The DOI matches its Crossref record; 207 of the 209 references it cites were found in a registry or an index.
Lipid composition and metabolism in normal and diseased epidermis
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The main constituents of lipid lamellae are ceramides, cholesterol, and FFAs, of which ceramides account for 50% by weight (4).”
From Comparative profiling and comprehensive quantification of stratum corneum ceramides in humans and mice by LC/MS/MS (2020) · cites this paper as [4]
Citations
Cites
A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES
Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189
A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION
Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-099 · Cited by 54,751
A NEW DEFICIENCY DISEASE PRODUCED BY THE RIGID EXCLUSION OF FAT FROM THE DIET
Burr, G. O., & Burr, M. M. (1929) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)78281-5 · Cited by 1,170
Form and function of phospholipids
ANSELL, G. B., Hawthorne, J. N., & DAWSON, R. M. C. (1973) · Medical Entomology and Zoology · Cited by 1,069
ON THE NATURE AND RÔLE OF THE FATTY ACIDS ESSENTIAL IN NUTRITION
Burr, G. O., & Burr, M. M. (1930) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)78929-5 · Cited by 981
ACRODERMATITIS ENTEROPATHICA: A LETHAL INHERITED HUMAN ZINC-DEFICIENCY DISORDER
Moynahan, E. J. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91772-3 · Cited by 626
The Biological Synthesis of Cholesterol
Bloch, K. (1965) · Science · doi:10.1126/science.150.3692.19 · Cited by 562
Growth, Nutrition, and Metabolism of Cells in Culture
(1977) · Elsevier eBooks · doi:10.1016/b978-0-12-598303-7.x5001-2 · Cited by 465
Effect of ethanol on liver 8-aminolaevulinate synthetase in rats.
SHANLEY, B. C., Zail, S. S., & Joubert, S. M. (1968) · The Lancet · Cited by 428
ACUTE ANTERIOR UVEITIS AND HL-A 27
Brewerton, D. A., Caffrey, M., Nicholls, A., Walters, D., & James, D. C. O. (1974) · The Lancet · doi:10.1016/s0140-6736(74)92431-3 · Cited by 366
Research works printed but not linked: 6
- Aso, 1971, Lipogenesis in epidermis. Malonyl CoA pathway and elongation, Jap. J. Derm., 81, 299
- De Groot, 1979, X-Linked ichthyosis and placental steroid-sulphatase deficiency, J. Invest. Dermatol., 72, 271
- Hansen, 1944, Clinical and blood lipid studies in a child with chylous ascites, Am. J. Dis. Child., 68, 351
- Loomans, 1971, Chemical compositions of cell envelopes from human callus, stratum corneum, and psoriatic scale, J. Invest. Dermatol., 56, 410
- Rothblat, 1972, Vol. 1, 297
- Ziboh, 1978, Activation of phospholipase A2 and increased release of prostaglandin precursor from skin by ultraviolet irradiation, J. Invest. Dermatol., 70, 211
Cited by
Sorted by citations
Items 201–267 of 267
Disturbances of Epidermal Lipid Metabolism and Barrier Function in Atopic Eczema
Melnik, B. C. (1991) · Springer eBooks · doi:10.1007/978-3-662-02671-7_31 · Cited by 11
Rawlings, A. V., Lane, M. E., & Voegeli, R. (2024) · International Journal of Cosmetic Science · doi:10.1111/ics.12955 · Cited by 11
Transcriptional profiling of epidermal barrier formation in vitro
Bachelor, M. A., Binder, R. L., Cambron, R. T., Kaczvinsky, J. R., Spruell, R. D., Wehmeyer, K. R., Reilman, R., Adams, R. L., Tiesman, J. P., Wang, Y., et al. (2013) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2013.11.004 · Cited by 10
The effects of equine skin preparation on transdermal drug penetration in vitro.
