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Cited by 380Stress Responses and CortisolMemory and Neural MechanismsNeuroendocrine regulation and behavior

The DOI matches its Crossref record; 157 of the 157 references it cites were found in a registry or an index.

Allostasis, amygdala, and anticipatory angst

Schulkin, Jay, McEwen, Bruce S., Gold, Philip W.·1994·Neuroscience & Biobehavioral Reviews
DOI 10.1016/0149-7634(94)90051-5
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Abstract

Regions of the amygdala are involved in anticipation of negative events. Chronic anticipation of negative events leads to what we call allostatic load, or arousal pathology. Two hormones appear to be involved in arousal pathology; corticotropin-releasing hormone in the brain and glucocorticoids. We suggest that increases in corticotropin-releasing hormone, by stress or glucocorticoids, in the amygdala may have functional consequences for allostatic load. Whereas, corticotropin-releasing hormone in the parvocellular region of the paraventricular nucleus of the hypothalamus is decreased by glucocorticoids thereby under negative feedback and homeostatic control, the central nucleus of the amygdala is to some extent under positive feedback and is increased by glucocorticoids, and perhaps under allostatic control. The human and animal literature suggest that a variety of psychopathologies (e.g., melancholia) may be tied to neurohormonal signals activating regions of the amygdala.

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Citations

Cites

Show all 153 references

Research works printed but not linked: 17

  1. Alheid, 1992, Amygdala pathways in sodium appetite in the rat: Anatomical considerations, Neurosci. Abstr.
  2. Angulo, 1991, Adrenal glucocorticoid regulates the angiotensinogen gene expression in the rat brain, Neurosci. Abstr.
  3. Brady, 1992, Intrahippocampal colchicine alters hypothalamic corticotropin-releasing hormone and hippocampal receptor mRNA in rat brain, Brain Res., 55, 121
  4. Chrousos, 1992, The concepts of stress and stress system disorders, JAMA, 267, 1244, 10.1001/jama.267.9.1244 · DOI · Paper page
  5. Colson, 1992, Upregulation of vasopressin receptors by glucocorticoids, Am. J. Physiol., 26, E1054
  6. Duncan, 1983, The amygdala is a site of action of imipramine in a screen for antidepressant agents, Neurosci. Abstr., 9, 427
  7. Grahn, 1992, The effect of inescapable shock on shuttle-box escape performance, conditioned fear, and anxiety in rats with lesions of the dorsal raphe nucleus or central nucleus of the amygdala, Society Neurosci. Abstracts, 18, 534
  8. Johnston, 1923, Further contributions to the study of the evolution of the forebrain, J. Comp. Neurol., 35, 481, 10.1002/cne.900350502 · DOI · Paper page
  9. Koob, 1981, Corticotropin releasing factor produces behavioral activation and improves learning in rats, Neurosci. Abstract, 145
  10. LeDoux, 1987, Emotion, vol. 5, 419
  11. Makino, 1993, Corticosterone effects on crh mrna in parvovellular pvn and the central nucleus of the amygdala, Neurosci. Abstr.
  12. Phillips, 1992, Overlapping and divergent projections of CA1 and the ventral subiculum to the amygdala, Society Neurosci. Abstr.
  13. Pich, 1992, Stress-induced release of corticotropin releasing factor in the amygdala measured by in vivo microdialysis, Society Neurosci. Abstr., 18, 535
  14. Rivier, 1981, In vivo corticotropin releasing factor-induced secretion of adrenocorticotropin, β-endorphin and corticosterone, Endocrinology, 110, 272, 10.1210/endo-110-1-272 · DOI
  15. Rosen, J. B.; Pishevar, S.; Weiss, S. B. Smith, M. A.; Kling, M.; Gold, P; Schulkin, J.; Glucocorticoid potentiation of CRH-induced seizures. Neurosci. Lett. (in press).
  16. Turner, 1980, Organiztion of the amygdalopetal projections from modality-specific cortical association areas in the monkey, J. Comp. Neurol., 191, 543, 10.1002/cne.901910402 · DOI
  17. Watts, 1993, Neurotensin/neuromedian N mRNA levels are selectively regulated by corticosterone in fore-brain cell groups, Neurosci. Abstr.

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Metadata

Authors
Schulkin, J., McEwen, B. S., & Gold, P. W.
Affiliations
National Institute of Mental Health (US)
Corresponding author
Schulkin, Jay
ORCID
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
1994-09
Volume
18
Issue
3
Pages
385-396
ISSN
0149-7634 (ISSN-L)
DOI
10.1016/0149-7634(94)90051-5
OpenAlex
W1974467694
Cited by
380
References
153
Citations by year
2026: 1 · 2025: 5 · 2024: 30 · 2023: 6 · 2022: 8 · 2021: 4 · 2020: 6 · 2019: 6 · 2018: 13 · 2017: 9 · 2016: 14 · 2015: 7 · 2014: 10 · 2013: 6 · 2012: 14
FWCI
2.84
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords
allostasis, allostatic load, amygdala, anticipatory anxiety, corticotropin-releasing factor, glucocorticoids, hypothalamic paraventricular nucleus, central amygdala, negative feedback, positive feedback, stress, melancholia, psychopathology, neuroendocrine regulation
MeSH terms
Amygdala, Animals, Anxiety, Homeostasis, Humans

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