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Cell-specific expression of the macrophage scavenger receptor gene is dependent on PU.1 and a composite AP-1/ets motif.

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PU.1/Pip and Basic Helix Loop Helix Zipper Transcription Factors Interact With Binding Sites in the CD20 Promoter to Help Confer Lineage- and Stage-Specific Expression of CD20 in B Lymphocytes

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MOLECULAR GENETICS OF T CELL DEVELOPMENT

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Prolactin inducible protein in cancer, fertility and immunoregulation: structure, function and its clinical implications

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IRF5 and IRF5 Disease-Risk Variants Increase Glycolysis and Human M1 Macrophage Polarization by Regulating Proximal Signaling and Akt2 Activation

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EGFR inhibition evokes innate drug resistance in lung cancer cells by preventing Akt activity and thus inactivating Ets-1 function

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T Cell Lineage Commitment: Identity and Renunciation

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Adiponectin Promotes Endotoxin Tolerance in Macrophages by Inducing IRAK-M Expression

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Function of PEA3 Ets Transcription Factors in Mammary Gland Development and Oncogenesis

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Cytokine-induced myeloid differentiation is dependent on activation of the MEK/ERK pathway

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Transcriptional Regulation of the Cyclooxygenase-2 Gene in Macrophages by PU.1

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Subversion of T lineage commitment by PU.1 in a clonal cell line system

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PI3 kinase pathway regulated miRNome in glioblastoma: identification of miR-326 as a tumour suppressor miRNA

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Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis

Richards, J. S., Fan, H.-Y., Liu, Z., Tsoi, M. F., Lague, M.-N., Boyer, A., & Boerboom, D. (2011) · Oncogene · doi:10.1038/onc.2011.341 · Cited by 53 · see citing works

Leptin up-regulates TLR2 in human monocytes

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Carrier-independent Nuclear Import of the Transcription Factor PU.1 via RanGTP-stimulated Binding to Nup153

Zhong, H., Takeda, A., Nazari, R., Shio, H., Blobel, G., & Yaseen, N. R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412878200 · Cited by 40 · see citing works

Chromatin Remodeling of Colorectal Cancer Liver Metastasis is Mediated by an HGF‐PU.1‐DPP4 Axis

Wang, L., Wang, E., Balcazar, J. P., Wu, Z., Xiang, K., Wang, Y., Huang, Q., Negrete, M., Chen, K., Li, W., et al. (2021) · Advanced Science · doi:10.1002/advs.202004673 · Cited by 34 · see citing works

Functional analysis of PU.1 domains in monocyte‐specific gene regulation

Nishiyama, C., Nishiyama, M., Ito, T., Masaki, S., Masuoka, N., Yamane, H., Kitamura, T., Ogawa, H., & Okumura, K. (2004) · FEBS Letters · doi:10.1016/s0014-5793(04)00116-4 · Cited by 34 · see citing works

Mitf–PU.1 interactions with the tartrate-resistant acid phosphatase gene promoter during osteoclast differentiation

Partington, G. A., Fuller, K., Chambers, T. J., & Pondel, M. D. (2003) · Bone · doi:10.1016/j.bone.2003.11.010 · Cited by 33 · see citing works

Expression of Adipose Differentiation-Related Protein (ADRP) Is Conjointly Regulated by PU.1 and AP-1 in Macrophages

Wei, P. Y., Taniguchi, S., Sakai, Y., Imamura, M., Inoguchi, T., Nawata, H., Oda, S., Nakabeppu, Y., Nishimura, J., & Ikuyama, S. (2005) · The Journal of Biochemistry · doi:10.1093/jb/mvi136 · Cited by 28 · see citing works

Anti-Bacterial Effects of Poly-N-Acetyl-Glucosamine Nanofibers in Cutaneous Wound Healing: Requirement for Akt1

Lindner, H. B., Zhang, A., Eldridge, J. D., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018996 · Cited by 27 · see citing works

Accelerated plasma-cell differentiation in Bach2-deficient mouse B cells is caused by altered IRF4 functions

Ochiai, K., Shima, H., Tamahara, T., Sugie, N., Funayama, R., Nakayama, K., Kurosaki, T., & Igarashi, K. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00077-6 · Cited by 24 · see citing works

