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Cited by 481

The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.

Impairment of spatial but not contextual memory in CaMKII mutant mice with a selective loss of hippocampal ltp in the range of the θ frequency

Open access
Bach, Mary Elizabeth, Hawkins, Robert D, Osman, Mona, Kandel, Eric R, Mayford, Mark·1995·Cell
DOI 10.1016/0092-8674(95)90010-1
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Abstract

We assessed hippocampal-dependent memory in mice with a Ca(2+)-independent form of CaMKII generated by the introduction of an aspartate at amino acid 286. The CaMKII-Asp-286 mice show normal LTP at high frequency stimulation, but in the 5-10 Hz range, they show a shift in the frequency-response curve favoring LTD. This range of frequencies is similar to the theta rhythm, which is associated with exploration in rodents. Using the Barnes maze to assess spatial memory, we found the transgenic mice could not learn to navigate to a specific location using spatial cues. In contrast, one line of transgenic mice performed normally in contextual fear conditioning, a task that is also hippocampal dependent. This dissociation between spatial and contextual memory suggests that even though both require the hippocampus, they may be mediated by different synaptic mechanisms.

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Metadata

Authors
Bach, M. E., Hawkins, R. D., Osman, M., Kandel, E. R., & Mayford, M.
Venue
Cell
Publisher
Elsevier BV
Published
1995-06
Volume
81
Issue
6
Pages
905-915
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/0092-8674(95)90010-1
OpenAlex
W2022224180
Cited by
481
References
63
FWCI
13.07
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Impairment of spatial but not contextual memory in CaMKII mutant mice with a selective loss of hippocampal ltp in the range of the θ frequency. https://app.cochat.ai/papers/10.1016/0092-8674(95)90010-1
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Bach, M. E., Hawkins, R. D., Osman, M., Kandel, E. R., & Mayford, M. (1995). Impairment of spatial but not contextual memory in CaMKII mutant mice with a selective loss of hippocampal ltp in the range of the θ frequency. Cell. https://doi.org/10.1016/0092-8674(95)90010-1

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