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Cited by 264T-cell and Retrovirus StudiesHIV Research and TreatmentVirus-based gene therapy research

The DOI matches its Crossref record; 49 of the 51 references it cites were found in a registry or an index.

Structure of the termini of DNA intermediates in the integration of retroviral DNA: Dependence on IN function and terminal DNA sequence

Roth, Monica J., Schwartzberg, Pamela L., Goff, Stephen P.·1989·Cell
DOI 10.1016/0092-8674(89)90401-7
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Abstract

Linear retroviral DNA, the major precursor to the integrated provirus of the murine leukemia viruses, contains a mixture of two structures at its ends: some termini are full-length and blunt, and some have recessed 3' strands. A temporal study of the end structures showed that the proportion of the DNA with recessed ends increases during the course of infection, and suggests that the blunt ends are precursors to the recessed ends. We have examined the DNA structures of the ends of retroviral mutants defective in the integration (IN) function. The results show that the formation of the recessed ends requires the presence of IN. Finally, we have analyzed the structures at the ends of mutant genomes with alterations in the terminal DNA sequence. The exact position of the recessed 3' end can be recessed one, two, or four nucleotides relative to the 5' end. In all cases the position of the recessed 3' end correlates perfectly with, and thus presumably determines, the site of joining to the target DNA.

Overview

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Crossref · 10.1016/0092-8674(89)90401-7

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Research works printed but not linked: 1

  1. McCutchan, 1968, Enhancement of infectivity of SV40 deoxyribonucleic acid with DEAE dextran, J. Natl. Cancer Inst., 41, 351

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Metadata

Authors
Roth, M. J., Schwartzberg, P. L., & Goff, S. P.
Affiliations
  • University of Medicine and Dentistry of New Jersey (US)
  • Columbia University Irving Medical Center (US)
ORCID
Venue
Cell
Publisher
Elsevier BV
Published
1989-07
Volume
58
Issue
1
Pages
47-54
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/0092-8674(89)90401-7
OpenAlex
W2095816327
Cited by
263
References
51
Citations by year
2026: 2 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 6 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 5 · 2015: 7 · 2014: 3 · 2013: 3 · 2012: 1
FWCI
9.66
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Cancer Institute (CA 30488)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Keywords
retroviral integration, integrase, DNA termini, murine leukemia virus, proviral DNA, integration site selection
MeSH terms
Animals, Base Sequence, Cell Transformation, Viral, Cells, Cultured, DNA, Viral, Leukemia Virus, Murine, Mutation, Recombination, Genetic, Structure-Activity Relationship, Mice, Rats

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