Cited by 264T-cell and Retrovirus StudiesHIV Research and TreatmentVirus-based gene therapy research

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Structure of the termini of DNA intermediates in the integration of retroviral DNA: Dependence on IN function and terminal DNA sequence

Roth, Monica J., Schwartzberg, Pamela L., Goff, Stephen P.·1989·Cell

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Abstract

Linear retroviral DNA, the major precursor to the integrated provirus of the murine leukemia viruses, contains a mixture of two structures at its ends: some termini are full-length and blunt, and some have recessed 3' strands. A temporal study of the end structures showed that the proportion of the DNA with recessed ends increases during the course of infection, and suggests that the blunt ends are precursors to the recessed ends. We have examined the DNA structures of the ends of retroviral mutants defective in the integration (IN) function. The results show that the formation of the recessed ends requires the presence of IN. Finally, we have analyzed the structures at the ends of mutant genomes with alterations in the terminal DNA sequence. The exact position of the recessed 3' end can be recessed one, two, or four nucleotides relative to the 5' end. In all cases the position of the recessed 3' end correlates perfectly with, and thus presumably determines, the site of joining to the target DNA.

Integrity signals

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Crossref · 10.1016/0092-8674(89)90401-7

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DNA sequencing with chain-terminating inhibitors
Sanger, F., Nicklen, S., & Coulson, A. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5463 · Cited by 68,572
Genomic sequencing.
Church, G. M., & Gilbert, W. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.7.1991 · Cited by 8,213
[2] New M13 vectors for cloning
Messing, J. W. (1983) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(83)01005-8 · Cited by 5,240
Selective extraction of polyoma DNA from infected mouse cell cultures
Hirt, B. (1967) · Journal of Molecular Biology · doi:10.1016/0022-2836(67)90307-5 · Cited by 5,102
Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.
Southern, P. J., & Berg, P. R. (1982) · PubMed · Cited by 2,740
Transformation of mammalian cells with genes from procaryotes and eucaryotes
Wigler, M. H., Sweet, R. W., Sim, G.-K., Wold, B. J., Pellicer, À., Lacy, E., Maniatis, T., Silverstein, S. J., & Axel, R. (1979) · Cell · doi:10.1016/0092-8674(79)90093-x · Cited by 1,407
A safe packaging line for gene transfer: separating viral genes on two different plasmids
Markowitz, D., Goff, S. P., & Bank, A. (1988) · Journal of Virology · doi:10.1128/jvi.62.4.1120-1124.1988 · Cited by 1,062
Self-citation
Enhancement of the Infectivity of Simian Virus 40 Deoxyribonucleic Acid With Diethylaminoethyl-Dextran 2
McCutchan, J. H., & Pagano, J. S. (1968) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/41.2.351 · Cited by 775
A detailed model of reverse transcription and tests of crucial aspects
Gilboa, E., Mitra, S. W., Goff, S., & Baltimore, D. (1979) · Cell · doi:10.1016/0092-8674(79)90357-x · Cited by 612
Self-citation
Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent haematopoietic precursors
Keller, G. M., Paige, C. J., Gilboa, E., & Wagner, E. F. (1985) · Nature · doi:10.1038/318149a0 · Cited by 572

Show all 51 references

Research works printed but not linked: 1

McCutchan, 1968, Enhancement of infectivity of SV40 deoxyribonucleic acid with DEAE dextran, J. Natl. Cancer Inst., 41, 351

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Kalpana, G. V., & Goff, S. P. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.22.10593 · Cited by 63
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Suoniemi, A., Schmidt, D., & Schulman, A. H. (1997) · Contemporary issues in genetics and evolution · doi:10.1007/978-94-011-4898-6_22 · Cited by 62
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Gorelick, R. J., Fu, W., Gagliardi, T. D., Bosche, W. J., Rein, A. R., Henderson, L. E., & Arthur, L. O. (1999) · Journal of Virology · doi:10.1128/jvi.73.10.8185-8195.1999 · Cited by 60
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Fitzgerald, M. L., Vora, A. C., Zeh, W. G., & Grandgenett, D. P. (1992) · Journal of Virology · doi:10.1128/jvi.66.11.6257-6263.1992 · Cited by 59
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Jonsson, C. B., Donzella, G. A., & Roth, M. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54098-9 · Cited by 59
Self-citation

Authors: Roth, M. J., Schwartzberg, P. L., & Goff, S. P.
Affiliations: University of Medicine and Dentistry of New Jersey (US)
Columbia University Irving Medical Center (US)
ORCID: Roth, Monica J.
Schwartzberg, Pamela L.
Goff, Stephen P.
Venue: Cell
Publisher: Elsevier BV
Published: 1989-07
Volume: 58
Issue: 1
Pages: 47-54
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(89)90401-7
OpenAlex: W2095816327
Cited by: 263
References: 51
Citations by year: 2026: 2 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 6 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 5 · 2015: 7 · 2014: 3 · 2013: 3 · 2012: 1
FWCI: 9.66
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (CA 30488)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
Keywords: retroviral integration, integrase, DNA termini, murine leukemia virus, proviral DNA, integration site selection
MeSH terms: Animals, Base Sequence, Cell Transformation, Viral, Cells, Cultured, DNA, Viral, Leukemia Virus, Murine, Mutation, Recombination, Genetic, Structure-Activity Relationship, Mice, Rats

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Structure of the termini of DNA intermediates in the integration of retroviral DNA: Dependence on IN function and terminal DNA sequence

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