Cited by 626Inflammatory Bowel DiseaseGastrointestinal motility and disordersOcular Diseases and Behçet’s Syndrome

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Intestinal permeability and the prediction of relapse in Crohn's disease

Wyatt, J., Vogelsang, H., Hübl, W., Waldhoer, T., Lochs, H.·1993·The Lancet

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Abstract

To see whether intestinal permeability (IP) predicted relapse in Crohn's disease, we measured IP in 72 patients with quiescent Crohn's disease using the lactulose-mannitol test. The permeability index (lactulose/mannitol) was significantly higher in patients than in controls (0.046 [SEM 0.005] vs 0.018 [SEM 0.002], respectively). Patients were followed for 1 year after the test. 26 of the 37 patients with raised permeability, but only 6 of the 35 with normal permeability relapsed within 1 year after the test (p < 0.001). The sensitivity of the permeability test as a predictor for relapse was 81%. A significant correlation was found between the value of the permeability index and the probability of relapse (p < 0.01). These results show that increases in intestinal permeability precede clinical relapses in Crohn's disease and so are an indicator of subclinical disease. The measurement of intestinal permeability may lead to a better understanding of the pathogenesis of Crohn's disease.

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Authors: Wyatt, J., Vogelsang, H., Hübl, W., Waldhoer, T., & Lochs, H.
Corresponding author: Lochs, H.
ORCID: Waldhoer, T.
Venue: The Lancet
Publisher: Elsevier BV
Published: 1993-06
Volume: 341
Issue: 8858
Pages: 1437-1439
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/0140-6736(93)90882-h
OpenAlex: W2080195364
Cited by: 626
References: 16
Citations by year: 2026: 6 · 2025: 19 · 2024: 12 · 2023: 15 · 2022: 25 · 2021: 25 · 2020: 21 · 2019: 17 · 2018: 19 · 2017: 22 · 2016: 23 · 2015: 23 · 2014: 24 · 2013: 17 · 2012: 26
FWCI: 4.21
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords: Crohn's disease, intestinal permeability, recurrence prediction, lactulose/mannitol test, permeability index, subclinical disease, pathogenesis, inflammatory bowel disease
MeSH terms: Adult, Crohn Disease, Female, Humans, Intestinal Mucosa, Lactulose, Male, Mannitol, Permeability, Predictive Value of Tests, Recurrence

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Intestinal permeability and the prediction of relapse in Crohn's disease

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