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80047-1 · Cited by 762 · see citing works

The γ 1 34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1α to dephosphorylate the α subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase

He, B., Gross, M., & Roizman, B. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.3.843 · Cited by 755 · see citing works

Control of Kinetic Properties of AMPA Receptor Channels by Nuclear RNA Editing

Lomeli, H., Mosbacher, J., Melcher, T., Höger, T., Geiger, J. R. P., Kuner, T., Monyer, H., Higuchi, M., Bach, A., & Seeburg, P. H. (1994) · Science · doi:10.1126/science.7992055 · Cited by 746 · see citing works

Inhibition of the Interferon- Inducible Protein Kinase PKR by HCV E2 Protein

Taylor, D. R., Shi, S. T., Romano, P. R., Barber, G. N., & Lai, M. M. C. (1999) · Science · doi:10.1126/science.285.5424.107 · Cited by 732 · see citing works

An unwinding activity that covalently modifies its double-stranded RNA substrate

Bass, B., & Weintraub, H. (1988) · Cell · doi:10.1016/0092-8674(88)90253-x · Cited by 730 · see citing works

Virus Infection Induces the Assembly of Coordinately Activated Transcription Factors on the IFN-β Enhancer In Vivo

Wathelet, M. G., Lin, C. H., Parekh, B. S., Ronco, L. V., Howley, P. M., & Maniatis, T. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80051-9 · Cited by 730 · see citing works

Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development

Matsuyama, T., Kimura, T., Kitagawa, M., Pfeffer, K., Kawakami, T., Watanabe, N., Kündig, T. M., Amakawa, R., Kishihara, K., Wakeham, A., et al. (1993) · Cell · doi:10.1016/s0092-8674(05)80086-8 · Cited by 649 · see citing works

Regulation of apoptosis by viral gene products

Teodoro, J. G., & Branton, P. E. (1997) · Journal of Virology · doi:10.1128/jvi.71.3.1739-1746.1997 · Cited by 635 · see citing works

The interferon system. A bird's eye view of its biochemistry.

Sen, G. C., & Lengyel, P. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42719-6 · Cited by 633 · see citing works

Deficient signaling in mice devoid of double‐stranded RNA‐dependent protein kinase.

Yang, Y. L., Reis, L. F. L., Pavlovic, J., Aguzzi, A., Schäfer, R., Kumar, A., Williams, B. R. G., Aguet, M., & Weissmann, C. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00300.x · Cited by 632 · see citing works

Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activityPreprint

Ronco, L. V., Karpova, A. Y., Vidal, M., & Howley, P. M. (1998) · Genes & Development · doi:10.1101/gad.12.13.2061 · Cited by 631 · see citing works

ANTIGEN PROCESSING AND PRESENTATION BY THE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX

York, I. A., & Rock, K. L. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.369 · Cited by 618 · see citing works

Prevention of Vertebrate Neuronal Death by the crmA Gene

Gagliardini, V., Fernandez, P.-A., Lee, R. K. K., Drexler, H. C. A., Rotello, R. J., Fishman, M. C., & Yuan, J. (1994) · Science · doi:10.1126/science.8303301 · Cited by 612 · see citing works

Antiviral actions of interferon interferon-regulated cellular proteins and their surprisingly selective antiviral activities

Samuel, C. E. (1991) · Virology · doi:10.1016/0042-6822(91)90112-o · Cited by 608 · see citing works

Control of PKR Protein Kinase by Hepatitis C Virus Nonstructural 5A Protein: Molecular Mechanisms of Kinase Regulation

Gale, M., Blakely, C. M., Kwieciszewski, B., Tan, S., Dossett, M. L., Tang, N., Korth, M. J., Polyak, S. J., Gretch, D. R., & Katze, M. G. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.9.5208 · Cited by 606 · see citing works

The Double-Stranded RNA-Dependent Protein Kinase PKR: Structure and Function

Clemens, M. J., & Elia, A. (1997) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1997.17.503 · Cited by 605 · see citing works

Pillars Article: Virus Interference. I. The Interferon. Proc R Soc Lond B Biol Sci. 1957. 147: 258-267

Isaacs, A., & Lindenmann, J.-M. (2015) · The Journal of Immunology · doi:10.1093/jimmunol/195.5.1911 · Cited by 602 · see citing works

Negative Regulation of Cytokine Signaling Pathways

Yasukawa, H., Sasaki, A. T., & Yoshimura, A. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.143 · Cited by 596 · see citing works

When Two Strands Are Better Than One: The Mediators and Modulators of the Cellular Responses to Double-Stranded RNA

Jacobs, B. L., & Langland, J. (1996) · Virology · doi:10.1006/viro.1996.0259 · Cited by 586 · see citing works

Immune interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endothelial cells and dermal fibroblasts.

Collins, T., Korman, A. J., Wake, C. T., Boss, J. M., Kappes, D. J., Fiers, W. C., Ault, K. A., Gimbrone, M. A., Strominger, J. L., & Pober, J. S. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.15.4917 · Cited by 584 · see citing works

Expression and Regulation by Interferon of a Double-Stranded-RNA-Specific Adenosine Deaminase from Human Cells: Evidence for Two Forms of the Deaminase

Patterson, J. B., & Samuel, C. E. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.10.5376 · Cited by 578 · see citing works

Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.

