Lithium delays circadian phase of temperature and REM sleep in a bipolar depressive: a case report
Abstract
The effects of lithium on the circadian rhythms of body temperature and rapid eye movement (REM) sleep were examined in a patient with bipolar depression. The acrophase of body temperature showed a phase delay of 74 min after 1 week of lithium treatment. REM latency increased significantly with lithium, and the onset of subsequent REM periods was also delayed. The proportion of the night spent in REM sleep decreased significantly. There was no effect of lithium on the patient's mood. The data are consistent with the hypothesized phase-delaying properties of lithium but do not support the causal link between circadian phase and affective state.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The opposing therapeutic actions of SSRIs and mood stabilizers in bipolar patients could be linked to their opposing actions on rhythms, since SSRIs cause a phase advance in rhythms while lithium can cause a phase delay.
“This could be linked to their opposing actions on rhythms since SSRIs cause a phase advance in rhythms while lithium can cause a phase delay (Campbell et al., 1989; Sprouse et al., 2006).”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Campbell et al., 1989
Cites
Spitzer, R. L. (1978) · Archives of General Psychiatry · doi:10.1001/archpsyc.1978.01770300115013 · Cited by 6,946 · see citing works
Methods for cosinor-rhythmometry.
Nelson, W. E., Tong, Y. L., Lee, J. K., & Franz Halberg, A. (1979) · PubMed · Cited by 1,701 · see citing works
Winfree, A. T. (1983) · Mathematical Biosciences · doi:10.1016/0025-5564(83)90095-0 · Cited by 541 · see citing works
Rapid Cycling in Manic-Depressives Induced by Tricyclic Antidepressants
Wehr, T. A. (1979) · Archives of General Psychiatry · doi:10.1001/archpsyc.1979.01780050065007 · Cited by 408 · see citing works
(1978) · PubMed · Cited by 355 · see citing works
Circadian rhythms in psychiatry
Halaris, A. E. (1984) · Psychiatry Research · doi:10.1016/0165-1781(84)90085-4 · Cited by 319 · see citing works
Sleep Disorders: Basic and Clinical Research
Chase, M. H., & Weitzman, E. D. (1983) · Medical Entomology and Zoology · Cited by 165 · see citing works
Lithium slows rat circadian activity rhythms
Kripke, D. F., & Wyborney, V. G. (1980) · Life Sciences · doi:10.1016/0024-3205(80)90091-0 · Cited by 131 · see citing works
Self-citationA Slowing Down of Circadian Rhythms by Lithium Ions
Engelmann, W. (1973) · Zeitschrift für Naturforschung C · doi:10.1515/znc-1973-11-1214 · Cited by 100 · see citing works
Typical and Atypical Antidepressants—Clinical Practice
Gualtieri, C. T., & Golden, R. N. (1983) · Therapeutic Drug Monitoring · doi:10.1097/00007691-198309000-00028 · Cited by 98 · see citing works
Effect of Lithium on Circadian Neurotransmitter Receptor Rhythms
Kafka, M. S., Wirz‐Justice, A., Naber, D., Marangos, P. J., O’Donohue, T. L., & Wehr, T. A. (2008) · Neuropsychobiology · doi:10.1159/000117876 · Cited by 93 · see citing works
Fk, G., Wirz‐Justice, A., & Ta, W. (1982) · PubMed · Cited by 83 · see citing works
Lithium Delays Biochemical Circadian Rhythms in Rats
McEachron, D. L., Kripke, D. F., Hawkins, R., et al. (2008) · Neuropsychobiology · doi:10.1159/000117873 · Cited by 69 · see citing works
Self-citationJohnsson, A., Engelmann, W., Pflug, B., & Klemke, W. (1983) · PubMed · Cited by 64 · see citing works
The effect of lithium carbonate on the circadian rhythm of sleep in normal human subjects.
