The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP
Open accessAbstract
To investigate the function of the autophosphorylated form of CaMKII in synaptic plasticity, we generated transgenic mice that express a kinase that is Ca2+ independent as a result of a point mutation of Thr-286 to aspartate, which mimics autophosphorylation. Mice expressing the mutant form of the kinase show an increased level of Ca(2+)-independent CaMKII activity similar to that seen following LTP. The mice nevertheless exhibit normal LTP in response to stimulation at 100 Hz. However, at lower frequencies, in the range of 1-10 Hz, there is a systematic shift in the size and direction of the resulting synaptic change in the transgenic animals that favors LTD. The regulation of this frequency-response function by Ca(2+)-independent CaMKII activity seems to account for two previously unexplained synaptic phenomena, the relative loss of LTD in adult animals compared with juveniles and the enhanced capability for depression of facilitated synapses.
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Cites
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Cited by
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Self-citationSensitivity of CaM Kinase II to the Frequency of Ca 2+ Oscillations
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Metadata
- Authors
- Mayford, M., Wang, J., Kandel, E. R., & O'Dell, T. J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1995-06
- Volume
- 81
- Issue
- 6
- Pages
- 891-904
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2080152563
- Cited by
- 524
- References
- 14
- FWCI
- 13.85
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP. https://app.cochat.ai/papers/10.1016/0092-8674(95)90009-8
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- Mayford, M., Wang, J., Kandel, E. R., & O'Dell, T. J. (1995). CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP. Cell. https://doi.org/10.1016/0092-8674(95)90009-8
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