Mills, P. C., & Cross, S. E. (2006) · Europe PMC (PubMed Central) · Cited by 10
Localization of β-glucosidase activity within keratinizing epithelia
Chang, F., Wertz, P. W., & Squier, C. A. (1993) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(93)90204-h · Cited by 10
Synthesis of Unique Ceramides and Cerebrosides Occurring in Human Epidermis
Müller, S., & Schmidt, R. R. (1993) · Helvetica Chimica Acta · doi:10.1002/hlca.19930760141 · Cited by 10
Mandal, T. K., & Downing, D. T. (1993) · Acta Dermato Venereologica · doi:10.2340/00015555731217 · Cited by 10
Ando, H. Y., Schultz, T. W., Schnaare, R. L., & Sugita, E. T. (1984) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600730409 · Cited by 10
Structure and Function of Skin
Monteiro-Riviere, N. A. (2005) · CRC Press eBooks · doi:10.1201/9780203020821.ch1 · Cited by 9
Mahi, Y. E., Varin, A., Vetter, M., Zuffo, L. D., Mazzeo, L., de Barros, J.-P. P., Aubin, F., Saas, P., & Sérézal, I. G. (2023) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2023.04.021 · Cited by 9
Pierre, M. B. R., Lopez, R. F. V., & Bentley, M. V. L. B. (2009) · Brazilian Journal of Pharmaceutical Sciences · doi:10.1590/s1984-82502009000100013 · Cited by 9
Demonstration of free fatty acids in the integument of semi-aquatic and aquatic mammals
Meyer, W., Schmidt, J., Busche, R., Jacob, R., & Naim, H. Y. (2011) · Acta Histochemica · doi:10.1016/j.acthis.2011.03.011 · Cited by 9
Sonnenberger, S., Eichner, A., Hauß, T., Schroeter, A., Neubert, R. H. H., & Dobner, B. (2017) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2017.02.001 · Cited by 9
Human Stratum Corneum Lipid-Based Liposomes (hSCLLs)
Lasch, J., Schmitt, U., Papahadjopoulos‐Sternberg, B., & Schubert, R. (1994) · Journal of Liposome Research · doi:10.3109/08982109409037031 · Cited by 9
Iino, Y., Naganuma, T., & Arita, M. (2023) · Journal of Lipid Research · doi:10.1016/j.jlr.2023.100329 · Cited by 8
Damage/Recovery by Additive on Lipid Membrane as a Mimicry of Human Stratum Corneum
Zhu, Y., Imae, T., Saiwaki, T., & Oka, T. (2009) · Langmuir · doi:10.1021/la903602v · Cited by 8
Sonnenberger, S., Eichner, A., Schmitt, T., Hauß, T., Lange, S., Langner, A., Neubert, R. H. H., & Dobner, B. (2017) · Journal of Labelled Compounds and Radiopharmaceuticals · doi:10.1002/jlcr.3504 · Cited by 8
Tanikawa, S., & Miyajima, K. (1995) · Chemistry and Physics of Lipids · doi:10.1016/0009-3084(95)02460-z · Cited by 8
Gaur, P. K., Purohit, S., & Mishra, S. (2013) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2013.828579 · Cited by 7
A structural model for the human skin barrier
Forslind, B., Norlen, L. P. O., & Engblom, J. (2008) · Steinkopff eBooks · doi:10.1007/bfb0117959 · Cited by 7
Studies on the Biosynthesis of the Antibiotic Moenomycin A
Schuricht, U., Endler, K., Hennig, L., Findeisen, M., & Welzel, P. (2000) · Journal für praktische Chemie · doi:10.1002/1521-3897(200010)342:8 · Cited by 16
Recent advancement on nanotechnology and natural compounds for skin UV protection: a review
Saadh, M. J., Jain, V., Rekha, M. M., Pathak, P. K., Ahmed, H. M., Naidu, K. S., Juneja, B., Sead, F. F., & Dehghanipour, M. (2025) · International Journal of Environmental Science and Technology · doi:10.1007/s13762-025-06589-w · Cited by 6
Meneses, P. I., Crane, J. M., & Ennis, W. J. (1998) · Skin Research and Technology · doi:10.1111/j.1600-0846.1998.tb00089.x · Cited by 6
Essential Fatty Acids in Clinical Dermatology
Wright, S. (1990) · Journal of Nutritional Medicine · doi:10.3109/13590849009097887 · Cited by 6
Estrone-and dehydroepiandrosterone-sulfatase activities in human female epidermis
Prost, O., Nicollier, M., Laurent, R., & Adessi, G. (1985) · Archives of Dermatological Research · doi:10.1007/bf00404316 · Cited by 6
Anatomical Factors Affecting Barrier Function
Monteiro-Riviere, N. A. (2004) · Informa Healthcare eBooks · doi:10.1201/9780203426272.ch4 · Cited by 6
GURR, M. I., Harwood, J. L., & Frayn, K. N. (2002) · doi:10.1002/9780470774366.ch6 · Cited by 6
How many skin barriers haveth we: Percutaneous egression of ions?
