The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Differences and Similarities in DNA-Binding Preferences of MyoD and E2A Protein Complexes Revealed by Binding Site Selection
Abstract
A technique was developed for studying protein-DNA recognition that can be applied to any purified protein, partially purified protein, or cloned gene. From oligonucleotides in which particular positions are of random sequence, that subset to which a given protein binds is amplified by the polymerase chain reaction and sequenced as a pool. These selected and amplified binding site (SAAB) "imprints" provide a characteristic set of preferred sequences for protein binding. With this technique, it was shown that homo- and heterooligomers of the helix-loop-helix proteins MyoD and E2A recognize a common consensus sequence, CA--TG, but otherwise bind to flanking and internal positions with different sequence preferences that suggest half-site recognition. These findings suggest that different combinations of dimeric proteins can have different binding sequence preferences.
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Citations
Cites
The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation
Davis, R. L., Cheng, P.-F., Lassar, A. B., & Weintraub, H. (1990) · Cell · doi:10.1016/0092-8674(90)90088-v · Cited by 765
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Cited by
Genome editing with engineered zinc finger nucleases
Urnov, F. D., Rebar, E. J., Holmes, M. C., Zhang, H. S., & Gregory, P. D. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2842 · Cited by 2,285
Role of arabidopsis MYC and MYB homologs in drought- and abscisic acid-regulated gene expression.
Abe, H., Yamaguchi-Shinozaki, K., Urao, T., Iwasaki, T., Hosokawa, D., & Shinozaki, K. (1997) · The Plant Cell · doi:10.1105/tpc.9.10.1859 · Cited by 1,049
Conversion of Xenopus Ectoderm into Neurons by NeuroD, a Basic Helix-Loop-Helix Protein
Lee, J. E., Hollenberg, S. M., Snider, L., Turner, D. L., Lipnick, N., & Weintraub, H. (1995) · Science · doi:10.1126/science.7754368 · Cited by 1,023
Self-citationPrendergast, G. C., Lawe, D., & Ziff, E. B. (1991) · Cell · doi:10.1016/0092-8674(91)90457-a · Cited by 558
Jen, Y., Weintraub, H., & Benezra, R. (1992) · Genes & Development · doi:10.1101/gad.6.8.1466 · Cited by 471
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Metadata
- Authors
- Blackwell, T. K., & Weintraub, H.
- Venue
- Science
- Published
- 1990-11-23
- Volume
- 250
- Issue
- 4984
- Pages
- 1104-1110
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2019673480
- Cited by
- 930
- References
- 1
- FWCI
- 27.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- Blackwell, T. K., & Weintraub, H. (1990). Differences and Similarities in DNA-Binding Preferences of MyoD and E2A Protein Complexes Revealed by Binding Site Selection. Science. https://doi.org/10.1126/science.2174572
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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