The DOI matches its Crossref record; 268 of the 268 references it cites were found in a registry or an index.
X Chromosome Dosage Compensation: How Mammals Keep the Balance
Abstract
The development of genetic sex determination and cytologically distinct sex chromosomes leads to the potential problem of gene dosage imbalances between autosomes and sex chromosomes and also between males and females. To circumvent these imbalances, mammals have developed an elaborate system of dosage compensation that includes both upregulation and repression of the X chromosome. Recent advances have provided insights into the evolutionary history of how both the imprinted and random forms of X chromosome inactivation have come about. Furthermore, our understanding of the epigenetic switch at the X-inactivation center and the molecular aspects of chromosome-wide silencing has greatly improved recently. Here, we review various facets of the ever-expanding field of mammalian dosage compensation and discuss its evolutionary, developmental, and mechanistic components.
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Metadata
- Authors
- Payer, B., & Lee, J. T.
- Venue
- Annual Review of Genetics
- Publisher
- Annual Reviews
- Published
- 2008-12-01
- Volume
- 42
- Issue
- 1
- Pages
- 733-772
- ISSN
- 0066-4197 (ISSN-L)
- 1545-2948
- OpenAlex
- W2101378716
- Cited by
- 521
- References
- 268
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Payer, B., & Lee, J. T. (2008). X Chromosome Dosage Compensation: How Mammals Keep the Balance. Annual Review of Genetics. https://doi.org/10.1146/annurev.genet.42.110807.091711
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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