CoChat
Sign Up
Cited by 167Regulation of Appetite and ObesityEating Disorders and BehaviorsNutrition, Health and Food Behavior

The DOI matches its Crossref record; 20 of the 21 references it cites were found in a registry or an index.

Human eating: Evidence for a physiological basis using a modified paradigm

Campfield, L.Arthur, Smith, Francoise J., Rosenbaum, Michael, Hirsch, Jules·1996·Neuroscience & Biobehavioral Reviews
DOI 10.1016/0149-7634(95)00043-e
Open this paper in CoChat — free account

Abstract

The aim of these studies was to determine if meal requests and changes in hunger ratings in humans were related to spontaneous changes in blood glucose concentration. In our first study, 18 healthy subjects were acutely isolated from food ant time cues. Blood glucose was continuously monitored online and visual analog ratings of hunger were obtained following an overnight fast. Spoken meal requests, if they occurred, were also recorded. In 83% of the subjects, both the perception and behavioral expression of hunger, as assessed by changes in hunger ratings and meal requests, were preceded by, and correlated with, brief, transient declines in blood glucose (nadir: -10% at 27 min). The pattern, magnitude and time course of these declines was similar to those observed in rats. This significant association, between increased expression of hunger and declines in blood glucose, is being tested in a second, ongoing study using acute insulin infusions to mimic spontaneous transient declines in blood glucose. Each subject was studied twice: either insulin or saline was infused while hunger ratings were obtained. Preliminary results in five subjects indicate that hunger ratings increased after insulin-induced transient declines in blood glucose. No change in hunger ratings occurred when blood glucose concentration was stable. These results suggest that this temporal pattern of blood glucose reflects an antecedent physiological event or provides a signal related to the expression of hunger in humans. Further understanding of human eating may result from investigation of the complex interaction of physiological and other factors in an experimental setting that allows the expression the behavior under study.

Overview

Integrity signals

Registry

Crossref · 10.1016/0149-7634(95)00043-e

Cites

20 of 20 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 21 references

1 of the 21 references couldn’t be matched to a known paper.

Research works printed but not linked: 5

  1. Campfield, 1986, Blood glucose and meal initiation: A role for insulin?, Soc. Neurosci. Abstr., 12, 209
  2. Campfield, 1991, Meal initiation in obese Zucker rats is predicted by blood glucose dynamics, Int. J. Obesity, 15, 54
  3. Grinker, 1971, The effects of intravenous administration of glucose, saline, and mannitol on meal regulation in normal-weight human subjects, Behav. Biol., 6, 203
  4. Smith, 1991, Glucose dependent meal initiation: transient declines in blood glucose precede meal onset in experimentally induced diabetes in rats, Diabetes, 40, 29a
  5. Van Itallie, 1990, The glucostatic theory 1953–1988: Roots and branches, Int. J. Obesity, 14, 1

Cited by

Sorted by citations

See all 167

Related

Metadata

Authors
Campfield, L. A., Smith, F. J., Rosenbaum, M., & Hirsch, J.
Affiliations
Rockefeller University (US)
Corresponding author
Campfield, L.Arthur
ORCID
Rosenbaum, Michael
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
1996-01
Volume
20
Issue
1
Pages
133-137
ISSN
0149-7634 (ISSN-L)
DOI
10.1016/0149-7634(95)00043-e
OpenAlex
W2027646272
Cited by
167
References
21
Citations by year
2026: 3 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 5 · 2015: 5 · 2014: 6 · 2013: 11 · 2012: 1
FWCI
1.82
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5k08dk001983-02, 2m01rr000102-41, 5r01dk030583-18)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK-30583, DK01983)
  • National Center for Research Resources (RR00102)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
  • Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
Keywords
hunger, blood glucose, food intake regulation, insulin infusion, food deprivation
MeSH terms
Adult, Blood Glucose, Eating, Feeding Behavior, Female, Humans, Hunger, Male, Time Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review