The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Yeast centromere binding protein CBF1, of the helix-loop-helix protein family, is required for chromosome stability and methionine prototrophy
Open accessAbstract
The centromere and its binding proteins constitute the kinetochore structure of metaphase chromosomes, which is crucial for the high accuracy of the chromosome segregation process. Isolation and analysis of the gene encoding a centromere binding protein from the yeast S. cerevisiae, CBF1, are described in this paper. DNA sequence analysis of the CBF1 gene reveals homology with the transforming protein myc and a family of regulatory proteins known as the helix-loop-helix (HLH) proteins. Disruption of the CBF1 gene caused a decrease in the growth rate, an increase in the rate of chromosome loss/nondisjunction, and hypersensitivity to the antimitotic drug thiabendazole. Unexpectedly, the cbf1 null mutation concomitantly resulted in a methionine auxotrophic phenotype, which suggests that CBF1, like other HLH proteins in higher eukaryotic cells, participates in the regulation of gene expression.
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Metadata
- Authors
- Cai, M., & Davis, R. W.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1990-05
- Volume
- 61
- Issue
- 3
- Pages
- 437-446
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1993886320
- Cited by
- 335
- References
- 49
- FWCI
- 19.14
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Cai, M., & Davis, R. W. (1990). Yeast centromere binding protein CBF1, of the helix-loop-helix protein family, is required for chromosome stability and methionine prototrophy. Cell. https://doi.org/10.1016/0092-8674(90)90525-j
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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