The DOI matches its Crossref record; 23 of the 25 references it cites were found in a registry or an index.
Stimulation of in vivo antibody production and concanavalin-A-induced mouse spleen cell mitogenesis by prolactin
Abstract
Regulation of the immune system by neuroendocrine hormones is receiving increased attention. Prolactin, a hormone normally associated with lactation, has been shown recently to reconstitute immunosuppressed hypophysectomized rats. The present studies demonstrate that prolactin administration to normal mice results in a biphasic stimulation of antibody production to sheep red blood cells. While 100 and 200 micrograms bovine prolactin/animal stimulated antibody production, 400 micrograms had no effect. Potentiation of lectin-induced T-cell mitogenesis by prolactin was also biphasic. As the concentration of prolactin increased the incorporation of [3H]thymidine into the cells first increased and then decreased. Decreasing serum prolactin levels with the dopaminergic agonist bromocriptine resulted in a reduction of antibody titers to sheep erythrocytes and a modulation of thymic weight. These data show that prolactin can stimulate the immune system in a biphasic manner and that a reduction in the basal levels of this hormone results in an attenuated immune response.
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“changes in self-reported sleep duration were also evident in the incubation phase of the illness, before symptom development (for review, see Ref. 517).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [517]
In the citing paper
“experimentally induced influenza A and B and rhinovirus-induced common colds in healthy participants led to an increase of self-reported sleep duration in the symptomatic phase of the illness (517).”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [517]
Citations
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Self-citation
Cited by
Sorted by citations
Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783
The Sleep-Immune Crosstalk in Health and Disease
Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479
Besedovsky, L., Lange, T., & Born, J. (2012) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-011-1044-0 · Cited by 1,153
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Metadata
- Authors
- Spangelo, B. L., Hall, N. R. S., Ross, P. C., & Goldstein, A. L.
- Affiliations
- George Washington University (US)
- Corresponding author
- Hall, Nicholas R.S.
- ORCID
- Goldstein, Allan L.
- Venue
- Immunopharmacology
- Publisher
- Elsevier BV
- Published
- 1987-09
- Volume
- 14
- Issue
- 1
- Pages
- 11-20
- ISSN
- 0162-3109 (ISSN-L)
- OpenAlex
- W2054696207
- Cited by
- 113
- References
- 25
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 2 · 2019: 2 · 2018: 1 · 2016: 1 · 2013: 1 · 2012: 1
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Immunopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH 00648)
- National Cancer Institute (CA-24974)
- National Institute of Neurological Disorders and Stroke (NS 21210)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- prolactin, antibody production, concanavalin A, T cell mitogenesis, sheep red blood cells, bromocriptine, dopamine agonists, thymidine incorporation, thymus weight, neuroendocrine-immune regulation, immunosuppression, hypophysectomy
- MeSH terms
- Animals, Antibody Formation, Bromocriptine, Concanavalin A, Dose-Response Relationship, Drug, Erythrocytes, Lymphocyte Activation, Male, Mice, Inbred C57BL, Prolactin, Receptors, Prolactin, Spleen, Mice
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