Cited by 134Circadian rhythm and melatoninBipolar Disorder and TreatmentTreatment of Major Depression

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Rhythms and the pharmacology of lithium

Klemfuss, Harry·1992·Pharmacology & Therapeutics

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Abstract

Lithium is the treatment of choice for bipolar affective disorder (manic-depression) and is useful in other recurrent affective and nonaffective illnesses. This review discusses lithium's actions on period, phase, amplitude and coupling of biological rhythms that may relate to its therapeutic effectiveness. Alternatively, lithium might interact with environmental light to influence circadian rhythms by an action on the retina. The mechanisms responsible for lithium's chronopharmacological actions are not known, but cellular cations, phosphoinositide or adenylate cyclase second messenger systems, hormones and neurotransmitters may all be involved.

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Authors: Klemfuss, H.
Affiliations: Veterans Health Administration (US)
Corresponding author: Klemfuss, Harry
Venue: Pharmacology & Therapeutics
Publisher: Elsevier BV
Published: 1992-01
Volume: 56
Issue: 1
Pages: 53-78
ISSN: 0163-7258 (ISSN-L)
DOI: 10.1016/0163-7258(92)90037-z
OpenAlex: W1987982071
Cited by: 134
References: 229
Citations by year: 2024: 2 · 2023: 1 · 2022: 5 · 2021: 2 · 2020: 3 · 2019: 2 · 2017: 5 · 2016: 9 · 2015: 6 · 2014: 6 · 2013: 7 · 2012: 4
FWCI: 0.74
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacology & Therapeutics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: lithium, circadian rhythm, chronopharmacology, bipolar disorder, biological rhythms, light exposure, retina, second messenger signaling, phosphoinositides, adenylate cyclase, neurotransmitters, hormones, mood disorders
MeSH terms: Animals, Chronobiology Phenomena, Circadian Rhythm, Humans, Lithium

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Rhythms and the pharmacology of lithium

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