Chiang, C., & Maïbach, H. I. (2021) · Skin Research and Technology · doi:10.1111/srt.13119 · Cited by 5
Zou, J.-X., Chua, W., Ser, Z., Wang, S. M., Chiang, G. S. H., Sanmugam, K., Tan, B. Y., Sobota, R. M., & Li, H. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202307553 · Cited by 5
Nanocarriers for Photodynamic Therapy Intended to Cutaneous Tumors
Pierre, M. B. R. (2021) · Current Drug Targets · doi:10.2174/1389450122999210101230743 · Cited by 5
Linoleic Acid and Epidermal Water Barrier
Hansen, H. S. (1989) · Springer eBooks · doi:10.1007/978-1-4757-2043-3_30 · Cited by 5
Lipid Content and Electrical Impedance
Nicander, I., Norl�n, L., Forslind, B., & Ollmar, S. (1998) · KARGER eBooks · doi:10.1159/000060559 · Cited by 5
Forslind, B., Wei, X., & Roomans, G. M. (1983) · Springer eBooks · doi:10.1007/978-3-642-68682-5_28 · Cited by 5
The Structure of the Human Skin Barrier
Forslind, B. (2000) · Springer eBooks · doi:10.1007/978-3-662-07677-4_6 · Cited by 4
Visual observation of selective elution of components from skin-mimetic lipid membrane
Wang, X., Ujihara, M., Imae, T., Saiwaki, T., Ishikubo, A., & Okamoto, T. (2010) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2010.07.007 · Cited by 4
Epidermal Lipids and the Intercellular Pathway
Wertz, P. W. (2015) · Springer eBooks · doi:10.1007/978-3-662-45013-0_2 · Cited by 4
In vivo study of biomechanical properties in psoriasis vulgaris: Effectiveness of sulfur spa therapy
Mazzulla, S., Nicoletta, V., Perrotta, I. D., Stefano, S. D., & Sesti, S. (2013) · Open Journal of Molecular and Integrative Physiology · doi:10.4236/ojmip.2013.31003 · Cited by 3
Greiner, J. V., Glonek, T., Townsend, D. J., & Hearn, S. L. (1998) · Archives of Dermatological Research · doi:10.1007/s004030050308 · Cited by 3
Wertz, P. W. (2014) · Springer eBooks · doi:10.1007/978-3-319-09943-9_5 · Cited by 3
Hydrocarbons of Scalp Hair Lipids from Teenage Males
Gershbein, L. L., Baburao, K., & Sheladia, K. (1984) · Fette Seifen Anstrichmittel · doi:10.1002/lipi.19840860908 · Cited by 3
Zhou, H., Zhang, C., Tang, B., Zhang, H., Zheng, J., Wang, K., He, D., & Hao, Y. (2024) · Current Zoology · doi:10.1093/cz/zoae049 · Cited by 2
Brezesinski, G., Opálka, L., Shen, C. C., Groetzsch, C., Schneck, E., & Eichner, A. (2025) · Langmuir · doi:10.1021/acs.langmuir.5c01340 · Cited by 2
Development and characterization of stable nanovesicular carrier for drug delivery
Gaur, P. K., Purohit, S., Kumar, Y., Mishra, S., & Bhandari, A. (2013) · Artificial Cells Nanomedicine and Biotechnology · doi:10.3109/21691401.2013.818009 · Cited by 2
Kage, M., Itaya, Y., Horikoshi, J., & Tokudome, Y. (2021) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2021.101135 · Cited by 3
Plewig, G., & Kligman, A. M. (2000) · Springer eBooks · doi:10.1007/978-3-642-59715-2_6 · Cited by 2
Amphiphilic Association Structures of the Stratum Corneum
Friberg, S. E., Ma, Z., & Rhein, L. D. (1991) · Springer eBooks · doi:10.1007/978-1-4615-3836-3_12 · Cited by 2
Analysis of the non-ionic detergent-soluble lipids of human stratum corneum*
Dykes, P. J., Williams, D. L., & Marks, R. (1984) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1984.tb04633.x · Cited by 2
Nuutila, K. (2013) · Työväentutkimus Vuosikirja · Cited by 2
