The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
A genetic test of the effects of mutations in PKA on mossy fiber ltp and its relation to spatial and contextual learning
Open accessAbstract
Using a genetic approach, we assessed the effects of mutations in protein kinase A (PKA) on long-term potentiation (LTP) in the mossy fiber pathway and its relationship to spatial and contextual learning. Ablation by gene targeting of the C beta 1 or the RI beta isoform of PKA produces a selective defect in mossy fiber LTP, providing genetic evidence for the role of these isoforms in the mossy fiber pathway. Despite the elimination of mossy fiber LTP, the behavioral responses to novelty, spatial learning, and conditioning to context are unaffected. Thus, contrary to current theories about hippocampal function, mossy fiber LTP does not appear to be required for spatial or contextual learning. In the absence of mossy fiber LTP, adequate spatial and contextual information might reach the CA1 region via other pathways from the entorhinal cortex.
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“first, theplasticity inthe EC-DGandDG-CA3 synapses seems to be dispensable (Huang et al., 1995; Nosten-Bertrand et al., 1996);”
From The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. (1996) · cites this paper as Huang et al., 1995
In the citing paper
“By contrast, it has been shown that impairments of mossy fiber-CA3 LTP(Huang etal., 1995) and perforant path-dentate LTP (Nosten-Bertrand et al., 1996) are not correlated with spatial memory deficit.”
From The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. (1996) · cites this paper as Huang et al., 1995
In the citing paper
“For example, forskolin evokes LTP at the mossy fiber3 CA3 synapse, whereas the inactive forskolin homolog, 1,9-dideoxy-forskolin, does not (Weisskopf et al., 1994), and mutant mice lacking PKA C1 or Ri subunits are defective in mossy fiber LTP (Huang et al., 1995).”
From Type I Adenylyl Cyclase Mutant Mice Have Impaired Mossy Fiber Long-Term Potentiation (1998) · cites this paper as Huang et al., 1995
Citations
Cites
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Long-Term Potentiation and Memory
Lynch, M. A. (2004) · Physiological Reviews · doi:10.1152/physrev.00014.2003 · Cited by 2,074
The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory.
Tsien, J. Z., Huerta, P. T., & Tonegawa, S. (1996) · Cell · doi:10.1016/s0092-8674(00)81827-9 · Cited by 1,782
A Family of cAMP-Binding Proteins That Directly Activate Rap1
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Cognitive Neuroscience and the Study of Memory
Milner, B. A., Squire, L. R., & Kandel, E. R. (1998) · Neuron · doi:10.1016/s0896-6273(00)80987-3 · Cited by 1,335
Self-citationAbel, T., Nguyen, P. V., Barad, M., Deuel, T. A. S., Kandel, E. R., & Bourtchouladze, R. (1997) · Cell · doi:10.1016/s0092-8674(00)81904-2 · Cited by 1,217
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Metadata
- Authors
- Huang, Y.-Y., Kandel, E. R., Varshavsky, L., Brandont, E. P., Qi, M., Idzerda, R. L., Stanley McKnight, G., & Bourtchouladz, R.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of Washington (US)
- ORCID
- Kandel, Eric R.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1995-12
- Volume
- 83
- Issue
- 7
- Pages
- 1211-1222
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2094988830
- Cited by
- 267
- References
- 56
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 7 · 2014: 5 · 2013: 7 · 2012: 8
- FWCI
- 11.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (GM32675)
- Howard Hughes Medical Institute (MH50733)
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- protein kinase A, hippocampus, spatial learning, contextual learning, novelty response, gene targeting, entorhinal cortex, CA1, hippocampal function
- MeSH terms
- Animals, Conditioning, Psychological, Electrophysiology, Female, Colforsin, Hippocampus, Isoenzymes, Isoproterenol, Male, Mice, Inbred C57BL, Mutation, Spatial Behavior, Long-Term Potentiation, Cyclic AMP-Dependent Protein Kinases, Mice, Knockout, Maze Learning, Mice, Cyclic AMP-Dependent Protein Kinase RIbeta Subunit
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