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A critical role of λ5 protein in B cell development

Kitamura, Daisuke, Kudo, Akira, Schaal, Stefan, Müller, Werner, Melchers, Fritz, Rajewsky, Klaus·1992·Cell
DOI 10.1016/0092-8674(92)90293-l
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Abstract

The lambda 5 gene is a homolog of immunoglobulin J lambda-C lambda genes, expressed specifically in immature B-lineage cells. Lambda 5-encoded molecules form membrane complexes with mu or D mu proteins in association with an additional protein specifically expressed in immature B cells that is encoded by the Vpre-B gene. We have generated mice in which the lambda 5 gene is inactivated by targeted gene disruption in embryonic stem cells. In these mice, B cell development in the bone marrow is blocked at the pre-B cell stage. However, the blockade is leaky, allowing B cells to populate the peripheral immune system at a low rate. These cells are allelically excluded and able to respond to antigen.

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Metadata

Authors
Kitamura, D., Kudo, A., Schaal, S., Müller, W., Melchers, F., & Rajewsky, K.
Venue
Cell
Publisher
Elsevier BV
Published
1992-05
Volume
69
Issue
5
Pages
823-831
ISSN
0092-8674
DOI
10.1016/0092-8674(92)90293-l
Cited by
449
References
0
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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