Long-term Monocyte Dysfunction after Sepsis in Humanized Mice Is Related to Persisted Activation of Macrophage-Colony Stimulation Factor (M-CSF) and Demethylation of PU.1, and It Can Be Reversed by Blocking M-CSF In Vitro or by Transplanting Naïve Autologous Stem Cells In Vivo

Lapko, N., Zawadka, M., Połosak, J., Worthen, G. S., Danet-Desnoyers, G. A., Puzianowska‐Kuźnicka, M., & Laudański, K. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00401 · Cited by 24 · see citing works

Regulation of PrPC expression: Nerve growth factor (NGF) activates the prion gene promoter through the MEK1 pathway in PC12 cells

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Subtle distinct regulations of late erythroid molecular events by PI3K/AKT-mediated activation of Spi-1/PU.1 oncogene autoregulation loop

Breig, O., Théoleyre, O., Douablin, A., & Baklouti, F. (2010) · Oncogene · doi:10.1038/onc.2010.29 · Cited by 19 · see citing works

A cascade of Ca2+/calmodulin-dependent protein kinases regulates the differentiation and functional activation of murine neutrophils

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Microarray Analysis of Lyn-Deficient B Cells Reveals Germinal Center-Associated Nuclear Protein and Other Genes Associated with the Lymphoid Germinal Center1

Mirnics, Z. K., Caudell, E., Gao, Y.-H., Kuwahara, K., Sakaguchi, N., Kurosaki, T., Burnside, J., Mirnics, K., & Corey, S. (2004) · Journal of Immunology · doi:10.4049/jimmunol.172.7.4133 · Cited by 22 · see citing works

p120RasGAP Is a Mediator of Rho Pathway Activation and Tumorigenicity in the DLD1 Colorectal Cancer Cell Line

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SPI-C, a PU-box binding ETS protein expressed temporarily during B-cell development and in macrophages, contains an acidic transactivation domain located to the N-terminus

Carlsson, R., Persson, C., & Leanderson, T. (2003) · Molecular Immunology · doi:10.1016/s0161-5890(03)00032-4 · Cited by 18 · see citing works

PU.1 phosphorylation correlates with hydroquinone-induced alterations in myeloid differentiation and cytokine-dependent clonogenic response in human CD34+ hematopoietic progenitor cells

Gross, S., Zheng, J.-H., Le, A., Kerzic, P. J., & Irons, R. (2006) · Cell Biology and Toxicology · doi:10.1007/s10565-006-0128-7 · Cited by 17 · see citing works

PU.1 and MYC transcriptional network defines synergistic drug responses to KIT and LSD1 inhibition in acute myeloid leukemia

Curtiss, B. M., VanCampen, J., Macaraeg, J., Kong, G., Taherinasab, A., Tsuchiya, M., Yashar, W. M., Tsang, Y. H., Horton, W. R., Coleman, D. J., et al. (2022) · Leukemia · doi:10.1038/s41375-022-01594-1 · Cited by 16 · see citing works

PU.1 immortalizes hematopoietic progenitors in a GM-CSF-dependent manner

Houston, I. B., Huang, K. J., Jennings, S. R., & DeKoter, R. P. (2007) · Experimental Hematology · doi:10.1016/j.exphem.2006.11.003 · Cited by 15 · see citing works

PU.1 is required to restrain myelopoiesis during chronic inflammatory stress

Chavez, J. S., Rabe, J. L., Niño, K. E., Wells, H. H., Gessner, R. L., Mills, T. S., Hernandez, G., & Pietras, E. M. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1204160 · Cited by 14 · see citing works

Autophagy as a pharmacological target in hematopoiesis and hematological disorders

Orsini, M., Morceau, F., Dicato, M. A., & Diederich, M. F. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.04.007 · Cited by 13 · see citing works

NF-κB-Inducing Kinase Regulates Cyclooxygenase 2 Gene Expression in Macrophages by Phosphorylation of PU.1

Azim, A. C., Wang, X., Park, G. Y., Sadikot, R. T., Cao, H., Mathew, B., Atchison, M., van Breemen, R. B., Joo, M., & Christman, J. W. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.11.7868 · Cited by 13 · see citing works

Differentiation-dependent up-regulation of p47phox gene transcription is associated with changes in PU.1 phosphorylation and increased binding affinity

Marden, C. M., Stefanidis, D., Cunninghame‐Graham, D. S., & Casimir, C. M. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00727-7 · Cited by 12 · see citing works

