Cited by 407Diabetes and associated disordersDiabetes Management and ResearchDiabetes, Cardiovascular Risks, and Lipoproteins

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Incidence of childhood-onset insulin-dependent diabetes mellitus: the EURODIAB ACE study

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Green, A., Gale, E.A.M., Patterson, C.C.·1992·The Lancet

DOI 10.1016/0140-6736(92)90938-y

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Abstract

EURODIAB ACE is a collaborative European study that was set up to assess incidence of childhood insulin-dependent diabetes mellitus (IDDM) in Europe, test the proposal of a south-north gradient, and to gather information to determine the causes and pathogenesis of the disease. Here, the basic epidemiological results are reported. Newly diagnosed cases of IDDM in children aged up to 15 years were identified prospectively in twenty-four geographically well-defined study regions in Europe and Israel (a total of 16.8 million children) during 1989 and 1990. 3060 cases were identified with estimated ascertainment rates exceeding 90% in all study regions. Age-standardised and sex-standardised incidence rates varied widely, ranging from 4.6 (northern Greece) to 42.9 (two regions in Finland) cases per 100,000 per year. Rates in southern Europe were generally higher than previously assumed, and there was an unexpectedly high incidence in Sardinia, which had the second highest rate (30.2 cases per 100,000 per year) recorded in Europe. Eastern European regions had generally low rates. The collaborative network now established provides a framework for further studies to examine the complex interaction between genetic and environmental factors in the cause and pathogenesis of IDDM.

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Authors: Green, A., Gale, E. A. M., & Patterson, C. C.
Affiliations: University of Southern Denmark (DK)
St Bartholomew's Hospital (GB)
Queen's University Belfast (GB)
Corresponding author: Green, A.
ORCID: Green, A.
Gale, E.A.M.
Patterson, C.C.
Venue: The Lancet
Publisher: Elsevier BV
Published: 1992-04
Volume: 339
Issue: 8798
Pages: 905-909
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/0140-6736(92)90938-y
OpenAlex: W2008539299
Cited by: 407
References: 23
Citations by year: 2025: 2 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 3 · 2020: 2 · 2019: 7 · 2018: 9 · 2017: 7 · 2016: 11 · 2015: 11 · 2014: 9 · 2013: 7 · 2012: 10
FWCI: 11.39
Type: journal article
Language: en
Open access: green
orbilu.uni.lu
Licence: cc-by-nc-sa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Open Repository and Bibliography (University of Luxembourg) (submittedVersion, cc-by-nc-sa)
VUBIR (Vrije Universiteit Brussel) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: type 1 diabetes, childhood-onset diabetes, incidence, age-standardized incidence rate, Sardinia, genetic and environmental risk factors, pathogenesis
MeSH terms: Adolescent, Child, Child, Preschool, Diabetes Mellitus, Type 1, Epidemiologic Methods, Europe, Female, Humans, Infant, Israel, Male, Prospective Studies

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Incidence of childhood-onset insulin-dependent diabetes mellitus: the EURODIAB ACE study

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