Kumar, A., Haque, J., Lacoste, J., Hiscott, J. B., & Williams, B. R. G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.14.6288 · Cited by 568 · see citing works

Genetic Variation in HTLV-III/LAV Over Time in Patients with AIDS or at Risk for AIDS

Hahn, B. H., Shaw, G. M., Taylor, M. E., Redfield, R. R., Markham, P., Salahuddin, S. Z., Wong‐Staal, F., Gallo, R. C., Parks, E. S., & Parks, W. P. (1986) · Science · doi:10.1126/science.3012778 · Cited by 564 · see citing works

Interferon action and apoptosis are defective in mice devoid of 2′,5′‐oligoadenylate‐dependent RNase L

Zhou, A., Paranjape, J., Brown, T. L., Nie, H., Naik, S., Dong, B., Chang, A., Trapp, B., Fairchild, R., Colmenares, C., et al. (1997) · The EMBO Journal · doi:10.1093/emboj/16.21.6355 · Cited by 559 · see citing works

Requirement for MAP Kinase (ERK2) Activity in Interferon α- and Interferon β-Stimulated Gene Expression Through STAT Proteins

David, M., Petricoin, E., Benjamin, C. D., Pine, R. I., Weber, M. J., & Larner, A. C. (1995) · Science · doi:10.1126/science.7569900 · Cited by 543 · see citing works

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

Koromilas, A. E., Roy, S., Barber, G. N., Katze, M. G., & Sonenberg, N. (1992) · Science · doi:10.1126/science.1382315 · Cited by 532 · see citing works

Essential Role for the dsRNA-Dependent Protein Kinase PKR in Innate Immunity to Viral Infection

Balachandran, S., Roberts, P. C., Brown, L. E., Truong, H., Pattnaik, A. K., Archer, D. R., & Barber, G. N. (2000) · Immunity · doi:10.1016/s1074-7613(00)00014-5 · Cited by 527 · see citing works

A mammalian RNA editing enzyme

Melcher, T., Maas, S., Herb, A., Sprengel, R., SEEBURG, P. H., & Higuchi, M. (1996) · Nature · doi:10.1038/379460a0 · Cited by 526 · see citing works

Expression cloning of 2-5A-dependent RNAase: A uniquely regulated mediator of interferon action

Zhou, A. (1993) · Cell · doi:10.1016/0092-8674(93)90403-d · Cited by 518 · see citing works

Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA

Mühlethaler‐Mottet, A., Otten, L., Steimle, V., & Mach, B. (1997) · The EMBO Journal · doi:10.1093/emboj/16.10.2851 · Cited by 507 · see citing works

Phenotype of Mice and Macrophages Deficient in Both Phagocyte Oxidase and Inducible Nitric Oxide Synthase

Shiloh, M. U., MacMicking, J. D., Nicholson, S., Brause, J. E., Potter, S. H., Marino, M., Fang, F. C., Dinauer, M. C., & Nathan, C. (1999) · Immunity · doi:10.1016/s1074-7613(00)80004-7 · Cited by 504 · see citing works

Mx protein: Constitutive expression in 3T3 cells transformed with cloned Mx cDNA confers selective resistance to influenza virus

Staeheli, P., Haller, O., Boll, W., Lindenmann, J.-M., & Weissmann, C. (1986) · Cell · doi:10.1016/0092-8674(86)90493-9 · Cited by 488 · see citing works

Interactions between Double-Stranded RNA Regulators and the Protein Kinase DAI

Manche, L., Green, S. R., Schmedt, C., & Mathews, M. B. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.11.5238 · Cited by 484 · see citing works

STAT proteins and transcriptional responses to extracellular signals

Horvath, C. M. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01624-8 · Cited by 483 · see citing works

The growing family of interferon regulatory factors

Nguyen, H., Hiscott, J., & Pitha, P. M. (1997) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(97)00019-1 · Cited by 480 · see citing works

The Ebola virus VP35 protein functions as a type I IFN antagonist

Basler, C. F., Wang, X., Mühlberger, E., Volchkov, V. E., Paragas, J., Klenk, H., García‐Sastre, A., & Palese, P. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.220398297 · Cited by 477 · see citing works

PACT, a protein activator of the interferon‐induced protein kinase, PKR

Patel, R. C., & Sen, G. C. (1998) · The EMBO Journal · doi:10.1093/emboj/17.15.4379 · Cited by 457 · see citing works

Cellular gene expression altered by human cytomegalovirus: Global monitoring with oligonucleotide arrays

Zhu, H., Cong, J.-P., Mamtora, G., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14470 · Cited by 447 · see citing works

Molecular cloning of cDNA for double-stranded RNA adenosine deaminase, a candidate enzyme for nuclear RNA editing.

Kim, U., Wang, Y., Sanford, T., Zeng, Y., & Nishikura, K. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.24.11457 · Cited by 442 · see citing works

DNA Microarray Analysis of Chimpanzee Liver during Acute Resolving Hepatitis C Virus Infection

Bigger, C. B., Brasky, K. M., & Lanford, R. E. (2001) · Journal of Virology · doi:10.1128/jvi.75.15.7059-7066.2001 · Cited by 442 · see citing works

Biased hypermutation and other genetic changes in defective measles viruses in human brain infections

Cattaneo, R., Schmid, A., Eschle, D., et al. (1988) · Cell · doi:10.1016/0092-8674(88)90048-7 · Cited by 439 · see citing works

Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase.

MEURS, E. F., GALABRU, J., Barber, G. N., Katze, M. G., & Hovanessian, A. G. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.1.232 · Cited by 426 · see citing works

The V Protein of Simian Virus 5 Inhibits Interferon Signalling by Targeting STAT1 for Proteasome-Mediated Degradation

Didcock, L., Young, D. F., Goodbourn, S., & Randall, R. E. (1999) · Journal of Virology · doi:10.1128/jvi.73.12.9928-9933.1999 · Cited by 422 · see citing works

Double-Stranded RNA as a Template for Gene Silencing

Bass, B. (2000) · Cell · doi:10.1016/s0092-8674(02)71133-1 · Cited by 418 · see citing works

Apoptosis: an innate immune response to virus infection

Everett, H., & McFadden, G. (1999) · Trends in Microbiology · doi:10.1016/s0966-842x(99)01487-0 · Cited by 418 · see citing works

Cytotoxic T lymphocytes inhibit hepatitis B virus gene expression by a noncytolytic mechanism in transgenic mice.

