Cited by 388T-cell and Retrovirus StudiesVirus-based gene therapy researchHIV Research and Treatment

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Retroviral DNA integration: Structure of an integration intermediate

Fujiwara, Tamio, Mizuuchi, Kiyoshi·1988·Cell

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Abstract

The structure of a presumptive DNA intermediate in the integration of retroviral DNA was studied in a cell-free reaction with exogenously added target DNA. The product made by viral core particles of Moloney murine leukemia virus (Mo-MLV) containing linear viral DNA has a structure consistent with an integration mechanism similar to that observed during bacteriophage Mu transposition. In this intermediate, the 3' ends of the LTR sequences are joined to the target DNA, while the 5' ends of the viral DNA remain unjoined. The 5' ends of the LTR sequences in the intermediate are exactly the same as those found in the unintegrated linear double-stranded viral DNA. This result demonstrates that the linear form of Mo-MLV DNA can integrate directly without prior circularization.

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Authors: Fujiwara, T., & Mizuuchi, K.
Affiliations: National Institutes of Health (US)
ORCID: Mizuuchi, Kiyoshi
Venue: Cell
Publisher: Elsevier BV
Published: 1988-08
Volume: 54
Issue: 4
Pages: 497-504
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(88)90071-2
OpenAlex: W1992073293
Cited by: 385
References: 34
Citations by year: 2025: 4 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 5 · 2016: 4 · 2015: 7 · 2014: 5 · 2013: 5 · 2012: 10
FWCI: 14.83
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Keywords: retroviral integration, Moloney murine leukemia virus, long terminal repeat, target DNA
MeSH terms: Cell-Free System, DNA, Recombinant, DNA, Viral, Moloney murine leukemia virus, Retroviridae

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Retroviral DNA integration: Structure of an integration intermediate

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