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Drosophila abl tyrosine kinase in embryonic CNS axons: A role in axonogenesis is revealed through dosage-sensitive interactions with disabled

Gertler, Frank B., Bennett, Randy L., Clark, Michael J., Hoffmann, F.Michael·1989·Cell
DOI 10.1016/0092-8674(89)90407-8
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Abstract

During Drosophila embryogenesis, the Abelson tyrosine kinase (abl) is localized in the axons of the central nervous system (CNS). Mutations in abl have no detectable effect on the morphology of the embryonic CNS, and the mutant animals survive to the pupal and adult stages. In the absence of abl function, however, heterozygous mutations or deletions of disabled (dab) exert dominant effects, disrupting axonal organization and shifting the lethal phase of the animals to embryonic and early larval stages. Embryos that are homozygous mutant for both abl and dab fail to develop any axon bundles in the CNS, although the peripheral nervous system and the larval cuticle appear normal. The genetic interaction between these two genes begins to define a process in which both the abl tyrosine kinase and the dab gene product participate in establishing axonal connections in the embryonic CNS of Drosophila.

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  • Mammalian Dab2 and neuron-specific Dab1 are orthologs of Drosophila Disabled.

    “Sequence alignment indicated that mammalian Dab2 and a neuron specific isoform Dab1 are orthologs of the Drosophila Disabled gene”

    From Endocytosis and Physiology: Insights from Disabled-2 Deficient Mice (2016) · cites this paper as Gertler et al., 1989

  • Dab2 is one of two mammalian orthologs of the Drosophila Disabled (dDab), a family member of the Disabled proteins involved in neurogenesis, oncogenesis, cellular signaling and embryonic development.

    “Subsequent studies indicated Dab2 as one of two mammalian orthologs of the Drosophila Disabled (dDab) [8-11], a family member of the Disabled proteins involved in neurogenesis, oncogenesis, cellular signaling and embryonic development.”

    From Dynamic expression of Dab2 in the mouse embryonic central nervous system (2008) · cites this paper as [8]

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Research works printed but not linked: 66