Guidotti, L. G., Ando, K., Hobbs, M. V., Ishikawa, T., Runkel, L., Schreiber, R. D., & Chisari, F. V. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.3764 · Cited by 412 · see citing works

The Suppressor of Cytokine Signaling (SOCS) 1 and SOCS3 but Not SOCS2 Proteins Inhibit Interferon-mediated Antiviral and Antiproliferative Activities

Song, M. M., & Shuai, K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.52.35056 · Cited by 396 · see citing works

Adenovirus virus-associated RNA and translation control

Mathews, M. B., & Shenk, T. E. (1991) · Journal of Virology · doi:10.1128/jvi.65.11.5657-5662.1991 · Cited by 393 · see citing works

A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis

Der, S. D., Yang, Y.-L., Weissmann, C., & Williams, B. R. G. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.3279 · Cited by 389 · see citing works

Molecular Mechanisms of Interferon Resistance Mediated by Viral-Directed Inhibition of PKR, the Interferon-Induced Protein Kinase

Gale, M., & Katze, M. G. (1998) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(97)00165-4 · Cited by 388 · see citing works

Binding of the Influenza Virus NS1 Protein to Double-Stranded RNA Inhibits the Activation of the Protein Kinase That Phosphorylates the eIF-2 Translation Initiation Factor

LU, Y., Wambach, M., Katze, M. G., & Krug, R. M. (1995) · Virology · doi:10.1006/viro.1995.9937 · Cited by 387 · see citing works

Vaccinia Virus B18R Gene Encodes a Type I Interferon-binding Protein That Blocks Interferon α Transmembrane Signaling

Colamonici, O. R., Domanski, P. J., Sweitzer, S. M., Larner, A. C., & Buller, R. M. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.27.15974 · Cited by 385 · see citing works

Activation of the dsRNA‐dependent protein kinase, PKR, induces apoptosis through FADD‐mediated death signaling

Balachandran, S., Kim, C. N., Yeh, W., Mak, T., Bhalla, K., & Barber, G. (1998) · EMBO Journal · doi:10.1093/emboj/17.23.6888 · Cited by 385 · see citing works

The eIF-2 alpha protein kinases, regulators of translation in eukaryotes from yeasts to humans.

Samuel, C. E. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52994-x · Cited by 384 · see citing works

p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons

Goh, K. C., Haque, S. J., & Williams, B. R. G. (1999) · The EMBO Journal · doi:10.1093/emboj/18.20.5601 · Cited by 381 · see citing works

A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responses.

Hwang, S. Y., Hertzog, P. J., Holland, K. A., Sumarsono, S. H., Tymms, M. J., Hamilton, J. A., Whitty, G. A., Bertoncello, I., & Kola, I. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.24.11284 · Cited by 378 · see citing works

Adenovirus VAI RNA antagonizes the antiviral action of interferon by preventing activation of the interferon-induced eIF-2α kinase

Kitajewski, J., Schneider, R. J., Safer, B., et al. (1986) · Cell · doi:10.1016/0092-8674(86)90383-1 · Cited by 368 · see citing works

DNA replication in eukaryotic cells

(1997) · Choice Reviews Online · doi:10.5860/choice.34-3292 · Cited by 365 · see citing works

Interferon Action: RNA Cleavage Pattern of a (2′-5′)Oligoadenylate—Dependent Endonuclease

Floyd-Smith, G., Slattery, E., & Lengyel, P. (1981) · Science · doi:10.1126/science.6165080 · Cited by 362 · see citing works

Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors

van den Broek, M. F., Müller, U., Huang, S., Aguet, M., & Zinkernagel, R. M. (1995) · Journal of Virology · doi:10.1128/jvi.69.8.4792-4796.1995 · Cited by 362 · see citing works

Influenza Virus NS1 Protein Counteracts PKR-Mediated Inhibition of Replication

Bergmann, M., Garcia-Sastre, A., Carnero, E., Pehamberger, H., Wolff, K., Palese, P., & Muster, T. (2000) · Journal of Virology · doi:10.1128/jvi.74.13.6203-6206.2000 · Cited by 362 · see citing works

KSHV ORF K9 (vIRF) is an oncogene which inhibits the interferon signaling pathway

Gao, S., Boshoff, C., Jayachandra, S., Weiss, R. A., Chang, Y., & Moore, P. S. (1997) · Oncogene · doi:10.1038/sj.onc.1201571 · Cited by 356 · see citing works

Interferons and Other Cytokines

Hendrzak, J. A., & Brunda, M. J. (1997) · Humana Press eBooks · doi:10.1007/978-1-59259-717-8_13 · Cited by 356 · see citing works

Class II transactivator (CIITA) is sufficient for the inducible expression of major histocompatibility complex class II genes

Chang, C., Fontes, J., Peterlin, M., & Flavell, R. (1994) · Journal of Experimental Medicine · doi:10.1084/jem.180.4.1367 · Cited by 352 · see citing works

New Mouse Model for Dengue Virus Vaccine Testing

Johnson, A. J., & Roehrig, J. T. (1999) · Journal of Virology · doi:10.1128/jvi.73.1.783-786.1999 · Cited by 351 · see citing works

Recent human influenza A (H1N1) viruses are closely related genetically to strains isolated in 1950

Nakajima, K., Desselberger, U., & Palese, P. (1978) · Nature · doi:10.1038/274334a0 · Cited by 351 · see citing works

Interferon Regulatory Factor 3 and CREB-Binding Protein/p300 Are Subunits of Double-Stranded RNA-Activated Transcription Factor DRAF1

Weaver, B. K., Kumar, K. P., & Reich, N. C. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.3.1359 · Cited by 351 · see citing works

Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF‐1 and NF‐κB

Kumar, A., Yang, Y., Flati, V., Der, S., Kadereit, S., Deb, A., Haque, J., Reis, L. F. L., Weissmann, C., & Williams, B. R. G. (1997) · The EMBO Journal · doi:10.1093/emboj/16.2.406 · Cited by 350 · see citing works

RNA editing of hepatitis delta virus antigenome by dsRNA-adenosine deaminase

Poison, A. G., Bass, B., & Casey, J. L. (1996) · Nature · doi:10.1038/380454a0 · Cited by 346 · see citing works

