The DOI matches its Crossref record; 204 of the 204 references it cites were found in a registry or an index.
The role of dopamine in locomotor activity and learning
Open accessAbstract
The discovery that the brain contains neurons utilizing dopamine (DA) as their transmitter has led to studies of the behavioral function of these neurons. Changes in overall level of activity of DA neurons appear to produce parallel changes in locomotor activity. Additionally, DA neurons seem to mediate in part the effects of biologically significant (reinforcing) stimuli on learning. One way in which reinforcing stimuli produce learning is to increase the incentive motivational (response-eliciting) properties of neutral stimuli associated with them; also, reinforcing stimuli maintain the incentive motivational properties of previously conditioned incentive stimuli. Normal DA functioning appears to be required for the establishment and maintenance of incentive learning in naive animals. Previous incentive learning in trained animals can influence behavior for a time even when the function of DA neurons is disrupted; however, with continued testing in the absence of normal DA functioning, previously established conditioned incentive stimuli cease to influence behavior. From these observations and recent physiological, anatomical and biochemical studies of DA systems it is suggested that the biological substrate of DA-mediated incentive learning is a heterosynaptic facilitation of muscarinic cholinergic synapses. This model has important clinical implications since it has been suggested that DA hyperfunctioning underlies the development of schizophrenia.
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“These data strongly suggest that dopaminergic activity at the time of reward consumption is involved in incentive learning (for more evidence see Beninger, 1983); a”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Beninger, 1983
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Cited by
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A neural substrate of prediction and reward
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Metadata
- Authors
- Beninger, R. J.
- Affiliations
- Queen's University (CA)
- Corresponding author
- Beninger, Richard J.
- Venue
- Brain Research Reviews
- Publisher
- Elsevier BV
- Published
- 1983-10
- Volume
- 6
- Issue
- 2
- Pages
- 173-196
- ISSN
- 0165-0173 (ISSN-L)
- OpenAlex
- W2157844171
- Cited by
- 848
- References
- 204
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 11 · 2023: 16 · 2022: 20 · 2021: 11 · 2020: 19 · 2019: 25 · 2018: 25 · 2017: 22 · 2016: 18 · 2015: 16 · 2014: 18 · 2013: 14 · 2012: 17
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Brain Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- QSpace (Queen's University Library) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- dopamine, locomotor activity, incentive learning, incentive motivation, heterosynaptic facilitation, schizophrenia, dopaminergic neurons
- MeSH terms
- Animals, Association Learning, Dopamine, Learning, Locomotion, Motivation
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