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Lipid composition and metabolism in normal and diseased epidermis
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“The main constituents of lipid lamellae are ceramides, cholesterol, and FFAs, of which ceramides account for 50% by weight (4).”
From Comparative profiling and comprehensive quantification of stratum corneum ceramides in humans and mice by LC/MS/MS (2020) · cites this paper as [4]
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Identification of vitamin D3 in human skin.
Rauschkolb, E. W., Davis, H. W., Fenimore, D. C., Black, H. S., & Fabre, L. F. (1969) · PubMed · Cited by 28
Freinkel, R. K., & Aso, K. (1969) · Journal of Investigative Dermatology · doi:10.1038/jid.1969.22 · Cited by 27
Studies of the Lipids of Dog Skin
Wheatley, V. R., Chow, D. C., & Keenan, F. D. (1961) · Journal of Investigative Dermatology · doi:10.1038/jid.1961.40 · Cited by 26
Rauschkolb, E. W., Davis, H. W., Fenimore, D. C., Black, H. S., & Fabre, L. F. (1969) · Journal of Investigative Dermatology · doi:10.1038/jid.1969.149 · Cited by 26
The effects of essential fatty acid deficiency on the fine structure of mouse skin
Menton, D. N. (1970) · Journal of Morphology · doi:10.1002/jmor.1051320206 · Cited by 25
Thin-layer chromatography of phospholipid components of normal and psoriatic epidermis
TSAMBAOS, D., KALOFOUTIS, A., STRATIGOS, J., MIRAS, C., & CAPETANAKIS, J. (1977) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1977.tb15058.x · Cited by 25
Chylous Ascites and Lymphedema
Warwick, W. J. (1959) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1959.02070020319005 · Cited by 25
Yardley, H. J., & GOLDSTEIN, D. J. (1976) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1976.tb07034.x · Cited by 25
Self-citationGinsburg, R. (1976) · Archives of Dermatology · doi:10.1001/archderm.112.5.653 · Cited by 25
Cutaneous lipogenesis: precursors utilized by guinea pig skin for lipid synthesis
Wheatley, V. R., Hodgins, L. T., Coon, W. M., Kumarasiri, M., Berenzweig, H., & Feinstein, J. M. (1971) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39516-x · Cited by 24
Patterson, J. F., & Griesemer, R. D. (1959) · Journal of Investigative Dermatology · doi:10.1038/jid.1959.151 · Cited by 24
Flesch, P., & Esoda, E. C. J. (1962) · Journal of Investigative Dermatology · doi:10.1038/jid.1962.132 · Cited by 24
Brooks, S. C., Godefroi, V. C., & Simpson, W. L. (1963) · Journal of Investigative Dermatology · doi:10.1038/jid.1963.154 · Cited by 23
Acetate metabolism: Effects of tracer concentration
Emerson, R. J., & Bruggen, J. T. V. (1958) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(58)90093-6 · Cited by 23
CHOLESTREOL SYNTHESIS IN ICHTHYOSIS VULGARIS
and, R. S., & Yardley, H. J. (1967) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1967.tb11515.x · Cited by 22
Self-citationGaylor, J. L. (1963) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)81115-2 · Cited by 22
STUDIES ON THE REGULATION OF CHOLESTEROL SYNTHESIS IN THE SKIN AND PREPUTIAL GLAND OF THE RAT
Wilson, J. D. (1963) · Elsevier eBooks · doi:10.1016/b978-0-08-009945-3.50014-5 · Cited by 22
Esterification of Sterols During Differentiation and Cornification of Developing Rat Epidermis
Freinkel, R. K., & Fiedler‐Weiss, V. C. (1974) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12701701 · Cited by 21
GRAY, G. M., King, I. A., & Yardley, H. J. (1980) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1980.tb01665.x · Cited by 21
Self-citationLipogenesis in Epidermal Differentiation of Embryonic Chicken Skin
Freinkel, R. K. (1972) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12627389 · Cited by 21
Lipogenesis in rat skin: A possible regulatory role of glycerol 3-phosphate
Ziboh, V. A., & Hsia, S. L. (1969) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(69)90115-5 · Cited by 21
Comparison of barrier function and lipids in psoriasis and essential fatty acid-deficient rats
Hartop, P. J., Allenby, C. F., & Prottey, C. (1978) · Clinical and Experimental Dermatology · doi:10.1111/j.1365-2230.1978.tb01497.x · Cited by 20
Mitochondria and Nuclei of Pig and Human Epidermis: Isolation and Lipid Composition
Gray, G. M., & Yardley, H. J. (1975) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12512400 · Cited by 20
Self-citationLipid Synthesis from Acetate-1-14C by Suction Blister Epidermis and Other Skin Components
Hsia, S. L., Fulton, J. E., Fulghum, D. D., & Buch, M. M. (1970) · Experimental Biology and Medicine · doi:10.3181/00379727-135-35037 · Cited by 20
Keratinization in Historical Perspective
Rothman, S. S. (1964) · Elsevier eBooks · doi:10.1016/b978-1-4832-3293-5.50007-3 · Cited by 20