Biologic consequences of Stat1-independent IFN signaling

Gil, M. P., Bohn, E., O'Guin, A. K., Ramana, C. V., Levine, B., Stark, G. R., Virgin, H. W., & Schreiber, R. D. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111163898 · Cited by 345 · see citing works

Human RNA-specific adenosine deaminase ADAR1 transcripts possess alternative exon 1 structures that initiate from different promoters, one constitutively active and the other interferon inducible

George, C. X., & Samuel, C. E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.8.4621 · Cited by 343 · see citing works

Differential Regulation of the Alpha/Beta Interferon-Stimulated Jak/Stat Pathway by the SH2 Domain-Containing Tyrosine Phosphatase SHPTP1

David, M., Chen, H. E., Goelz, S. E., Larner, A. C., & Neel, B. G. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.12.7050 · Cited by 342 · see citing works

A double-stranded RNA unwinding activity introduces structural alterations by means of adenosine to inosine conversions in mammalian cells and Xenopus eggs.

Wagner, R. W., Smith, J. E., Cooperman, B. S., & Nishikura, K. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.8.2647 · Cited by 341 · see citing works

Role of early cytokines, including alpha and beta interferons (IFN-α\β), in innate and adaptive immune responses to viral infections

Biron, C. A. (1998) · Seminars in Immunology · doi:10.1006/smim.1998.0138 · Cited by 341 · see citing works

A Viral Mechanism for Inhibition of p300 and PCAF Acetyltransferase Activity

Chakravarti, D., Ogryzko, V., Kao, H.-Y., Nash, A., Chen, H., Nakatani, Y., & Evans, R. M. (1999) · Cell · doi:10.1016/s0092-8674(00)80552-8 · Cited by 339 · see citing works

Human Cytomegalovirus Inhibits Major Histocompatibility Complex Class II Expression By Disruption of the Jak/Stat Pathway

Miller, D. M., Rahill, B. M., Boss, J. M., Lairmore, M. D., Durbin, J. E., Waldman, J., & Sedmak, D. D. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.5.675 · Cited by 337 · see citing works

Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant.

Weiner, A. J., Erickson, A. L., Kansopon, J., Crawford, K., Muchmore, E., Hughes, A. L., Houghton, M., & Walker, C. M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.7.2755 · Cited by 334 · see citing works

The role of gamma interferon in antimicrobial immunity

Shtrichman, R., & Samuel, C. E. (2001) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(00)00199-5 · Cited by 334 · see citing works

Viruses and apoptosis

Shen, Y., & Shenk, T. E. (1995) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(95)90061-6 · Cited by 326 · see citing works

Modulation of Dengue Virus Infection in Human Cells by Alpha, Beta, and Gamma Interferons

Diamond, M., Roberts, T. G., Edgil, D., Lu, B., Ernst, J., & Harris, E. (2000) · Journal of Virology · doi:10.1128/jvi.74.11.4957-4966.2000 · Cited by 325 · see citing works

ESCAPE OF HUMAN IMMUNODEFICIENCY VIRUS FROM IMMUNE CONTROL

McMichael, A. J., & Phillips, R. E. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.271 · Cited by 323 · see citing works

Antisense RNA injections in fertilized frog eggs reveal an RNA duplex unwinding activity

Rebagliati, M. R., & Melton, D. A. (1987) · Cell · doi:10.1016/0092-8674(87)90238-8 · Cited by 321 · see citing works

Interferon action—sequence specificity of the ppp(A2′p)nA-dependent ribonuclease

Wreschner, D. H., McCauley, J. W., Skehel, J. J., & Kerr, I. M. (1981) · Nature · doi:10.1038/289414a0 · Cited by 321 · see citing works

Human p68 kinase exhibits growth suppression in yeast and homology to the translational regulator GCN2.

Chong, K. L., Feng, L., Schappert, K. T., MEURS, E. F., Donahue, T. F., Friesen, J. D., Hovanessian, A. G., & Williams, B. R. G. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05200.x · Cited by 320 · see citing works

Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: Induction of interferon-responsive RNAs

Zhu, H., Cong, J., & Shenk, T. E. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.13985 · Cited by 318 · see citing works

Translational Control of Viral Gene Expression in Eukaryotes

Gale, M., Tan, S., & Katze, M. G. (2000) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.64.2.239-280.2000 · Cited by 316 · see citing works

cDNA Structures and Regulation of Two Interferon-Induced Human Mx Proteins

Aebi, M., Fäh, J., Hurt, N., Samuel, C., Thomis, D. C., Bazzigher, L., Pavlovic, J., Haller, O., & Staeheli, P. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.11.5062 · Cited by 305 · see citing works

Interferon α/β-mediated inhibition and promotion of interferon γ: STAT1 resolves a paradox

Nguyen, K. B., Cousens, L. P., Doughty, L., Pien, G. C., Durbin, J. E., & Biron, C. A. (2000) · Nature Immunology · doi:10.1038/76940 · Cited by 303 · see citing works

Autophosphorylation of the protein kinase dependent on double-stranded RNA.

GALABRU, J., & Hovanessian, A. G. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47759-9 · Cited by 303 · see citing works

An Interferon-γ-activated Site (GAS) Is Necessary for Full Expression of the Mouse iNOS Gene in Response to Interferon-γ and Lipopolysaccharide

Gao, J., Morrison, D. C., Parmely, T. J., Russell, S. W., & Murphy, W. J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.2.1226 · Cited by 303 · see citing works

The Jak-STAT pathway: cytokine signalling from the receptor to the nucleus.

Heim, M. (1999) · Journal of Receptor and Signal Transduction Research · doi:10.3109/10799899909036638 · Cited by 300 · see citing works

THE MOLECULAR BIOLOGY OF HEPATITIS DELTA VIRUS

Lai, M. M. C. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.001355 · Cited by 298 · see citing works

Human and mouse Mx proteins inhibit different steps of the influenza virus multiplication cycle

Pavlovic, J., Haller, O., & Staeheli, P. (1992) · Journal of Virology · doi:10.1128/jvi.66.4.2564-2569.1992 · Cited by 297 · see citing works

Abrogation of translation initiation factor eIF‐2 phosphorylation causes malignant transformation of NIH 3T3 cells.

