The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Imprinting and X chromosome counting mechanisms determine Xist expression in early mouse development
Abstract
In mice, X inactivation is preceded by in cis Xist expression. Initially, normal female embryos express the paternal Xist allele exclusively, preceding imprinted X inactivation in the trophectoderm. Later expression of Xist alleles is random, preceding random X inactivation in the epiblast lineage. In this study using uniparental embryos, we demonstrate that Xist expression is initially dictated solely by parental imprinting, causing expression of all paternal alleles. Maternal alleles remain repressed, irrespective of X chromosome number. At the compacting morula stage, this parental imprint is erased, and the mechanism counting the X chromosomes imposes appropriate Xist expression with respect to chromosome number. Our results also suggest that Xist expression may itself be regulated by a novel imprinted maternally expressed gene.
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Citations
Cites
Gene Action in the X-chromosome of the Mouse (Mus musculus L.)
LYON, M. F. (1961) · Nature · doi:10.1038/190372a0 · Cited by 3,978
Role of paternal and maternal genomes in mouse development
Barton, S. C., Surani, M. A. H., & Norris, M. L. (1984) · Nature · doi:10.1038/311374a0 · Cited by 724
Self-citation
Cited by
The functional role of long non-coding RNA in human carcinomas
Gibb, E. A., Brown, C. J., & Lam, W. L. (2011) · Molecular Cancer · doi:10.1186/1476-4598-10-38 · Cited by 1,619
Requirement for Xist in X chromosome inactivation
Penny, G. D., Kay, G. F., Sheardown, S. A., Rastan, S., & Brockdorff, N. (1996) · Nature · doi:10.1038/379131a0 · Cited by 1,205
Self-citationNonrandom X-inactivation patterns in normal females: lyonization ratios vary with age
Busque, L., Mio, R., Mattioli, J., Brais, E., Blais, N., Lalonde, Y., Maragh, M., & Gilliland, D. (1996) · Blood · doi:10.1182/blood.v88.1.59.59 · Cited by 543
X Chromosome Dosage Compensation: How Mammals Keep the Balance
Payer, B., & Lee, J. T. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.42.110807.091711 · Cited by 521
Cross, S. H., & Bird, A. P. (1995) · Current Opinion in Genetics & Development · doi:10.1016/0959-437x(95)80044-1 · Cited by 450
Metadata
- Authors
- Kay, G. F., Barton, S. C., Surani, M. A., & Rastan, S.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1994-06
- Volume
- 77
- Issue
- 5
- Pages
- 639-650
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1994670375
- Cited by
- 230
- References
- 2
- FWCI
- 11.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kay, G. F., Barton, S. C., Surani, M. A., & Rastan, S. (1994). Imprinting and X chromosome counting mechanisms determine Xist expression in early mouse development. Cell. https://doi.org/10.1016/0092-8674(94)90049-3
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