Incorporation of Acetate-1-C14 into Fatty Acids of Isolated Epidermal Cells
Wilkinson, D. I. (1970) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12257158 · Cited by 20
Cooper, M. F., Thody, A. J., & Shuster, S. (1974) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(74)90169-6 · Cited by 19
Ultrastructural Features of Ichthyotic Skin in Refsum’s Syndrome
Blanchet‐Bardon, C., Anton‐Lamprecht, I., Puissant, A., & Schnyder, U. W. (1978) · Springer eBooks · doi:10.1007/978-94-010-9851-9_9 · Cited by 19
Biosynthesis of skin sterols. II. Reduction of Δ24-unsaturated sterols of rat skin
Gaylor, J. L. (1963) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(63)90541-1 · Cited by 19
The phospholipid pattern in the involved and the uninvolved psoriatic epidermis
Tsambaos, D., & Mahrle, G. (1979) · Archives of Dermatological Research · doi:10.1007/bf00694626 · Cited by 19
Lipogenesis in Human Skin. III. Variation with Body Site
Griesemer, R. D., & Thomas, R. W. (1963) · Journal of Investigative Dermatology · doi:10.1038/jid.1963.101 · Cited by 19
Inhibition of prostaglandin biosynthesis by c−5, c−8, c−11-eicosatrienoic acid
van Evert, W. C., Nugteren, D. H., & van Dorp, D. A. (1978) · Prostaglandins · doi:10.1016/0090-6980(78)90165-x · Cited by 19
ESSENTIAL FATTY ACIDS AND THE SKIN
Sinclair, H. M. (1958) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a069693 · Cited by 18
Sex-linked ichthyosis and placental sulphatase C deficiency
de Groot, W. P., Jöbsis, A. C., Ilsen, A., Koppe, J. G., & de Bruijn, H. W. A. (1980) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1980.tb15840.x · Cited by 17
Phospholipase A Activity in the Epidermis
Long, V., & Yardley, H. J. (1972) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12538971 · Cited by 17
Self-citationYASUMURA, M., Okano, T., MIZUNO, K., & Kobayashi, T. (1977) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.23.513 · Cited by 17
Lipogenesis from amino acids in perfused isolated dog skin
Wheatley, V. R., Lipkin, G., & Woo, T. H. (1967) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38919-7 · Cited by 17
Some in vitro effects of hypoglycin on skin.
Yardley, H. J., & Godfrey, G. (1967) · PubMed · Cited by 16
Self-citationSequence of Histologic Changes in Skin of Dogs in Relation to Dietary Fat
Hansen, A. E., Sinclair, J. G., & Wiese, H. F. (1954) · Journal of Nutrition · doi:10.1093/jn/52.4.541 · Cited by 16
Mitotic Activity in the Skin of Mice Deficient in Essential Fatty Acids
NASR, A. N., & Shostak, S. (1965) · Nature · doi:10.1038/2071395a0 · Cited by 15
Gaylor, J. L. (1963) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(63)90495-8 · Cited by 15
Prottey, C., & Hartop, P. J. (1973) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12676222 · Cited by 15
Possible defects in triacylglycerol and phosphatidyl- choline metabolism in psoriatic epidermis
Summerly, R., ILDERTON, E., & GRAY, G. M. (1978) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1978.tb01997.x · Cited by 15
Self-citationEnzymes of Sterol Biosynthesis
Gaylor, J. L. (1974) · Elsevier eBooks · doi:10.1016/b978-0-8391-1043-9.50007-9 · Cited by 14
Esterification of cholesterol by epidermis
Freinkel, R. K., & Aso, K. (1971) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(71)90198-6 · Cited by 14
FLUX OF FATTY ACIDS DURING EPIDERMAL DIFFERENTIATION
Freinkel, R. K., & Traczyk, T. N. (1977) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12510328 · Cited by 14
In Vivo Chemotaxis Induced by Polyunsaturated Fatty Acids
Penneys, N. S., Simon, P., Ziboh, V. A., & Schlossberg, J. (1977) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12510727 · Cited by 14
PROTTEY, G., Hartop, P. J., & Ferguson, T. F. M. (1972) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1972.tb07450.x · Cited by 14
Phospholipase A and Lysophospholipase activity of the epidermis
Long, V. (1975) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1975.tb03138.x · Cited by 14
Cl, M., Jonniaux, G., Voet, W., & Bergen, C. J. V. D. (1974) · PubMed · Cited by 14
Carruthers, C. (1962) · PubMed · Cited by 13
Polyunsaturated fatty acids of skin; Identification and14C‐Acetate incorporation
Wilkinson, D. I. (1972) · Lipids · doi:10.1007/bf02533021 · Cited by 13
Preparation and properties of a cell-free system from rat skin that catalyzes sterol biosynthesis
Gaylor, J. L., Delwiche, C. V., Brady, D. R., & Green, A. J. (1966) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39260-9 · Cited by 13
Compositional differences of lipid in transformed hamster fibroblasts
Fu-Chang, C., Eng, L. F., & Griffin, A. (1972) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(72)90032-x · Cited by 12