Donzé, O., Jagus, R., Koromilas, A. E., Hershey, J. W. B., & Sonenberg, N. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00052.x · Cited by 288 · see citing works

Expression of Hepatitis C Virus Proteins Inhibits Signal Transduction through the Jak-STAT Pathway

Heim, M. H., Moradpour, D., & Blum, H. E. (1999) · Journal of Virology · doi:10.1128/jvi.73.10.8469-8475.1999 · Cited by 287 · see citing works

The Role of Interferon in Influenza Virus Tissue Tropism

García‐Sastre, A., Durbin, R. K., Zheng, H., Palese, P., Gertner, R., Levy, D. E., & Durbin, J. E. (1998) · Journal of Virology · doi:10.1128/jvi.72.11.8550-8558.1998 · Cited by 286 · see citing works

Mx proteins: mediators of innate resistance to RNA viruses

Haller, O., Frese, M., & Kochs, G. (1998) · Scientific and Technical Review (World Organisation for Animal Health) · doi:10.20506/rst.17.1.1084 · Cited by 286 · see citing works

Microarray Analysis Identifies Interferon-Inducible Genes and Stat-1 as Major Transcriptional Targets of Human Papillomavirus Type 31

Chang, Y. E., & Laimins, L. A. (2000) · Journal of Virology · doi:10.1128/jvi.74.9.4174-4182.2000 · Cited by 284 · see citing works

Control of immune pathology by regulatory T cells

Mason, D., & Powrie, F. M. (1998) · Current Opinion in Immunology · doi:10.1016/s0952-7915(98)80084-8 · Cited by 278 · see citing works

IRF-7, a new interferon regulatory factor associated with Epstein-Barr virus latency

Zhang, L.-W., & Pagano, J. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.10.5748 · Cited by 277 · see citing works

The Vaccinia Virus Soluble Alpha/Beta Interferon (IFN) Receptor Binds to the Cell Surface and Protects Cells from the Antiviral Effects of IFN

Alcamı́, A., Symons, J. A., & Smith, G. L. (2000) · Journal of Virology · doi:10.1128/jvi.74.23.11230-11239.2000 · Cited by 274 · see citing works

Constitutive expression of (2′–5′) oligo A synthetase confers resistance to picornavirus infection

Chebath, J., Benech, P. D., Revel, M., & Vigneron, M. (1987) · Nature · doi:10.1038/330587a0 · Cited by 273 · see citing works

Regulation of Type I Interferon Gene Expression by Interferon Regulatory Factor-3

Schafer, S. L., Lin, R., Moore, P. A., Hiscott, J. B., & Pitha, P. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.5.2714 · Cited by 272 · see citing works

A dominant negative mutant of 2‐5A‐dependent RNase suppresses antiproliferative and antiviral effects of interferon.

Hassel, B. A., Zhou, A., Sotomayor, C. E., et al. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05999.x · Cited by 271 · see citing works

RNA editing of brain glutamate receptor channels: mechanism and physiology1Published on the World Wide Web on 5 February 1998.1

Seeburg, P. H., Higuchi, M., & Sprengel, R. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00062-3 · Cited by 269 · see citing works

Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma

Deyoung, K. L., Ray, M. E., Su, Y. A., Anzick, S. L., Johnstone, R. W., Trapani, J. A., Meltzer, P. S., & Trent, J. M. (1997) · Oncogene · doi:10.1038/sj.onc.1201206 · Cited by 268 · see citing works

Cloning of cDNAs encoding mammalian double-stranded RNA-specific adenosine deaminase

O’Connell, M. A., Krause, S., Higuchi, M., Hsuan, J. J., Totty, N. F., Jenny, A., & Keller, W. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.3.1389 · Cited by 268 · see citing works

Mechanism of interferon action: Phosphorylation of protein synthesis initiation factor eIF-2 in interferon-treated human cells by a ribosome-associated kinase processing site specificity similar to hemin-regulated rabbit reticulocyte kinase

Samuel, C. E. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.2.600 · Cited by 265 · see citing works

The 2–5 A system: Modulation of viral and cellular processes through acceleration of RNA degradation

Player, M. R., & Torrence, P. F. (1998) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(97)00167-8 · Cited by 264 · see citing works

2-5A-dependent RNase Molecules Dimerize during Activation by 2-5A

Dong, B., & Silverman, R. H. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.8.4133 · Cited by 261 · see citing works

Functional diversity in the dynamin family

van der Bliek, A. M., & van der Bliek, A. M. (1999) · Trends in Cell Biology · doi:10.1016/s0962-8924(98)01490-1 · Cited by 259 · see citing works

STAT3 as an Adapter to Couple Phosphatidylinositol 3-Kinase to the IFNAR1 Chain of the Type I Interferon Receptor

Pfeffer, L. M., Mullersman, J. E., Pfeffer, S. R., Murti, A., Shi, W., & Yang, C. H. (1997) · Science · doi:10.1126/science.276.5317.1418 · Cited by 258 · see citing works

Interferon-γ-Mediated Site-Specific Clearance of Alphavirus from CNS Neurons

Binder, G. K., & Griffin, D. E. (2001) · Science · doi:10.1126/science.1059742 · Cited by 252 · see citing works

The Type I Interferon Receptor: Structure, Function, and Evolution of a Family Business

Mogensen, K. E., Lewerenz, M., Reboul, J., Lutfalla, G., & Uzé, G. (1999) · Journal of Interferon & Cytokine Research · doi:10.1089/107999099313019 · Cited by 252 · see citing works

Antiapoptotic and Oncogenic Potentials of Hepatitis C Virus Are Linked to Interferon Resistance by Viral Repression of the PKR Protein Kinase

Gale, M., Kwieciszewski, B., Dossett, M. L., et al. (1999) · Journal of Virology · doi:10.1128/jvi.73.8.6506-6516.1999 · Cited by 251 · see citing works

Cloning and Characterization of a RNase L Inhibitor.

