The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Intestinal permeability and the prediction of relapse in Crohn's disease
Abstract
To see whether intestinal permeability (IP) predicted relapse in Crohn's disease, we measured IP in 72 patients with quiescent Crohn's disease using the lactulose-mannitol test. The permeability index (lactulose/mannitol) was significantly higher in patients than in controls (0.046 [SEM 0.005] vs 0.018 [SEM 0.002], respectively). Patients were followed for 1 year after the test. 26 of the 37 patients with raised permeability, but only 6 of the 35 with normal permeability relapsed within 1 year after the test (p < 0.001). The sensitivity of the permeability test as a predictor for relapse was 81%. A significant correlation was found between the value of the permeability index and the probability of relapse (p < 0.01). These results show that increases in intestinal permeability precede clinical relapses in Crohn's disease and so are an indicator of subclinical disease. The measurement of intestinal permeability may lead to a better understanding of the pathogenesis of Crohn's disease.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Other objective measures associated with disease activity for IBD such as fecal calprotectin 31 , gut permeability 32 or gut lavage fluid protein have high sensitivity for presence or absence of active disease 33 .”
From The Manitoba IBD Index: Evidence for a New and Simple Indicator of IBD Activity (2009) · cites this paper as [32]
Citations
Cites
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1992) · Springer series in statistics · doi:10.1007/978-1-4612-4380-9_25 · Cited by 45,239
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158
(1990) · Choice Reviews Online · doi:10.5860/choice.27-3338 · Cited by 35,305
Evaluation of survival data and two new rank order statistics arising in its consideration.
Mantel, N. (1966) · PubMed · Cited by 7,516
Development of a Crohn's Disease Activity Index
Best, W. R., Becktel, J. M., Singleton, J. W., & Kern, F. (1976) · Gastroenterology · doi:10.1016/s0016-5085(76)80163-1 · Cited by 3,152
Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study.
Best, W. R., Becktel, J. M., Singleton, J. W., & Kern, F. (1976) · PubMed · Cited by 3,147
Plackett, R. L., & Cox, D. R. (1971) · Journal of the Royal Statistical Society Series A (General) · doi:10.2307/2344247 · Cited by 2,274
European Cooperative Crohn's Disease Study (ECCDS): Results of drug treatment
Malchow, H. A., Ewe, K., Brandes, J. W., Goebell, H., Ehms, H., Sommer, H., & Jesdinsky, H. J. (1984) · Gastroenterology · doi:10.1016/0016-5085(84)90409-8 · Cited by 931
Evidence for continuous stimulation of interleukin-6 production in Crohn's disease
Groß, V., Andus, T., Caesar, I., Roth, M., & Schölmerich, J. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)90098-j · Cited by 293
A laboratory index for predicting relapse in asymptomatic patients with Crohn's disease
Brignola, C., Campieri, M., Bazzocchi, G., Farruggia, P., Tragnone, A., & Lanfranchi, G. A. (1986) · Gastroenterology · doi:10.1016/0016-5085(86)90206-4 · Cited by 159
Cited by
Sorted by citations
Intestinal mucosal barrier function in health and disease
Turner, J. R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2653 · Cited by 3,952
Microbial translocation is a cause of systemic immune activation in chronic HIV infection
Brenchley, J. M., Price, D. A., Schacker, T. W., Asher, T. E., Silvestri, G., Rao, S., Kazzaz, Z., Bornstein, E., Lambotte, O., Altmann, D., et al. (2006) · Nature Medicine · doi:10.1038/nm1511 · Cited by 3,559
Intestinal epithelial cells: regulators of barrier function and immune homeostasis
Peterson, L. W., & Artis, D. (2014) · Nature reviews. Immunology · doi:10.1038/nri3608 · Cited by 3,367
Inflammatory bowel disease: Etiology and pathogenesis
Fiocchi, C. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70381-6 · Cited by 2,059
Intestinal barrier function: molecular regulation and disease pathogenesis
Groschwitz, K. R., & Hogan, S. P. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.05.038 · Cited by 1,775
Metadata
- Authors
- Wyatt, J., Vogelsang, H., Hübl, W., Waldhoer, T., & Lochs, H.
- Corresponding author
- Lochs, H.
- ORCID
- Waldhoer, T.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1993-06
- Volume
- 341
- Issue
- 8858
- Pages
- 1437-1439
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2080195364
- Cited by
- 626
- References
- 16
- Citations by year
- 2026: 6 · 2025: 19 · 2024: 12 · 2023: 15 · 2022: 25 · 2021: 25 · 2020: 21 · 2019: 17 · 2018: 19 · 2017: 22 · 2016: 23 · 2015: 23 · 2014: 24 · 2013: 17 · 2012: 26
- FWCI
- 4.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- Crohn's disease, intestinal permeability, recurrence prediction, lactulose/mannitol test, permeability index, subclinical disease, pathogenesis, inflammatory bowel disease
- MeSH terms
- Adult, Crohn Disease, Female, Humans, Intestinal Mucosa, Lactulose, Male, Mannitol, Permeability, Predictive Value of Tests, Recurrence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