Lipid Metabolism in Human Skin I. Lipogenesis from Acetate-1-14C*
Hsia, S. L., Sofer, G., & Lane, B. (1966) · Journal of Investigative Dermatology · doi:10.1038/jid.1966.166 · Cited by 11
Incorporation of i-14C-acetate into the lipids of isolated epidermal cells
Long, V. (1976) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1976.tb04380.x · Cited by 10
Proliferative epidermis of essential fatty acid deficient mice has reduced cyclic AMP content
Lowe, N. J., DUELL, E., & Voorhees, J. J. (1979) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1979.tb15289.x · Cited by 9
MEASUREMENT OF LIPID SYNTHESIS IN MOUSE AURICULAR SKIN CULTURED IN VITRO
Prottey, C., & Ferguson, T. F. M. (1972) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1972.tb01596.x · Cited by 9
Studies of the Lipids of Dog Skin III
Lipkin, G., Wheatley, V. R., & March, C. H. (1965) · Journal of Investigative Dermatology · doi:10.1038/jid.1965.142 · Cited by 9
Lipogenesis in Human Skin. IV. In Vitro Rate Studies*
Griesemer, R. D., & Thomas, R. W. (1966) · Journal of Investigative Dermatology · doi:10.1038/jid.1966.165 · Cited by 8
Lipogenesis During Cornification of Chicken Skin in Organ Culture
Freinkel, R. K. (1972) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12627395 · Cited by 8
The Role of Fatty Acid Oxidation in The Epidermis
Anastasia, J. V., & Conley, J. P. (1977) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12510725 · Cited by 8
Essential fatty acid supplementation inhibits the effect of dietary zinc deficiency.
Cunnane, S. C., Ge, S., & Horrobin, D. F. (1980) · PubMed · Cited by 8
Chemical Anomalies in Pathological Horny Layers
Flesch, P., & Esoda, E. C. J. (1964) · Elsevier eBooks · doi:10.1016/b978-1-4832-3293-5.50034-6 · Cited by 8
Demonstration of �-lipoproteins in the psoriatic skin by immunofluorescent technique
Ishikawa, H., & Sato, H. (1974) · Archives of Dermatological Research · doi:10.1007/bf00604821 · Cited by 7
Sterol synthesis: studies of the metabolism of 14 alpha-methyl-5 alpha-cholest-7-en-3 beta-ol.
Chan, J. T., Spike, T. E., Trowbridge, S. T., & Schroepfer, G. J. (1979) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40003-3 · Cited by 7
THE EFFECTS OF SOME COMPOUNDS ON THE ENDOGENOUS RESPIRATION OF SKIN
Long, V., & Yardley, H. J. (1971) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1971.tb07204.x · Cited by 6
Self-citationThe origin of lanosta-7,24-dienol in rat skin
Hornby, G. M., & Boyd, G. S. (1971) · Biochemical Journal · doi:10.1042/bj1240831 · Cited by 6
Some Factors Affecting C14-Acetate Incorporation into Polyunsaturated Fatty Acids of Skin
Wilkinson, D. I. (1973) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12724457 · Cited by 5
Syndrome of ichthyosis, hepatosplenomegaly and cerebellar degeneration—steroid sulphatase activity
Dykes, P. J., Marks, R., & Harper, P. S. (1980) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1980.tb08154.x · Cited by 5
Profile of epidermal metabolic activity in autosomal dominant ichthyosis and small bowel disorders
Dykes, P. J., Marks, R., & Smith, P. D. (1978) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1978.tb03578.x · Cited by 5
Studies of the Lipids of Dog Skin. IV
Lipkin, G., Wheatley, V. R., Woo, T. H., & March, C. H. (1968) · Journal of Investigative Dermatology · doi:10.1038/jid.1968.74 · Cited by 5
Epidermal Lipogenesis in Ichthyosis
Cooper, M. F., McGibbon, D., & Shuster, S. (1978) · Springer eBooks · doi:10.1007/978-94-010-9851-9_3 · Cited by 4
Epidermal lipid biosynthesis in acne
Shuster, S., Cooper, M. F., McGibbon, D., & Wilson, P. (1980) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1980.tb06580.x · Cited by 4
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Metadata
- Authors
- Yardley, H. J., & Summerly, R.
- Affiliations
- Keele University (GB)
- Royal Stoke University Hospital (GB)
- Venue
- Pharmacology & Therapeutics
- Publisher
- Elsevier BV
- Published
- 1981-01
- Volume
- 13
- Issue
- 2
- Pages
- 357-383
- ISSN
- 0163-7258 (ISSN-L)
- OpenAlex
- W2005090658
- Cited by
- 267
- References
- 209
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 8 · 2020: 2 · 2019: 1 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 11 · 2012: 4
- FWCI
- 4.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- epidermis, skin lipids, lipid metabolism, lipid composition, skin diseases, stratum corneum
- MeSH terms
- Fatty Acids, Fatty Acids, Essential, Humans, Hydrocarbons, Ichthyosis, Keratins, Lipids, Phospholipids, Psoriasis, Skin, Skin Diseases, Skin Physiological Phenomena, Sphingolipids, Sterols, Subcellular Fractions, Waxes, Lipid Metabolism
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