Bisbal, C., Martinand, C., Silhol, M., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.13308 · Cited by 248 · see citing works

Two RNA-binding motifs in the double-stranded RNA-activated protein kinase, DAI.Preprint

Green, S. R., & Mathews, M. B. (1992) · Genes & Development · doi:10.1101/gad.6.12b.2478 · Cited by 247 · see citing works

Triggering the Interferon Response: The Role of IRF-3 Transcription Factor

Hiscott, J. B., Pitha, P. M., Génin, P., Nguyen, H., Heylbroeck, C., Mamane, Y., Algarté-Génin, M., & Lin, R. (1999) · Journal of Interferon & Cytokine Research · doi:10.1089/107999099314360 · Cited by 246 · see citing works

Interferon Action in Triply Deficient Mice Reveals the Existence of Alternative Antiviral Pathways

Zhou, A., Paranjape, J. M., Der, S. D., Williams, B. R. G., & Silverman, R. H. (1999) · Virology · doi:10.1006/viro.1999.9738 · Cited by 244 · see citing works

Stat1-independent regulation of gene expression in response to IFN-γ

Ramana, C. V., Gil, M. P., Han, Y., Ransohoff, R. M., Schreiber, R. D., & Stark, G. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111164198 · Cited by 244 · see citing works

Alpha/Beta Interferon Protects Adult Mice from Fatal Sindbis Virus Infection and Is an Important Determinant of Cell and Tissue Tropism

Ryman, K. D., Klimstra, W. B., Nguyen, K. B., et al. (2000) · Journal of Virology · doi:10.1128/jvi.74.7.3366-3378.2000 · Cited by 244 · see citing works

Critical role of a common transcription factor, IRF‐1, in the regulation of IFN‐beta and IFN‐inducible genes.

Reis, L. F. L., Harada, H., Wolchok, J. D., Taniguchi, T., & Vilček, J. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05041.x · Cited by 243 · see citing works

Constitutive expression of human double-stranded RNA-activated p68 kinase in murine cells mediates phosphorylation of eukaryotic initiation factor 2 and partial resistance to encephalomyocarditis virus growth

MEURS, E. F., Watanabe, Y., Kadereit, S., et al. (1992) · Journal of Virology · doi:10.1128/jvi.66.10.5805-5814.1992 · Cited by 241 · see citing works

Four different forms of interferon-induced 2',5'-oligo(A) synthetase identified by immunoblotting in human cells.

Chebath, J., Benech, P. D., Hovanessian, A. G., GALABRU, J., & Revel, M. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61434-6 · Cited by 234 · see citing works

NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signaling

Tan, S., Nakao, H., He, Y., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5533 · Cited by 233 · see citing works

Essential and non‐redundant roles of p48 (ISGF3γ) and IRF‐1 in both type I and type II interferon responses, as revealed by gene targeting studies

Kimura, T., Kadokawa, Y., Harada, H., Matsumoto, M., Sato, M., Kashiwazaki, Y., Tarutani, M., Tan, R. S., Takasugi, T., Matsuyama, T., et al. (1996) · Genes to Cells · doi:10.1046/j.1365-2443.1996.08008.x · Cited by 233 · see citing works

A standardized nomenclature for adenosine deaminases that act on RNA

Bass, B., Nishikura, K., Keller, W. D., et al. (1997) · PubMed · doi:10.5451/unibas-ep2489 · Cited by 232 · see citing works

The Human 2',5'-Oligoadenylate Synthetase Family: Interferon-Induced Proteins with Unique Enzymatic Properties

Rebouillat, D., & Hovanessian, A. G. (1999) · Journal of Interferon & Cytokine Research · doi:10.1089/107999099313992 · Cited by 232 · see citing works

Characterization of Transgenic Mice with Targeted Disruption of the Catalytic Domain of the Double-stranded RNA-dependent Protein Kinase, PKR

Abraham, N. B., Stojdl, D. F., Duncan, P. I., Méthot, N., Ishii, T. M., Dubé, M., Vanderhyden, B. C., Atkins, H. L., Gray, D. A., McBurney, M. W., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.9.5953 · Cited by 231 · see citing works

Specific phenotypic restoration of an attenuated virus by knockout of a host resistance gene

Leib, D. A., Machalek, M. A., Williams, B. R. G., Silverman, R. H., & Virgin, H. W. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.100415697 · Cited by 230 · see citing works

PKR: a new name and new roles

Proud, C. G. (1995) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)89025-8 · Cited by 227 · see citing works

Minor-Groove Recognition of Double-Stranded RNA by the Double-Stranded RNA-Binding Domain from the RNA-Activated Protein Kinase PKR

Bevilacqua, P. C., & Cech, T. R. (1996) · Biochemistry · doi:10.1021/bi9607259 · Cited by 227 · see citing works

Crystal structure of an IRF‐DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequences

Fujii, Y., Shimizu, T., Kusumoto, M., Kyogoku, Y., Taniguchi, T., & Hakoshima, T. (1999) · The EMBO Journal · doi:10.1093/emboj/18.18.5028 · Cited by 223 · see citing works

Inhibition of PKR Activation by the Proline-Rich RNA Binding Domain of the Herpes Simplex Virus Type 1 Us11 Protein

Poppers, J., Mulvey, M. A., Khoo, D., & Mohr, I. (2000) · Journal of Virology · doi:10.1128/jvi.74.23.11215-11221.2000 · Cited by 223 · see citing works

Oncogenic potential of TAR RNA binding protein TRBP and its regulatory interaction with RNA‐dependent protein kinase PKR

Benkirane, M., Neuveut, C., Chun, R. F., Smith, S. M., Samuel, C. E., Gatignol, A., & Jeang, K. (1997) · The EMBO Journal · doi:10.1093/emboj/16.3.611 · Cited by 221 · see citing works

