Metabolism of sulfur amino acids in Saccharomyces cerevisiae.
Open accessAbstract
Sulfur amino acid biosynthesis in Saccharomyces cerevisiae involves a large number of enzymes required for the de novo biosynthesis of methionine and cysteine and the recycling of organic sulfur metabolites. This review summarizes the details of these processes and analyzes the molecular data which have been acquired in this metabolic area. Sulfur biochemistry appears not to be unique through terrestrial life, and S. cerevisiae is one of the species of sulfate-assimilatory organisms possessing a larger set of enzymes for sulfur metabolism. The review also deals with several enzyme deficiencies that lead to a nutritional requirement for organic sulfur, although they do not correspond to defects within the biosynthetic pathway. In S. cerevisiae, the sulfur amino acid biosynthetic pathway is tightly controlled: in response to an increase in the amount of intracellular S-adenosylmethionine (AdoMet), transcription of the coregulated genes is turned off. The second part of the review is devoted to the molecular mechanisms underlying this regulation. The coordinated response to AdoMet requires two cis-acting promoter elements. One centers on the sequence TCACGTG, which also constitutes a component of all S. cerevisiae centromeres. Situated upstream of the sulfur genes, this element is the binding site of a transcription activation complex consisting of a basic helix-loop-helix factor, Cbf1p, and two basic leucine zipper factors, Met4p and Met28p. Molecular studies have unraveled the…
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In Saccharomyces cerevisiae, hydrogen sulfide is the product of the Sulfate Reduction Sequence (SRS) pathway and acts as an intermediate in the biosynthesis of sulfur-containing amino acids.
“In Saccharomyces cerevisiae, hydrogen sulfide is the product of the Sulfate Reduction Sequence (SRS) pathway and acts as an intermediate in the biosynthesis of sulfurcontaining amino acids (Yamagata 1989, Rauhut 1993, Thomas and Surdin-Kerjan 1997).”
From Yeast and bacterial modulation of wine aroma and flavour (2005) · cites this paper as Thomas and Surdin-Kerjan 1997
Surplus sulfide is liberated from the cell as hydrogen sulfide.
“Surplus sulfide is then liberated from the cell as hydrogen sulfide (Thomas and Surdin-Kerjan 1997).”
From Yeast and bacterial modulation of wine aroma and flavour (2005) · cites this paper as Thomas and Surdin-Kerjan 1997
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Yeast and bacterial modulation of wine aroma and flavour
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- Authors
- Thomas, D., & Surdin-Kerjan, Y.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Venue
- Microbiology and molecular biology reviews : MMBR
- Publisher
- American Society for Microbiology
- Published
- 1997
- Volume
- 61
- Issue
- 4
- Pages
- 503-532
- ISSN
- 1092-2172 (ISSN-L)
- PMC
- PMC232622
- OpenAlex
- W2165934569
- Cited by
- 678
- References
- 1
- Citations by year
- 2026: 10 · 2025: 10 · 2024: 24 · 2023: 26 · 2022: 21 · 2021: 20 · 2020: 21 · 2019: 24 · 2018: 32 · 2017: 39 · 2016: 24 · 2015: 21 · 2014: 22 · 2013: 21 · 2012: 35
- FWCI
- 3.94
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Microbiology and Molecular Biology Reviews (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Association pour la Recherche sur le Cancer
- Centre National de la Recherche Scientifique
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nitrogen and Sulfur Effects on Brassica
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Keywords
- methionine biosynthesis, cysteine biosynthesis, sulfur metabolism, S-adenosylmethionine, transcriptional regulation, zinc finger proteins, bZIP transcription factors, bHLH transcription factors, Saccharomyces cerevisiae
- MeSH terms
- Amino Acids, Sulfur, Cysteine, Methionine, Saccharomyces cerevisiae, Transcription, Genetic, Gene Expression Regulation, Fungal
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