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Cited by 37Diabetes and associated disordersDiabetes Management and ResearchDiabetes, Cardiovascular Risks, and Lipoproteins

Incidence and seasonality of type 1 diabetes: a population-based 3-year cohort study using the National Database in Japan

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Nishioka, Yuichi, Noda, Tatsuya, Okada, Sadanori, Myojin, Tomoya, Kubo, Shinichiro, Higashino, Tsuneyuki, Ishii, Hitoshi, Imamura, Tomoaki·2020·BMJ Open Diabetes Research & Care
DOI 10.1136/bmjdrc-2020-001262PMC PMC7526280
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Abstract

Introduction: To investigate the incidence of type 1 diabetes by age group (0–19, 20–39, 40–59, ≥60 years) in Japan and whether there is seasonality in this incidence. Research design and methods: The incidence of type 1 diabetes from September 2014 to August 2017 was estimated using 2013–2018 data from the National Database of Health Insurance Claims and Specific Health Check-ups of Japan. The incidence rate was analyzed using Tango’s Index and the self-controlled case series method. Results: Overall, 10 400 of the 79 175 553 included individuals were diagnosed with type 1 diabetes. The incidence of type 1 diabetes from September 2014 to August 2017 was 4.42/100 000 person-years. The incidence rates for men aged 0–19, 20–39, 40–59, and ≥60 years were 3.94, 5.57, 5.70, and 3.48, respectively. Among women, the incidence rates for the same age ranges were 5.22, 4.83, 4.99, and 3.31, respectively. Tango’s index showed that the incidence rate of type 1 diabetes was significantly associated with seasons among those aged 0–19 years. Further, the self-controlled case series method showed a significant interaction between age and season, with the incidence of type 1 diabetes being higher in spring for patients younger than 20 years of age. Conclusions: In Japan, men aged 40–59 years and women aged 0–19 years are the groups with the highest incidence of type 1 diabetes. Further, the incidence of younger-onset diabetes in Japan was higher in spring (from March to May).

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  • In Japan, type 1 diabetes mellitus incidence was 3.48 per 100,000 person-years in men and 3.31 per 100,000 person-years in women aged ≥60 years.

    “The authors reported incidences of 3.48 and 3.31 per 100,000 person-years in men and women aged ≥60 years, respectively.”

    From The epidemiology of type 1 diabetes mellitus in older adults (2025) · cites this paper as [18]

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Sorted by citations

Authors
Nishioka, Y., Noda, T., Okada, S., Myojin, T., Kubo, S., Higashino, T., Ishii, H., & Imamura, T.
Affiliations
  • Nara Medical University (JP)
  • Mitsubishi Research Institute (Japan) (JP)
Corresponding author
Noda, Tatsuya
ORCID
Venue
BMJ Open Diabetes Research & Care
Publisher
BMJ
Published
2020-09
Volume
8
Issue
1
Pages
e001262
ISSN
2052-4897 (ISSN-L)
DOI
10.1136/bmjdrc-2020-001262
PMC
PMC7526280
OpenAlex
W3091245387
Cited by
37
References
2
Citations by year
2026: 3 · 2025: 6 · 2024: 7 · 2023: 6 · 2022: 10 · 2021: 5
FWCI
3.08
Type
journal article
Language
en
Open access
Licence
Locations
  • BMJ Open Diabetes Research & Care (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
Japan Society for the Promotion of Science (JP18H04126, JP18K17390)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
type 1 diabetes, incidence, seasonal variation, age-specific incidence, sex differences, Japan
MeSH terms
Diabetes Mellitus, Type 1, Female, Humans, Japan, Male, Middle Aged, Seasons, Cohort Studies, Incidence

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