Ser727‐dependent recruitment of MCM5 by Stat1α in IFN‐γ‐induced transcriptional activation

Zhang, J. J., Zhao, Y., Chait, B. T., Lathem, W. W., Ritzi, M., Knippers, R., & Darnell, J. E., Jr. (1998) · The EMBO Journal · doi:10.1093/emboj/17.23.6963 · Cited by 221 · see citing works

Regulated Nuclear-Cytoplasmic Localization of Interferon Regulatory Factor 3, a Subunit of Double-Stranded RNA-Activated Factor 1

Kumar, K. P., McBride, K. M., Weaver, B. K., Dingwall, C., & Reich, N. C. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.4159-4168.2000 · Cited by 209 · see citing works

A new pathway of translational regulation mediated by eukaryotic initiation factor 3

Guo, J., Hui, D. J., Merrick, W. C., & Sen, G. C. (2000) · The EMBO Journal · doi:10.1093/emboj/19.24.6891 · Cited by 206 · see citing works

Sendai Virus C Proteins Counteract the Interferon-Mediated Induction of an Antiviral State

Garcin, D., Latorre, P., & Kolakofsky, D. (1999) · Journal of Virology · doi:10.1128/jvi.73.8.6559-6565.1999 · Cited by 204 · see citing works

Forced degradation of Fas inhibits apoptosis in adenovirus-infected cells

Tollefson, A. E., Hermiston, T. W., Lichtenstein, D. L., Colle, C. F., Tripp, R. A., Dimitrov, T., Tóth, K., Wells, C. E., Doherty, P. C., & Wold, W. S. M. (1998) · Nature · doi:10.1038/33712 · Cited by 203 · see citing works

Functional expression and RNA binding analysis of the interferon-induced, double-stranded RNA-activated, 68,000-Mr protein kinase in a cell-free system.

Katze, M. G., Wambach, M., Wong, M., Garfinkel, M. S., MEURS, E. F., Chong, K. L., Williams, B. R. G., Hovanessian, A. G., & Barber, G. N. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.11.5497 · Cited by 203 · see citing works

Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-γ target genes

Ouchi, T., Lee, S. W., Ouchi, M., Aaronson, S. A., & Horvath, C. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.080469697 · Cited by 202 · see citing works

Viral cross talk: intracellular inactivation of the hepatitis B virus during an unrelated viral infection of the liver.

Guidotti, L. G., Borrow, P., Hobbs, M. V., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4589 · Cited by 202 · see citing works

Tumor-suppressor genes: news about the interferon connection.

Lengyel, P. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.13.5893 · Cited by 199 · see citing works

Induction of Apoptosis by Double-Stranded-RNA-Dependent Protein Kinase (PKR) Involves the α Subunit of Eukaryotic Translation Initiation Factor 2 and NF-κB

Gil, J., Alcamí, J., & Esteban, M. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.7.4653 · Cited by 199 · see citing works

Nuclear antisense RNA induces extensive adenosine modifications and nuclear retention of target transcripts

Kumar, M., & Carmichael, G. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.3542 · Cited by 198 · see citing works

Paramyxoviridae Use Distinct Virus-Specific Mechanisms to Circumvent the Interferon Response

Young, D. F., Didcock, L., Goodbourn, S., & Randall, R. E. (2000) · Virology · doi:10.1006/viro.2000.0240 · Cited by 196 · see citing works

The Murine Double-Stranded RNA-Dependent Protein Kinase PKR Is Required for Resistance to Vesicular Stomatitis Virus

Stojdl, D. F., Abraham, N. B., Knowles, S., Marius, R. M., Brasey, A., Lichty, B. D., Brown, E. G., Sonenberg, N., & Bell, J. C. (2000) · Journal of Virology · doi:10.1128/jvi.74.20.9580-9585.2000 · Cited by 196 · see citing works

Structure of two forms of the interferon‐induced (2′‐5′) oligo A synthetase of human cells based on cDNAs and gene sequences.

Benech, P. D., Mory, Y. Y., Revel, M., & Chebath, J. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb03922.x · Cited by 195 · see citing works

Interferon-induced human MxA GTPase blocks nuclear import of Thogoto virus nucleocapsids

Kochs, G., & Haller, O. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2082 · Cited by 195 · see citing works

The Biologic Activity and Molecular Characterization of a Novel Synthetic Interferon-Alpha Species, Consensus Interferon

Blatt, L. M., Davis, J. M., KLEIN, S. B., & Taylor, M. W. (1996) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1996.16.489 · Cited by 192 · see citing works

Viruses and interferon: a fight for supremacy

Katze, M. G., He, Y., & Gale, M. (2002) · Nature Reviews Immunology · doi:10.1038/nri888 · Cited by 1,419 · see citing works

Evasion of Type I Interferon by SARS-CoV-2

Xia, H., Cao, Z., Xie, X., Zhang, X., Chen, J. Y.-C., Wang, H., Menachery, V. D., Rajsbaum, R., & Shi, P.-Y. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108234 · Cited by 957 · see citing works

The airway epithelium: soldier in the fight against respiratory viruses

Vareille, M., Kieninger, E., Edwards, M. R., & Regamey, N. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-10 · Cited by 655 · see citing works

RIG-I detects viral genomic RNA during negative-strand RNA virus infection

Rehwinkel, J., Tan, C. P., Goubau, D., Schulz, O., Pichlmair, A., Bier, K., Robb, N., Vreede, F., Barclay, W., Fodor, E., et al. (2010) · Cell · doi:10.1016/j.cell.2010.01.020 · Cited by 585 · see citing works

The Antiviral Activities of Artemisinin and Artesunate

Efferth, T., Romero, M. R., Wolf, D. G., Stamminger, T., Marin, J. J. G., & Marschall, M. (2008) · Clinical Infectious Diseases · doi:10.1086/591195 · Cited by 503 · see citing works