  1. Alemà, 1985, Differentiation of PC12 phaeochromocytoma cells induced by v-src oncogene, Nature, 316, 557, 10.1038/316557a0 · DOI
  2. Banerjee, 1987, Molecular characterization and expression of sevenless, a gene involved in neuronal pattern formation in the Drosophila eye, Cell, 49, 281, 10.1016/0092-8674(87)90569-1 · DOI
  3. Banerjee, 1987, The sevenless+ protein is expressed apically in cell membranes of developing Drosophila retina; it is not restricted to cell R7, Cell, 51, 151, 10.1016/0092-8674(87)90020-1 · DOI
  4. Basler, 1988, Sevenless and Drosophila eye development: a tyrosine kinase controls cell fate, Trends Genet., 4, 74, 10.1016/0168-9525(88)90044-3 · DOI
  5. Bastiani, 1987, Expression of fasciclin I and II glycoproteins on subsets of axon pathways during neuronal development in the grasshopper, Cell, 48, 745, 10.1016/0092-8674(87)90072-9 · DOI
  6. Brugge, 1985, Neurons express high levels of a structurally modified activated form of pp60c-src, Nature, 316, 554, 10.1038/316554a0 · DOI
  7. Campos, 1985, Mutant alleles at the locus elav in Drosophila melanogaster lead to nervous system defects, J. Neurogenet., 2, 197, 10.3109/01677068509100150 · DOI
  8. Canal, 1986, The pattern of early neuronal differentiation in Drosophila melanogaster, J. Neurogenet., 3, 293, 10.3109/01677068609106856 · DOI
  9. Carroll, 1987, Production and purification of polyclonal antibodies to the foreign segment of β-galactosidase fusion proteins, Vol. 3, 89
  10. Craymer, 1984, New mutants, Dros. Inf. Serv., 60, 234
  11. Crews, 1988, The Drosophila single-minded gene encodes a nuclear protein with sequence similarity to the per gene product, Cell, 52, 143, 10.1016/0092-8674(88)90538-7 · DOI
  12. Cronmiller, 1987, The Drosophila sex determination gene daughterless has different functions in the germ line versus the soma, Cell, 48, 479, 10.1016/0092-8674(87)90198-X · DOI
  13. Desai, 1988, A genetic pathway for the development of Caenorhabditis elegans HSN motor neurons, Nature, 336, 638, 10.1038/336638a0 · DOI
  14. Edwards, 1988, Myelin-associated glycoprotein, a cell adhesion molecule of oligodendrocytes, is phosphorylated in brain, Mol. Cell. Biol., 8, 2655, 10.1128/MCB.8.6.2655 · DOI
  15. Fults, 1985, pp60c-src in the developing cerebellum, Mol. Cell. Biol., 5, 27, 10.1128/MCB.5.1.27 · DOI
  16. Ghysen, 1986, Sensory neurons and peripheral pathways in Drosophila embryos, Roux's Arch. Dev. Biol., 195, 281, 10.1007/BF00376060 · DOI
  17. Goslin, 1988, Development of neuronal polarity: GAP-43 distinguishes axonal from dendritic growth cones, Nature, 336, 672, 10.1038/336672a0 · DOI
  18. Gregory, 1987, Primary sequence and developmental expression of a novel Drosophila melanogaster src gene, Mol. Cell. Biol., 7, 2119, 10.1128/MCB.7.6.2119 · DOI
  19. Hafen, 1987, Sevenless, a cell-specific homeotic gene of Drosophila, encodes a putative transmembrane receptor with a tyrosine kinase domain, Science, 236, 55, 10.1126/science.2882603 · DOI
  20. Haller, 1987, Dorsal and neural expression of a tyrosine kinase-related Drosophila gene during embryonic development, Genes Dev., 1, 862, 10.1101/gad.1.8.862 · DOI
  21. Hanks, 1988, The protein kinase family: conserved features and deduced phylogeny of the catalytic domains, Science, 241, 42, 10.1126/science.3291115 · DOI
  22. Hartenstein, 1985, Fate-mapping in wild-type Drosophila melanogaster. I. The spatio-temporal pattern of embryonic cell divisions, Roux's Arch. Dev. Biol., 194, 181, 10.1007/BF00848246 · DOI
  23. Henkemeyer, 1987, The Drosophila Abelson proto-oncogene homolog: identification of mutant alleles that have pleiotropic effects late in development, Cell, 51, 821, 10.1016/0092-8674(87)90105-X · DOI
  24. Henkemeyer, 1988, DNA sequence, structure, and tyrosine kinase activity of the Drosophila melanogaster Abelson proto-oncogene homolog, Mol. Cell. Biol., 8, 843, 10.1128/MCB.8.2.843 · DOI
  25. Hoffmann, 1989, Roles of Drosophila proto-oncogene and growth factor homologs during development of the fly, 10.1007/978-3-642-74697-0_1 · DOI
  26. Hopfield, 1988, Functional modulation of the nicotinic acetylcholine receptor by tyrosine phosphorylation, Nature, 336, 677, 10.1038/336677a0 · DOI
  27. Hunter, 1986, Viral oncogenes and tyrosine phosphorylation, Vol. 17, 191
  28. Jacobs, 1989, Embryonic development of axon pathways in the Drosophila CNS: behavior of pioneer growth cones, J. Neurosci.
  29. Jiménez, 1987, Genes in subdivision 1 of the Drosophila melanogaster X-chromosome and their influence on neural development, J. Neurogenet, 4, 179
  30. Kellie, 1988, Cellular transformation, tyrosine kinase oncogenes, and the cellular adhesion plaque, Bioessays, 8, 25, 10.1002/bies.950080107 · DOI
  31. Kopczynski, 1988, Delta, a Drosophila neurogenic gene, is transcriptionally complex and encodes a protein related to blood coagulation factors and epidermal growth factor of vertebrates, Genes Dev., 2, 1723, 10.1101/gad.2.12b.1723 · DOI
  32. Laemmli, 1970, Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature., 227, 680, 10.1038/227680a0 · DOI · Paper page
  33. Lehmann, 1983, On the phenotype and development of mutants of early neurogenesis in Drosophila melanogaster, Roux's Arch. Dev. Biol., 192, 62, 10.1007/BF00848482 · DOI
  34. Lewis, 1968, Method for feeding ethyl methane sulfonate (EMS) to Drosophila males, Dros. Info. Serv., 43, 193
  35. Lindsley, 1968, Genetic variation of Drosophila melanogaster, Carnegie Inst. Washington Publ. No. 627
  36. Lindsley, 1985, The genome of Drosophila melanogaster, Part I: Genes A-K, Dros. Info. Serv., 62
