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Rhythms and the pharmacology of lithium
Abstract
Lithium is the treatment of choice for bipolar affective disorder (manic-depression) and is useful in other recurrent affective and nonaffective illnesses. This review discusses lithium's actions on period, phase, amplitude and coupling of biological rhythms that may relate to its therapeutic effectiveness. Alternatively, lithium might interact with environmental light to influence circadian rhythms by an action on the retina. The mechanisms responsible for lithium's chronopharmacological actions are not known, but cellular cations, phosphoinositide or adenylate cyclase second messenger systems, hormones and neurotransmitters may all be involved.
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“Interestingly, both of these drugs have been repeatedly shown to alter the circadian period, leading to a long period in Drosophila, non-human primates, rodents and humans (Johnsson et al., 1983; Welsh and Moore-Ede, 1990; Klemfuss, 1992; Hafen and Wollnik, 1994; Dokucu et al., 2005).”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Klemfuss, 1992
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Metadata
- Authors
- Klemfuss, H.
- Affiliations
- Veterans Health Administration (US)
- Corresponding author
- Klemfuss, Harry
- Venue
- Pharmacology & Therapeutics
- Publisher
- Elsevier BV
- Published
- 1992-01
- Volume
- 56
- Issue
- 1
- Pages
- 53-78
- ISSN
- 0163-7258 (ISSN-L)
- OpenAlex
- W1987982071
- Cited by
- 134
- References
- 229
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 5 · 2021: 2 · 2020: 3 · 2019: 2 · 2017: 5 · 2016: 9 · 2015: 6 · 2014: 6 · 2013: 7 · 2012: 4
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- lithium, circadian rhythm, chronopharmacology, bipolar disorder, biological rhythms, light exposure, retina, second messenger signaling, phosphoinositides, adenylate cyclase, neurotransmitters, hormones, mood disorders
- MeSH terms
- Animals, Chronobiology Phenomena, Circadian Rhythm, Humans, Lithium
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