Systems analysis of immunity to influenza vaccination across multiple years and in diverse populations reveals shared molecular signatures

Nakaya, H. I., Hagan, T., Duraisingham, S. S., Lee, E. K., Kwissa, M., Rouphael, N., Frasca, D., Gersten, M., Mehta, A. K., Gaujoux, R., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.11.012 · Cited by 337 · see citing works

Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia

Kamphuis, E., Junt, T., Waibler, Z., Forster, R., & Kalinke, U. (2006) · Blood · doi:10.1182/blood-2006-06-027599 · Cited by 306 · see citing works

Illuminating viral infections in the nervous system

McGavern, D. B., & Kang, S. S. (2011) · Nature Reviews Immunology · doi:10.1038/nri2971 · Cited by 281 · see citing works

Central role of mitochondria in drug-induced liver injury

Pessayre, D., Fromenty, B., Berson, A., Robin, M.-A., Lettéron, P., Moreau, R., & Mansouri, A. (2012) · Drug Metabolism Reviews · doi:10.3109/03602532.2011.604086 · Cited by 277 · see citing works

A metagenomic analysis of pandemic influenza A (2009 H1N1) infection in patients from North America

Greninger, A. L., Chen, E. C., Sittler, T., Scheinerman, A., Roubinian, N., Yu, G., Kim, E., Pillai, D. R., Guyard, C., Mazzulli, T., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013381 · Cited by 193 · see citing works

The Interferon Inducible Gene: Viperin

Fitzgerald, K. A. (2011) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2010.0127 · Cited by 163 · see citing works

Fever and sickness behavior: Friend or foe?

Harden, L. M., Kent, S., Pittman, Q. J., & Roth, J. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.07.012 · Cited by 161 · see citing works

Host defense function of the airway epithelium in health and disease: clinical background

Message, S. D., & Johnston, S. L. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0703315 · Cited by 159 · see citing works

Human induced pluripotent stem cell–derived cardiomyocytes as an in vitro model for coxsackievirus B3–induced myocarditis and antiviral drug screening platform

Sharma, A., Marceau, C., Hamaguchi, R., Burridge, P. W., Rajarajan, K., Churko, J. M., Wu, H., Sallam, K. I., Matsa, E., Sturzu, A. C., et al. (2014) · Circulation Research · doi:10.1161/circresaha.115.303810 · Cited by 148 · see citing works

Impaired Innate Host Defense Causes Susceptibility to Respiratory Virus Infections in Cystic Fibrosis

Zheng, S., De, B. P., Choudhary, S., Comhair, S. A. A., Goggans, T., Slee, R., Williams, B. R. G., Pilewski, J., Haque, S. J., & Erzurum, S. C. (2003) · Immunity · doi:10.1016/s1074-7613(03)00114-6 · Cited by 125 · see citing works

The mengovirus leader protein blocks interferon-α/β gene transcription and inhibits activation of interferon regulatory factor 3: Mengovirus L blocks IFN transcription and IRF-3 activation

Hato, S. V., Ricour, C., Schulte, B. M., Lanke, K. H. W., de Bruijni, M., Zoll, J., Melchers, W. J. G., Michiels, T., & van Kuppeveld, F. J. M. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.01006.x · Cited by 118 · see citing works

The zinc finger antiviral protein acts synergistically with an interferon-induced factor for maximal activity against alphaviruses

MacDonald, M. R., Machlin, E. S., Albin, O. R., & Levy, D. E. (2007) · Journal of Virology · doi:10.1128/jvi.00402-07 · Cited by 88 · see citing works

Nanotechnology advances in pathogen- and host-targeted antiviral delivery: multipronged therapeutic intervention for pandemic control

Yang, K.-C., Lin, J.-C., Tsai, H.-H., Hsu, C.-Y., Shih, V., & Hu, C.-M. J. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-00965-y · Cited by 39 · see citing works

Alphaherpesvirus infection of mice primes PNS neurons to an inflammatory state regulated by TLR2 and type I IFN signaling.

Laval, K., Van Cleemput, J., Vernejoul, J. B., & Enquist, L. W. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1008087 · Cited by 36 · see citing works

Toll-like receptor 3 and RIG-I-like receptor activation induces innate antiviral responses in mouse ovarian granulosa cells

Yan, K., Zhu, W., Yu, L., Li, N., Zhang, X., Liu, P., Chen, Q., Chen, Y., & Han, D. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.03.027 · Cited by 26 · see citing works

Mechanism of Protein Kinase R Inhibition by Human Cytomegalovirus pTRS1

Vincent, H. A., Ziehr, B., & Moorman, N. J. (2017) · Journal of Virology · doi:10.1128/jvi.01574-16 · Cited by 21 · see citing works

Protection from Interferon-Induced Apoptosis by Epstein-Barr Virus Small RNAs Is Not Mediated by Inhibition of PKR

Ruf, I. K., Lackey, K. A., Warudkar, S., & Sample, J. T. (2005) · Journal of Virology · doi:10.1128/jvi.79.23.14562-14569.2005 · Cited by 70 · see citing works

IRE1α mediates PKR activation in response to Chlamydia trachomatis infection

Webster, S. J., Ellis, L., O’Brien, L. M., et al. (2016) · Microbes and Infection · doi:10.1016/j.micinf.2016.03.010 · Cited by 36 · see citing works

Activation of protein kinase R is required for induction of stress granules by respiratory syncytial virus but dispensable for viral replication

Lindquist, M. E., Mainou, B. A., Dermody, T. S., & Crowe, J. E. (2011) · Virology · doi:10.1016/j.virol.2011.02.009 · Cited by 72 · see citing works

Interaction of the Human Protein Kinase PKR with the Mouse PKR Homolog Occurs via the N-Terminal Region of PKR and Does Not Inactivate Autophosphorylation Activity of Mouse PKR

Rende-Fournier, R., Ortega, L. G., George, C. X., & Samuel, C. E. (1997) · Virology · doi:10.1006/viro.1997.8824 · Cited by 12 · see citing works