Ziboh, V. A. (1999) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8761-8_4 · Cited by 2
Acid ceramidase ASAH1 is a key regulator of epidermal ceramide levels and composition
Nobumoto, W., Naganuma, T., Nozaka, N., Ohno, Y., Nojiri, K., & Kihara, A. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.111178 · Cited by 1
Fan, Y., Wei, C., Su, N., Ma, Y., Liu, W., Sun, P., & Shan, S. (2025) · International Journal of Cosmetic Science · doi:10.1111/ics.13065 · Cited by 2
Models, Methods, and Measurements in Transdermal Drug Delivery
Cropek, D. M., & Karande, P. (2017) · Springer eBooks · doi:10.1007/978-3-662-53270-6_9 · Cited by 1
Epidermal Lipids in Atopic Eczema
Proksch, E., Fölster‐Holst, R., & Jensen, J. (2006) · Springer eBooks · doi:10.1007/3-540-29856-8_37 · Cited by 1
Körting, H. C. (1993) · Fortschritte der praktischen Dermatologie und Venerologie · doi:10.1007/978-3-642-78163-6_58 · Cited by 1
Chen, H., Luo, W., Guo, Z., Li, Z., Feng, J., Cao, S., Wang, Q., Gu, Z., Krutmann, J., Wang, J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.04.674196 · Cited by 1
Die Bedeutung hauteigener Lipide für die Rolle der Haut als Abwehrorgan
Jüstel, C., Traupe, B., Bünger, J., Drexler, D., Mathes, S., Meier, C., & Wolf, F. (2000) · Springer eBooks · doi:10.1007/978-3-642-57191-6_2
Cheng, J. (2005) · Summit (Simon Fraser University)
Investigation of Skin Moisture Maintenance Using Horse Oil
Kikyo, G., Fujishige, S., & Ichimaru, Y. (2004) · The Nishinihon Journal of Dermatology · doi:10.2336/nishinihonhifu.66.621
Percutaneous Absorption Of Analgerics In The Presence Of Permeation Enhancers
Shah, S. N. H. (2009)
Ziboh, V. A. (1997) · Advances in experimental medicine and biology · doi:10.1007/978-1-4899-1810-9_59
Integrated Transdermal Drug Delivery and Pharmacokinetics in Development
Berner, B., & Kochak, G. M. (2021) · doi:10.1002/9781119772767.ch7
GURR, M. I., & Harwood, J. L. (1991) · Springer eBooks · doi:10.1007/978-1-4615-3862-2_8
Zou, J.-X., Chua, W., Ser, Z., Wang, S. M., Chiang, G. S. H., Sanmugam, K., Tan, B. Y., Sobota, R. M., & Li, H. (2023) · Angewandte Chemie · doi:10.1002/ange.202307553
Wang, X., Ma, R., Shi, R., Qin, H., Chen, W. J., Yu, Z., Ding, Y., Peng, C., & Shi, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26642719
Metadata
- Authors
- Yardley, H. J., & Summerly, R.
- Affiliations
- Keele University (GB)
- Royal Stoke University Hospital (GB)
- Venue
- Pharmacology & Therapeutics
- Publisher
- Elsevier BV
- Published
- 1981-01
- Volume
- 13
- Issue
- 2
- Pages
- 357-383
- ISSN
- 0163-7258 (ISSN-L)
- OpenAlex
- W2005090658
- Cited by
- 267
- References
- 209
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 8 · 2020: 2 · 2019: 1 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 11 · 2012: 4
- FWCI
- 4.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- epidermis, skin lipids, lipid metabolism, lipid composition, skin diseases, stratum corneum
- MeSH terms
- Fatty Acids, Fatty Acids, Essential, Humans, Hydrocarbons, Ichthyosis, Keratins, Lipids, Phospholipids, Psoriasis, Skin, Skin Diseases, Skin Physiological Phenomena, Sphingolipids, Sterols, Subcellular Fractions, Waxes, Lipid Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review