The Fes tyrosine kinase: a signal transducer that regulates myeloid-specific gene expression through transcriptional activation

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Adipocyte-Specific Ablation of PU.1 Promotes Energy Expenditure and Ameliorates Metabolic Syndrome in Aging Mice

Chen, K. Y., Angulo, A. D., Guo, X., More, A., Ochsner, S. A., Lopez, E., Saul, D., Pang, W., Sun, Y., McKenna, N. J., et al. (2022) · Frontiers in Aging · doi:10.3389/fragi.2021.803482 · Cited by 8 · see citing works

Editorial: PRL-Releasing Peptide Stimulation of PRL Gene Transcription—Enter AKT

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Combined inhibition of PI3K and activation of MAPK p38 signaling pathways trigger erythroid alternative splicing switch of 4.1R pre-mRNA in DMSO-induced erythroleukemia cells

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Combinatorial Control of DNase I-hypersensitive Site Formation and Erasure by Immunoglobulin Heavy Chain Enhancer-binding Proteins

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Correction: Anti-Bacterial Effects of Poly-N-Acetyl-Glucosamine Nanofibers in Cutaneous Wound Healing: Requirement for Akt1

Lindner, H. B., Zhang, A., Eldridge, J. D., et al. (2011) · PLoS ONE · doi:10.1371/annotation/3966fcd7-6127-45e0-80e6-55063875e826 · Cited by 6 · see citing works

Evidence against requirement of Ser41 and Ser45 for function of PU.1 – Molecular cloning of rat PU.1

Nishiyama, C., Masuoka, N., Nishiyama, M., Ito, T., Yamane, H., Okumura, K., & Ogawa, H. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.07.008 · Cited by 5 · see citing works

Delayed-late activation of a myeloid defensin minimal promoter by retinoids and inflammatory mediators

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Mechanism and therapeutic implications of pomalidomide-induced immune surface marker upregulation in EBV-positive lymphomas

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Enzastaurin enhances ATRA-induced differentiation of acute myeloid leukemia cells.

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PU.1 and MYC transcriptional network defines synergistic drug responses to KIT and LSD1 inhibition in acute myeloid leukemiaPreprint

Curtiss, B. M., VanCampen, J., Kong, G., Yashar, W. M., Tsang, Y. H., Horton, W. R., Coleman, D. J., Estabrook, J., Lusardi, T. A., Mills, G. B., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.24.456354 · Cited by 3 · see citing works

Feedback loops in B-cell chromatin regulation as a therapeutic target for modulating antibody production and malignancies: insights from BACH2

Ochiai, K., & Igarashi, K. (2025) · Experimental Hematology · doi:10.1016/j.exphem.2025.105284 · Cited by 2 · see citing works

Signal transduction pathways regulating granulocyte differentiation and function

Verploegen, S. A. B. W. (2002) · Utrecht University Repository (Utrecht University)

Molecular genetics of T cell development

Rothenberg, E. V., & Taghon, T. (2005) · Ghent University Academic Bibliography (Ghent University)

Brg1 regulates fibroblast-myofibroblast transition to promote renal fibrosisPreprint

Wu, X., Luo, Y., Kang, A., Ni, J., Kong, M., & Zhang, T. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.22.572996

PU.1 as a Master Regulator of Immune Cell Development and Function: Structural Basis, Gene Regulatory Networks, Disease Roles, and Therapeutic Targeting

Ramani, M., Nguyen, N., Solis, J., Tenen, D. G., & Trinh, B. Q. (2026) · Biology · doi:10.3390/biology15181657

Regulation of a Mitogen-Activated Protein Kinase Kinase Kinase, MLTK by PKN

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Activation of MEK‐1 and SEK‐1 by Tpl‐2 proto‐oncoprotein, a novel MAP kinase kinase kinase.

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A gene encoding a mitogen-activated protein kinase kinase kinase is induced simultaneously with genes for a mitogen-activated protein kinase and an S6 ribosomal protein kinase by touch, cold, and water stress in Arabidopsis thaliana.

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MEKK1 Binds Raf-1 and the ERK2 Cascade Components

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Isolation of ATMEKK1 (a MAP Kinase Kinase Kinase)-Interacting Proteins and Analysis of a MAP Kinase Cascade inArabidopsis

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