Human breast cancer: androgen action mediated by estrogen receptor.
Abstract
Growth of the human breast cancer cell line MCF-7 is enhanced by androgens, but only at pharmacological concentrations. Although physiological concentrations of androgens translocate the androgen receptor into the nucleus, no mitogenic effects are observed. By contrast, pharmacological androgens translocate not only the androgen receptor but also the estrogen receptor, and at these high doses significantly increase both DNA and estrogen-dependent protein synthesis. We therefore propose that androgens stimulate MCF-7 cell growth not through the androgen receptor but rather through the estrogen receptor.
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The primary site of action of DHT on [3H]E2-specific binding was clearly consistent with a specific interaction with the AR, rather than a direct activation and processing of the ER by DHT.
“Thus, the primary site of action of DHT on [ 3 H]E 2 -specific binding was clearly consistent with a specific interaction with the AR, rather than a direct activation and processing of the ER by DHT (234 -239).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [237]
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- Authors
- Zava, D. T., & McGuire, W. L.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- Venue
- Science
- Published
- 1978-02-17
- Volume
- 199
- Issue
- 4330
- Pages
- 787-788
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2075739846
- Cited by
- 82
- References
- 7
- Citations by year
- 2018: 2 · 2016: 1 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 7.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Keywords
- breast cancer, androgen action, estrogen receptor, androgen receptor, MCF-7 cells, cell growth, mitogen response, receptor translocation, DNA synthesis, protein synthesis
- MeSH terms
- Androgens, Breast Neoplasms, Cell Line, Cell Nucleus, Cytoplasm, Humans, Receptors, Androgen, Receptors, Estrogen, Receptors, Glucocorticoid, Receptors, Progesterone, Dihydrotestosterone, Stimulation, Chemical, Translocation, Genetic
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