Kripke, D. F., Judd, L. L., Hubbard, B. A., Janowsky, D. S., & Huey, L. Y. (1979) · PubMed · Cited by 63 · see citing works
Self-citationFurther Evidence for Period Lengthening Effect of Li+ on Circadian Rhythms
Hofmann, K., Günderoth-Palmowski, M., Wiedenmann, G., & Engelmann, W. (1978) · Zeitschrift für Naturforschung C · doi:10.1515/znc-1978-3-411 · Cited by 58 · see citing works
Lithium Carbonate and Sleep in Affective Disorders
Kupfer, D. J. (1974) · Archives of General Psychiatry · doi:10.1001/archpsyc.1974.01760070061009 · Cited by 57 · see citing works
Mellerup, E. T., Lauritsen, B. J., Dam, H., & Rafaelsen, O. J. (1976) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1976.tb00084.x · Cited by 56 · see citing works
Schulz, H., & Lund, R. (1985) · Psychiatry Research · doi:10.1016/0165-1781(85)90029-0 · Cited by 55 · see citing works
Lithium Carbonate and Sleep in Affective Illness
Kupfer, D. J. (1970) · Archives of General Psychiatry · doi:10.1001/archpsyc.1970.01750010037008 · Cited by 53 · see citing works
Chronobiology and Psychiatric Disorders
Papolos, D. F. (1989) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-198908000-00013 · Cited by 42 · see citing works
On the explanation of short REM latencies in depression
van den Hoofdakker, R. H., & Beersma, D. G. M. (1985) · Psychiatry Research · doi:10.1016/0165-1781(85)90009-5 · Cited by 33 · see citing works
Lithium influence on the circadian rhythms of normal adults
Sasaki, M., Suzuki, M., Onda, M., Itoh, H., Kitahara, T., Takahashi, T., Kasahara, H., & MORI, A. (1982) · Advances in the biosciences · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Circadian genes, rhythms and the biology of mood disorders
McClung, C. A. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.02.003 · Cited by 666 · see citing works
Mansour, H. A., Wood, J., Logue, T., Chowdari, K. V., Dayal, M., Kupfer, D. J., Monk, T. H., Devlin, B., & Nimgaonkar, V. L. (2006) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2005.00147.x · Cited by 293 · see citing works
Circadian Phase Variation in Bipolar I Disorder
Mansour, H. A., Wood, J., Chowdari, K. V., Dayal, M., Thase, M. E., Kupfer, D. J., Monk, T. H., Devlin, B., & Nimgaonkar, V. L. (2005) · Chronobiology International · doi:10.1081/cbi-200062413 · Cited by 204 · see citing works
Bunney, B. G., & Bunney, W. E. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.07.020 · Cited by 181 · see citing works
Mansour, H. A., Talkowski, M. E., Wood, J., Chowdari, K. V., McClain, L., Prasad, K., Montrose, D., Fagiolini, A., Friedman, E. S., Allen, M. H., et al. (2009) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00756.x · Cited by 161 · see citing works
Rhythms and the pharmacology of lithium
Klemfuss, H. (1992) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(92)90037-z · Cited by 134 · see citing works
Benedetti, F., Barbini, B., Campori, E., Fulgosi, M. C., Pontiggia, A., & Colombo, C. (2001) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(01)00034-6 · Cited by 110 · see citing works
Role for the<i>Clock</i>Gene in Bipolar Disorder
McClung, C. A. (2007) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2007.72.031 · Cited by 57 · see citing works
Lee, H.-J., Son, G.-H., & Geum, D. (2013) · Psychiatry Investigation · doi:10.4306/pi.2013.10.3.225 · Cited by 48 · see citing works
- Authors
- Campbell, S. S., Gillin, J. C., Kripke, D. F., Janowsky, D. S., & Risch, S. C.
- Affiliations
- University of California San Diego (US)
- Emory University (US)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Campbell, Scott S.
- ORCID
- Kripke, Daniel F.
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 1989-01
- Volume
- 27
- Issue
- 1
- Pages
- 23-29
- ISSN
- 0165-1781 (ISSN-L)
- OpenAlex
- W2095247433
- Cited by
- 59
- References
- 23
- Citations by year
- 2026: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 2 · 2014: 2 · 2013: 3 · 2012: 3
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG05131)
- National Institute of Mental Health (MH-38738, MH30914)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- lithium, circadian rhythm, body temperature, REM sleep, bipolar depression, acrophase, REM latency, sleep onset, mood
- MeSH terms
- Bipolar Disorder, Body Temperature Regulation, Circadian Rhythm, Desipramine, Drug Therapy, Combination, Electroencephalography, Humans, Lithium, Male, Middle Aged, Psychiatric Status Rating Scales, Sleep, REM, Lithium Carbonate
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