  37. Lindsley, 1986, The genome of Drosophila melanogaster, Part 2: Lethals, maps, Dros. Info. Serv., 64
  38. Lindsley, 1987, The genome of Drosophila melanogaster, Part 3: Rearrangements, Dros. Info. Serv., 65
  39. Martinez, 1987, Neuronal pp60c-src contains a six-amino acid insertion relative to its non-neuronal counterpar, Science, 237, 411, 10.1126/science.2440106 · DOI
  40. Mayer, 1988, A group of genes required for pattern formation in the ventral ectoderm of the Drosophila embryo, Genes Dev., 2, 1496, 10.1101/gad.2.11.1496 · DOI
  41. Patel, 1987, Characterization and cloning of Fasciclin III: a glycoprotein expressed on a subset of neurons and axon pathways in Drosophila, Cell, 48, 975, 10.1016/0092-8674(87)90706-9 · DOI
  42. Pawson, 1988, Non-catalytic domains of cytoplasmic proteintyrosine kinases: regulatory elements in signal transduction, Oncogene, 3, 491
  43. Polson, 1980, Antibodies to proteins from yolk of immunized hens, Immunol. Commun., 9, 495, 10.3109/08820138009066011 · DOI
  44. Price, 1989, The maternal ventralizing locus torpedo is allelic to faint little ball, an embryonic lethal, and encodes the Drosophila EGF receptor homolog, Cell, 56, 1085, 10.1016/0092-8674(89)90641-7 · DOI
  45. Regan, 1988, Interacting genes that affect microtubule function: the nc2 allele of the haywire locus fails to complement mutations in the testis-specific beta-tubulin gene of Drosophila, Genes Dev., 2, 82, 10.1101/gad.2.1.82 · DOI
  46. Renshaw, 1988, Differential expression of type-specific c-abl mRNAs in mouse tissues and cell lines, Mol. Cell. Biol., 8, 4547, 10.1128/MCB.8.10.4547 · DOI
  47. Robinow, 1988, The locus elav of Drosophila melanogaster is expressed in neurons at all developmental stages, Dev. Biol., 126, 294, 10.1016/0012-1606(88)90139-X · DOI
  48. Robinow, 1988, The elav gene product of Drosophila, required in neurons, has three RNP consensus motifs, Science, 242, 1570, 10.1126/science.3144044 · DOI
  49. Rothberg, 1988, slit: an EGF-homologous locus of D. melanogaster involved in the development of the embryonic central nervous system, Cell, 55, 1047, 10.1016/0092-8674(88)90249-8 · DOI
  50. Schejter, 1989, The Drosophila EGF receptor homolog (DER) gene is allelic to faint little ball, a locus essential for embryonic development, Cell, 56, 1093, 10.1016/0092-8674(89)90642-9 · DOI
  51. Schejter, 1986, Alternative 5′ exons and tissue-specific expression of the Drosophila EGF receptor homolog transcripts, Cell, 46, 1091, 10.1016/0092-8674(86)90709-9 · DOI
  52. Seeger, 1988, Characterization of amalgam: a member of the immunoglobulin superfamily from Drosophila, Cell, 55, 589, 10.1016/0092-8674(88)90217-6 · DOI
  53. Simon, 1985, The nucleotide sequence and the tissue-specific expression of Drosophila c-src, Cell, 42, 831, 10.1016/0092-8674(85)90279-X · DOI
  54. Sorge, 1984, pp60c-src Is developmentally regulated in the neural retina, Cell, 36, 249, 10.1016/0092-8674(84)90218-6 · DOI
  55. Telford, 1985, Alternative processing and developmental control of the transcripts of the Drosophila abl oncogene homologue, EMBO J., 4, 2609, 10.1002/j.1460-2075.1985.tb03978.x · DOI
  56. Thomas, 1984, From grasshopper to Drosophila: a common plan for neuronal development, Nature, 310, 203, 10.1038/310203a0 · DOI
  57. Thomas, 1988, Molecular genetics of the single-minded locus: a gene involved in the development of the Drosophila nervous system, Cell, 52, 133, 10.1016/0092-8674(88)90537-5 · DOI
  58. Tillotsen, 1989, Tyrosine phosphorylation in the postnatal rat brain: a developmental, immunohistochemical study, J. Comp. Neurol., 10.1002/cne.902820110 · DOI
  59. Tomlinson, 1989, Cellular interaction in the developing Drosophila eye, Development, 104, 183, 10.1242/dev.104.2.183 · DOI
  60. Vässin, 1985, Genetic interactions in early neurogenesis of Drosophila melanogaster, J. Neurogenet, 2, 291, 10.3109/01677068509102325 · DOI
  61. Vässin, 1987, The neurogenic gene Delta of Drosophila melanogaster is expressed in neurogenic territories and encodes a putative transmembrane protein with EGF-like repeats, EMBO J., 6, 3431, 10.1002/j.1460-2075.1987.tb02666.x · DOI
  62. Vincent, 1989, Embryonic expression of a Drosophila src gene: alternate forms of the protein are expressed in segmental stripes and in the nervous system, Genes Dev., 3, 334, 10.1101/gad.3.3.334 · DOI
  63. Wharton, 1985, Nucleotide sequence from the neurogenic locus Notch implies a gene product that shares homology with proteins containing EGF-like repeats, Cell, 43, 567, 10.1016/0092-8674(85)90229-6 · DOI
  64. White, 1980, Defective neural development in Drosophila melanogaster embryos deficien for the tip of the X chromosome, Dev. Biol., 80, 332, 10.1016/0012-1606(80)90409-1 · DOI
  65. Zhao, 1988, zipper encodes a putative integral membrane protein required for normal axon patterning during Drosophila neurogenesis, EMBO J., 7, 1115, 10.1002/j.1460-2075.1988.tb02920.x · DOI
  66. Zinn, 1988, Sequence analysis and neuronal expression of fasciclin I in grasshopper and Drosophila, Cell, 53, 577, 10.1016/0092-8674(88)90574-0 · DOI

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Metadata

Authors
Gertler, F. B., Bennett, R. L., Clark, M. J., & Hoffmann, F. M.
Venue
Cell
Publisher
Elsevier BV
Published
1989-07
Volume
58
Issue
1
Pages
103-113
ISSN
0092-8674
DOI
10.1016/0092-8674(89)90407-8
Cited by
207
References
0
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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