The DOI matches its Crossref record; 124 of the 129 references it cites were found in a registry or an index.
The estrogenic and antiestrogenic activities of androgens in female target tissues.
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“4-Dione also led to significant growth inhibition in ZR-75-1 cells, although the active concentrations (IC 50 , 15 nm) are in the upper range of the plasma concentrations (1-10 nm) found in women (215-218).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [215]
In the citing paper
“In ZR-75-1 cells, concentrations of DHT in the incubation medium similar to the plasma levels found in normal women (215-217) and breast cancer patients (Ref.218; 0.3-0.7 nm) are potent inhibitors of the mitogenic effect of E 2 and even inhibit growth in the absence of estrogens (208).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [215]
In the citing paper
“The data summarized above clearly support the hypothesis that at least part of the antagonism observed between the action of androgens and estrogens in breast cancer cells (208,211,215,240) may be explained by the heterologous downregulation of the ER by an AR-mediated mechanism.”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [215]
In the citing paper
“The concentration of DHT needed to exert a half-maximal suppression of ER binding activity (0.07-0.1 nm) is lower than the concentration known to induce binding and nuclear retention of the ER (215, 234).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [215]
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Self-citation
Metadata
- Authors
- Rochefort, H., & Garcia, M.
- Affiliations
- Inserm (FR)
- ORCID
- Garcia, Marcel
- Venue
- Pharmacology & Therapeutics
- Publisher
- Elsevier BV
- Published
- 1983-01
- Volume
- 23
- Issue
- 2
- Pages
- 193-216
- ISSN
- 0163-7258 (ISSN-L)
- OpenAlex
- W2023676722
- Cited by
- 107
- References
- 129
- Citations by year
- 2026: 2 · 2025: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 4 · 2013: 1 · 2012: 1
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Oncology › Male Breast Health Studies
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Keywords
- androgens, estrogenic activity, antiestrogenic activity, gynecomastia, male breast enlargement, breast histopathology
- MeSH terms
- Androgens, Animals, Breast Neoplasms, Cell Nucleus, Estrogen Antagonists, Estrogens, Female, Humans, Neoplasms, Receptors, Estrogen, Receptors, Progesterone, Rats
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