Cited by 388T-cell and Retrovirus StudiesVirus-based gene therapy researchHIV Research and Treatment

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Retroviral DNA integration: Structure of an integration intermediate

Fujiwara, Tamio, Mizuuchi, Kiyoshi·1988·Cell

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Abstract

The structure of a presumptive DNA intermediate in the integration of retroviral DNA was studied in a cell-free reaction with exogenously added target DNA. The product made by viral core particles of Moloney murine leukemia virus (Mo-MLV) containing linear viral DNA has a structure consistent with an integration mechanism similar to that observed during bacteriophage Mu transposition. In this intermediate, the 3' ends of the LTR sequences are joined to the target DNA, while the 5' ends of the viral DNA remain unjoined. The 5' ends of the LTR sequences in the intermediate are exactly the same as those found in the unintegrated linear double-stranded viral DNA. This result demonstrates that the linear form of Mo-MLV DNA can integrate directly without prior circularization.

Integrity signals

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Crossref · 10.1016/0092-8674(88)90071-2

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A QM/MM study of the reaction mechanism for the 3′-processing step catalyzed by HIV-1 integrase
Ruiz‐Pernía, J. J., Alves, C. N., Moliner, V., Silla, E., & Tuñón, I. (2008) · Journal of Molecular Structure THEOCHEM · doi:10.1016/j.theochem.2008.08.005 · Cited by 11
A Substitution in Rous Sarcoma Virus Integrase That Separates Its Two Biologically Relevant Enzymatic Activities
Raup‐Konsavage, W. M., Burkholder, S., Sudol, M., Harper, A. L., & Katzman, M. (2005) · Journal of Virology · doi:10.1128/jvi.79.8.4691-4699.2005 · Cited by 11
Restricted 5′-End Gap Repair of HIV-1 Integration Due to Limited Cellular dNTP Concentrations in Human Primary Macrophages
Cor-Hosmer, S. K. V., Kim, D., Daly, M. B., Daddacha, W. B., & Kim, B. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.486787 · Cited by 12
Identification of low molecular weight nuclear complexes containing integrase during the early stages of HIV-1 infection
Gérard, A., Soler, N., Ségéral, E., Belshan, M., & Emiliani, S. (2013) · Retrovirology · doi:10.1186/1742-4690-10-13 · Cited by 12
The GP(Y/F) Domain of TF1 Integrase Multimerizes when Present in a Fragment, and Substitutions in This Domain Reduce Enzymatic Activity of the Full-length Protein
Ebina, H., Chatterjee, A. G., Judson, R. L., & Levin, H. L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801354200 · Cited by 9
Host Factors in Retroviral Integration and the Selection of Integration Target Sites
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Measurement of In Vitro Integration Activity of HIV-1 Preintegration Complexes
Balasubramaniam, M., Davids, B., Addai, A. B., Pandhare, J., & Dash, C. (2017) · Journal of Visualized Experiments · doi:10.3791/54581 · Cited by 9
Subcellular Localization and Integration Activities of Rous Sarcoma Virus Reverse Transcriptase
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Moloney murine leukemia virus integration protein produced in yeast binds specifically to viral att sites
Basu, S., & VARMUS, H. E. (1990) · Journal of Virology · doi:10.1128/jvi.64.11.5617-5625.1990 · Cited by 9
Retracted
Analysis of the DNA topoisomerase‐II‐mediated cleavage of the long terminal repeat of Drosophila 1731 retrotransposon
Nahon, E., Best‐Belpomme, M., & Saucier, J.-M. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb18355.x · Cited by 9

Authors: Fujiwara, T., & Mizuuchi, K.
Affiliations: National Institutes of Health (US)
ORCID: Mizuuchi, Kiyoshi
Venue: Cell
Publisher: Elsevier BV
Published: 1988-08
Volume: 54
Issue: 4
Pages: 497-504
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(88)90071-2
OpenAlex: W1992073293
Cited by: 385
References: 34
Citations by year: 2025: 4 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 5 · 2016: 4 · 2015: 7 · 2014: 5 · 2013: 5 · 2012: 10
FWCI: 14.83
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Keywords: retroviral integration, Moloney murine leukemia virus, long terminal repeat, target DNA
MeSH terms: Cell-Free System, DNA, Recombinant, DNA, Viral, Moloney murine leukemia virus, Retroviridae

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Retroviral DNA integration: Structure of an integration intermediate

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